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Importance: Quality of life is not a standard primary outcome in ablation trials, even though symptoms drive the indication.Objective: To assess quality of life with catheter ablation vs antiarrhythmic medication at 12 months in patients with atrial fibrillation.Design, Setting, and Participants: Randomized clinical trial at 4 university hospitals in Sweden and 1 in Finland of 155 patients aged 30

Objective. To analyse the worldwide occurrence of sicca/Sjögren's (SS) syndrome associated with the use of immune checkpoint inhibitors (ICI) in patients with cancer. Methods. The ImmunoCancer International Registry (ICIR) is a Big Data- Sharing multidisciplinary network composed by 40 specialists in Rheumatology, Internal Medicine, Immunology and Oncology from 18 countries focused on the clinical

The production of Z0 bosons at large rapidities in Pb–Pb collisions at sNN=5.02TeV is reported. Z0 candidates are reconstructed in the dimuon decay channel (Z0→μ+μ−), based on muons selected with pseudo-rapidity −4.0<η<−2.5 and pT>20GeV/c. The invariant yield and the nuclear modification factor, RAA, are presented as a function of rapidity and collision centrality. The value of RAA for the 0–20% c

Background: Blood-based biomarkers for Alzheimer's disease (AD) might facilitate identification of participants for clinical trials targeting amyloid beta (Abeta) accumulation, and aid in AD diagnostics. We examined the potential of plasma markers Abeta(1-42/1-40), glial fibrillary acidic protein (GFAP) and neurofilament light (NfL) to identify cerebral amyloidosis and/or disease severity. Methods

Background and aims: Children with extremely low-birth weight (ELBW) have a high risk for cognitive, motor, and attention impairments and learning disabilities. Longitudinal follow-up studies to a later age are needed in order to increase understanding of the changes in neurodevelopmental trajectories in targeting timely intervention. The aims of this study were to investigate cognitive and motor

Background: Emerging evidence suggests that anterior cruciate ligament (ACL) ruptures can restore ACL fiber continuity. The relationship between ACL continuity on magnetic resonance imaging (MRI) (sign of ACL healing) and outcomes >5 years after an acute ACL rupture has not been investigated. Purpose: This study aimed to (1) describe clinical outcomes and radiographic osteoarthritis (ROA) at 11 ye

The relationship between sustainability and conflict is complex and often hard to define, yet the consequences of interaction can be catastrophic. Unsustainable practices and their consequences for the environment can contribute to conflict. War—and the energy and resource costs of preparing for war—can also have terrible impacts on the environment. In this Voices, we ask how sustainability and en

Increasing CO₂ emission is considered as the main reason for global warming in the world. One of the reasons for producing CO₂ is using of fossil-based materials in the construction projects. This study intends to assess the using bio-based materials instead of fossil-based materials for the thermal insulation layer of the external walls and roofs. Another focus of this project is using green conc

Nonlinear optical response of Au metallic nanoparticles, synthesized and embedded in sapphire by using ion implantation, as a function of their size and shape is studied. The size of the Au NPs was varied by controlling the annealing time of the gold-irradiated sapphire in a reducing atmosphere. Their shape was changed from approximately spherical to prolate by swift heavy-ion irradiation using Si