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Molecular Epidemiology of Breast Cancer

Popular Abstract in Swedish Bröstcancer är den vanligaste cancerformen i världen bland kvinnor och bara i Sverige insjuknar varje år runt 7000 personer. Vi vet att omkring 10-15% av fallen troligen beror på ärftliga faktorer och det har under senare tid gjorts stora insatser för att klargöra exakt vilka arvsanlag som har betydelse för utveckling av sjukdomen. Under början av 90-talet identifieradeHereditary breast cancer constitutes a considerable fraction of the total number of breast cancer cases occurring each year. Up until recently very few breast cancer predisposing genes were known, but many new common polymorphisms contributing to increased cancer susceptibility are continuously being identified. This thesis has focused on familial breast cancer and identifying as well as investi

Tillämpning av klämkraftsmätning på kritiska förband inom produktion

Title: Elongation controlled tightening Authors: Rickard Holm and Thomas Johansson Supervisors: Magnus Danielson, Head of DEMD, Scania CV AB Tor Ronnholm – Quality Technician, DEMD, Scania CV AB Unto Ojaniemi – Quality Engineer, DEMD, Scania CV AB Problem Discussion: Within Scania’s engine assembling the engines are assembled, tested and painted. Based on the customers increased demands on higher

Analysis of tool wear in micromilling Ti6Al4V and its impact on generated surface integrity

Tool wear is one of the dominant factors that impacts the surface integrity of machined materials. Understanding the impact of tool wear on surface integrity is crucial in micromilling, due to the size of the features being machined and the cutting tools. Therefore, this work aims to analyse the impact of tool wear on surface integrity during the micromilling of Ti6Al4V. In this context, microslot

Influence of the design of Ti (C, N)-based cermets with alternative binders on their performance and wear in milling

Ti (C, N) based cermet materials are predominantly used in continuous finishing applications of metal cutting due to their high hardness, excellent resistance to oxidation and high chemical stability. However, their application in interrupted cutting like milling are limited due to their brittle-like failure due to low fracture toughness. In this work, alternative binder systems such as Co-Ni and

Schenker's Box Handling Processes for Dell Computers at a Cross-Docking Centre in Copenhagen.

The 17th September 2001 the distributor Schenker started to cooperate with the computer systems manufacturer Dell to deliver Dell's products to the Nordic market. In the beginning of a new cooperation new processes are formed and they are often developed to solve the local, immediate problems without considering the overall picture. In the distribution network from Dell's plants in Ire

Pregnancy outcome in women with gestational diabetes – A longitudinal study of changes in demography and treatment modalities

Introduction: Gestational diabetes is on the rise and demographics are changing in many countries due to increased migration. Simultaneously, the treatment of gestational diabetes in our clinic has shifted towards metformin with substantially less insulin treatment. The aim was to study the impact of these changes on metabolic control and pregnancy outcome by comparing women diagnosed with gestati

Analysis and monitoring the initial tool damage and coating failure when hard milling Vanadis 4E with TiAlN coated PcBN

Polycrystalline cubic boron nitride (PcBN) is renowned for its exceptional hardness and thermal stability, making it ideal for extreme machining conditions. Coatings on PcBN tools further enhance performance by extending tool life and improving cutting efficiency. While uncoated PcBN tools already excel in harsh environments, coatings primarily boost durability. Although extensively studied in tur

Antimicrobial resistance in urinary pathogens among Swedish nursing home residents remains low: a cross-sectional study comparing antimicrobial resistance from 2003 to 2012

Background: There are several risk factors for the colonisation, infection and spreading of antibiotic resistant bacteria among elderly residents of nursing homes. An updated estimate of the native prevalence of antimicrobial resistance in uropathogens among Swedish nursing home residents is needed. Methods: Urine specimens were collected for culture and antimicrobial susceptibility testing agains

Aging of human muscle: structure, function and adaptability

With increasing age, human skeletal muscles gradually decrease in volume, mainly due to a reduced number of motor units and muscle fibers, and a reduced size of type 2 fibers. As a result, progressive weakening and impaired mobility occur. High-resistance strength training is beneficial, even in the very old, and could possibly reverse some of the detrimental effects of age-related weakness. The i

A new equation to estimate temperature-corrected PaCO2 from PET CO2 during exercise in normoxia and hypoxia.

End-tidal PCO2 (PET CO2 ) has been used to estimate arterial pressure CO2 (Pa CO2 ). However, the influence of blood temperature on the Pa CO2 has not been taken into account. Moreover, there is no equation validated to predict Pa CO2 during exercise in severe acute hypoxia. To develop a new equation to predict temperature-corrected Pa CO2 values during exercise in normoxia and severe acute hypoxi

Sports and leisure-time physical activity in pregnancy and birth weight: a population-based study.

We examined the association between sports and other leisure-time physical activities during pregnancy and birth weight of babies born after 37 completed weeks of gestation. All Danish-speaking pregnant women attending routine antenatal care at the Department of Obstetrics, Aarhus University Hospital, Denmark, from August 1989 to September 1991 were invited to participate in the study. A total of

Reduced iNOS expression in adenoids from children with otitis media with effusion.

Granath A, Norrby-Teglund A, Uddman R, Cardell L-O. Reduced iNOS expression in adenoids from children with otitis media with effusion. Pediatr Allergy Immunol 2010: 21: 1151-1156. © 2010 John Wiley & Sons A/S Nitric oxide (NO) is a key mediator in the local immune response of human airways. Inducible NO-synthases (iNOS), and endothelial NO-synthases (eNOS) are two enzymes known to regulate its

Glaciodynamics, Deglacial Landforms and Isostatic Uplift during the last Deglaciation of Norrbotten, Sweden

The aim of this thesis was to reconstruct the glaciodynamics, deglacial landforms, isostatic uplift and to date the deglaciation. Glaciodynamics and deglacial landforms were focused on to provide a process and depositional model for De Geer moraine and Niemisel moraine and to reveal their internal and spatial relationship, based on detailed sedimentological and structural investigations. The isost

Doing business for a “higher loyalty”? : How Swedish transnational corporations neutralise allegations of crime

In recent years, two Swedish companies have been a focus of substantial media attention: TeliaSonera and Lundin Petroleum. The defensive strategies employed by these two businesses to deal with allegations of crime will be analysed on the basis of Stanley Cohen’s theoretical work on processes of denial and neutralisation techniques. This paper will focus on a particular form of denial, namely the In recent years, two Swedish companies have been a focus of substantial media attention: TeliaSonera and Lundin Petroleum. The defensive strategies employed by these two businesses to deal with allegations of crime will be analysed on the basis of Stanley Cohen’s theoretical work on processes of denial and neutralisation techniques. This paper will focus on a particular form of denial, namely the

Medeltidshuset vid Stora Torg i Halmstad

Up until the mid 1960s you could still find significant remains of a medieval brick house in Halmstad. Since the building was rediscovered in the 1920s, numerous speculations about the house and its owners have been presented. It has been linked to the Kalente guild as well as to the guild of St. Gertrud. These hypotheses rest, however, on very flimsy basis. Thus, this article examines a whole newUp until the mid 1960s you could still findsignificant remains of a medieval brick housein Halmstad. Since the building was rediscoveredin the 1920s, numerous speculationsabout the house and its owners have beenpresented. It has been linked to the Kalenteguild as well as to the guild of St. Gertrud.These hypotheses rest, however, on veryflimsy basis. Thus, this article examines awhole new hypothes

No time to talk! Teachers' perception of workplace communication

Teachers’ perception of organizational communication was assessed with a tailored questionnaire sampling 401 primary and lower secondary school teachers from two municipalities in Sweden (response rate 61 %). Overall, the teachers were satisfied with the workplace communication climate, the communication structure, and collegial communication, while time for communication, was reported deficient.

User acceptance of a personalised home lighting system based on wearable technology

Light/dark cycles play an essential role in people's performance, mood and daily rhythm. This study aimed to evaluate an early prototype of a personalised home lighting system including body-worn loggers. A convenience sample (N = 28) wore the devices for 23 h in the field and were given a demonstration of the lighting system components. Participants reported on questionnaires their acceptance of

Bioactive adrenomedullin in sepsis patients in the emergency department is associated with mortality, organ failure and admission to intensive care

BackgroundAdrenomedullin is a vasoactive hormone with potentially prognostic and therapeutic value, which mainly has been investigated in intensive care unit (ICU) settings. The triaging in the emergency department (ED) of patients to the right level of care is crucial for patient outcome.ObjectivesThe primary aim of this study was to investigate the association of bioactive adrenomedullin (bio-AD

Solvent Paths for Square-Planar Substitutions : Part 2. Reactions between Aqua Chloro-Platinates(II) and Ethene

The kinetics for the reactions between the complexes PtCln(H2O)4-n 2−n, n = 0,1,2,3,4, (including cis- and trans-isomers for n = 2) and ethene have been studied. In the case of trans-PtCl2(H2O)2, product analysis shows that both the chloride ligand and the aqua ligand are substituted by ethene in two parallel paths, differing in rate by a factor of 1.5 only. The experiments show that ethene, and p