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Background: Recent genome-wide association studies (GWASs) have reported several genetic variants to be reproducibly associated with type 2 diabetes. Additional variants have also been detected from a metaanalysis of three GWASs, performed in populations of European ancestry. In the present study, we evaluated the influence of 17 genetic variants from 15 candidate loci, identified in type 2 diabet

Objective: To study the long-term effects of a workplace intervention in addition to structured physiotherapy regarding self-reported measures in patients with acute/subacute neck and/or back pain. Design: WorkUp – a cluster-randomised controlled trial in 32 primary care centers in Sweden, from January 2013 through December 2014 (ClinicalTrials.gov ID: NCT02609750). Intervention: Structured physio

Entrepreneurs have certain personality traits that are evaluated by venture capitalists (VCs) when making their investment decision, which have been studied in literature. However, personality traits in ecopreneurs, or sustainable entrepreneurs, that may impact the investment decision of a sustainable venture capitalist (SVC) are not known to have been studied, and therefore warrant research oppor

OBJECTIVE: To determine if beneficial effects of a weight-management program could be sustained for up to 24 months in a randomized trial in an ethnically diverse obese population. PATIENTS AND METHODS: There were 209 obese children (BMI > 95th percentile), ages 8 to 16 of mixed ethnic backgrounds randomly assigned to the intensive lifestyle intervention or clinic control group. The control group

We report on ultrafast spectroscopy study of beta-crustacyanin, the carotenoprotein responsible for the coloration of the lobster shell. beta-Crustacyanin is formed by two closely positioned astaxanthin molecules encapsulated in protein. The 2D electronic spectroscopy together with two-color pump-probe was applied to investigate the electronic structure, the excited-state dynamics, and the influen

OBJECTIVE Growth hormone (GH) deficiency is associated with insulin resistance and diabetes. The aim of the current study was to determine incidence of diabetes during GH replacement therapy (GHRT) and the effect of GHRT on fasting plasma glucose concentrations and HbA(1c) in adult patients with GH deficiency. RESEARCH DESIGN AND METHODS-A total of 5,143 GH-deficient patients (male 49.9%; mean age

Sleep apnea is increasing in prevalence, and is an important cause of cardiometabolic diseases and mortality worldwide. Its only established modifiable risk factor is obesity; however, up to half of all sleep apnea cases may occur in non-obese persons, and hence there is a pressing need to identify other modifiable risk factors to facilitate more effective prevention. We sought to examine, for the

Background: Transcatheter closure of secundum atrial septal defect (ASD) is nowadays the main treatment option in many centers worldwide. In symptomatic infants or in those with certain comorbidities, there is a need for early intervention. Limited data are available about the procedural safety in infants below 15 kg of weight. Methods: Retrospective review of all patients referred to our center f

Background: Epidemiological data indicate decreased risk for development and growth of abdominal aortic aneurysm (AAA)among patients with diabetes mellitus (DM), but DM also goes with increased cardiovascular (CV)morbidity and mortality. We evaluated the effects of DM on mortality and CV morbidity after elective open AAA repair. Methods: This is a nationwide observational cohort study of patients

Behandling av lakvatten inom avfallsdeponierna Syftet med projektet var att utvärdera den faktiska lakvattenreningskapaciteten inom Hedeskogas avfallsanläggning, Skånes län. Målet var även att mäta eventuell bakterieaktivitet i dess dammar, i vilka lakvattnet hanteras. Men vad är då lakvatten? Lakvatten produceras varje gång vatten infiltreras genom ämnen samt när olika sorters substanser samlas Dissolved ammonia is often referred to as one of the major contaminants in landfill leachates. Discharge concentration limits for municipal wastewater treatment plants in Sweden have been tightened in order to meet higher water quality standards. Because of REVAQ, a certification system tailored to ensure better sludge quality, wastewater treatment plants may decide whether to accept leachate from

The understanding of development is changing over time. It came a long way from a simple vision of economic progress to the contemporary human-centred perspective. However, the majority of research on institutional impacts continues to focus exclusively on the economic sphere. Thus, I decided to adopt this theoretical concept in a modern, human-oriented framework and analyse how government quality

The understanding of development is changing over time. It came a long way from a simple vision of economic progress to the contemporary human-centred perspective. However, the majority of research on institutional impacts continues to focus exclusively on the economic sphere. Thus, I decided to adopt this theoretical concept in a modern, human-oriented framework and analyse how government quality

Inom kärnkraftsverken, läkemedelsindustrin, biotekniklaboratorier mfl är det vanligt att det radioaktiva ämnet 14C förekommer i olika former. Inom kärnkraftsverken som en biprodukt vid elproduktion och inom läkemedelsindustrin används det som markör för att studera hur sunbstansen distribueras i kroppen. Genom inandning vid t ex oförsiktighet kan de människor som arbetar med dessa olika substanserWith the help from accelerator mass spectrometry (AMS), hair from workers within the nuclear power industry, pharmaceutical and biotechnology industry has been investigated to see if contamination from 14C. 14C-using companies and nuclear power plants were contacted, volunteers were recruited, who sent in hair samples together with a questionnaire. The samples were washed and prepared for 14C anal

The two main objectives of colon cancer screening programs are to prevent and early detect possible cancers in the medium-risk population. Hence, with this paper, I study the following two questions. First, is the program successful at reducing colon cancer mortality rate? Second, what are the key roles early detection and prevention have in reducing mortality rate? To answer these questions, I us

Based on small to moderate effect sizes for the wide range of symptomatic treatments in osteoarthritis (OA), and on the heterogeneity of OA patients, treatment guidelines for OA have stressed the need for research on clinical predictors of response to different treatments. A meta-analysis to quantify the effect modified by the predictors using individual patient data (IPD) is suggested. The initia

Recent alcohol consumption is all established risk factor for squamous cell carcinoma (SCC) or the upper aero-digestive tract. In contrast, the role or lifetime exposure to alcohol with regard to risk of SCC is not well established. Historical data oil alcohol use are available in 271,253 participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). During 2,330,381 pers

Several studies have reported associations of hypertension with cancer, but not all results were conclusive. We examined the association of systolic (SBP) and diastolic (DBP) blood pressure with the development of incident cancer at all anatomical sites in the European Prospective Investigation into Cancer and Nutrition (EPIC). Hazard ratios (HRs) (95% confidence intervals) were estimated using mu

Background: Recently, some US cohorts have shown a moderate association between red and processed meat consumption and mortality supporting the results of previous studies among vegetarians. The aim of this study was to examine the association of red meat, processed meat, and poultry consumption with the risk of early death in the European Prospective Investigation into Cancer and Nutrition (EPIC)

In this study we approach the recent decline in income inequality in Latin America from the perspective of structural change with a focus on the relative performance of the agricultural sector. Our focus is on the underlying forces implied by Kuznets (1965). We zoom in on the relative performance of agriculture in the development process and the rural-urban duality and pay particular attention to