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The AMP-activated protein kinase (AMPK) is a ubiquitously expressed kinase, which is activated in response to depletion of cellularenergy levels. Once active, it functions to alter cellular metabolism in a way that leads to restoration of energy levels. Therefore,AMPK is described as the key regulator of cellular energy homeostasis. Over the past years, AMPK activation has gained increasingattenti
ConclusionsPaper I: Complications in Extracorporeal Shock Wave Lithotripsy (ESWL): A cohort study, conclusion: We conclude that there are few complications to modern ESWL treatment. 1 Hz should be used to reduce complications (p=0.025). As there is no indication that 1Hz is less effective than 1.5 Hz, this strongly implies that 1 Hz should normally be the frequency used.Success rate with ESWL alon
BACKGROUND: Across low-income and middle-income countries (LMICs), one in ten deaths in children younger than 5 years is attributable to diarrhoea. The substantial between-country variation in both diarrhoea incidence and mortality is attributable to interventions that protect children, prevent infection, and treat disease. Identifying subnational regions with the highest burden and mapping associ
BACKGROUND: Technical applications can promote home-based exercise and physical activity of community-dwelling stroke survivors. Caregivers are often able and willing to assist with home-based exercise and physical activity but lack the knowledge and resources to do so. ActivABLES was established to promote home-based exercise and physical activity among community-dwelling stroke survivors, with s
The last few years has seen the emergence of anti-consumption narratives (Chatzidakis and Lee, 2012; Cherrier, 2009), which contest the marketisation of places, and the way that property and space are currently organised by their exchange values, rather than use values (cf. Visconti et al., 2010). Anti-consumption acts disrupt key social imaginaries of places and are apparent in demonstrations and
Competence in supply chain management (SCM) is a key factor for achieving superior business performance. The top 25 companies identified as having excellent competence in SCM in the annual research reports by AMR Research/Gartner have displayed substantially higher financial results than their competitors. In line with this cognizance, human resources are increasingly viewed as enablers of SCM and
Ida WingrenMilena Arias Schreiber Sebastian LinkeBreaking out of the neoliberal market agenda? Developing expertise to support local coastal community-based fisheries in SwedenFisheries management lays bare many of the tensions and contradictions between community wellbeing and livelihoods on one hand and impositions of neoliberal market approaches to sustainability on the other. This causes probl
Granular media (i.e., assemblies of grains, containing voids), such as sand, are highly complex materials, possessing inherently heterogeneous structure and properties that are manifested by the mobility and interaction of their constituent particles. Despite having been widely studied for centuries (i.e., the study of granular media in modern science essentially begins with the work of Charles-Au
Organisms regularly encounter stressful conditions that negatively affects their fitness. One way to minimize these negative effects is to use cues from the environment in order to develop an appropriate phenotype. Many populations of water fleas (Daphnia spp.) are exposed to algal blooms dominated by toxin- producing cyanobacteria during parts of the summer season, which can reduce growth, reprod
Traditionally, automatic control techniques arose due to need for automation in mechanical systems. These techniques rely on robust mathematical modelling of physical systems with the goal to drive their behaviour to desired set-points. Decades of research have successfully automated, optimized, and ensured safety of a wide variety of mechanical systems. Recent advancement in digital technology ha
Popular Abstract in Swedish Ett biologiskt samhälle definieras av de arter som lever och interagerar på en plats. Platsen kan vara en sjö, en ö eller ett skogsparti. Om det dessutom finns flera platser som arter sprider sig mellan brukar man tala om ett metasamhälle. Idag vet man att både ekologiska och evolutionära processer påverkar metasamhällens uppbyggnad, stabilitet och funktionalitet. DenThis thesis aims to elucidate the link between abiotic and biotic effects and biogeographical contingencies, eco-evolutionary assembly processes, and community structure in a spatially explicit metacommunity framework. To this end, we used structure analysis of naturally sampled and experimentally manipulated marine bacterial communities and mathematical eco-evolutionary modeling and simulations o
Popular Abstract in Swedish Balansen mellan våra energibehov och den energi som konsumeras är ej längre i jämvikt. Därför är jakten på alternativa energikällor nödvändig. Hållbara energikällor erbjuder ett bra alternativ till fossilbränslen. Bland många typer av hållbara energikällor erbjuder solenergi möjligheten för mer energi än dagens konsumtion. Solceller är de smarta verktyg som omvandlar ljThe balance between our demands of energy and the energy we are consuming is not in equilibrium anymore. Therefore, the search for other energy resources is indispensable. Sustainable energy sources offer the alternative to the fossil fuels. Within many types of sustainable energy sources, solar energy offers more than the total global energy consumption. Solar cells are the smart conversion tools
The synthesis of phospholipids with defined fatty acid and polar head composition catalysed by lipases and phospholipases was investigated. Lipases from Rhizopus arrhizus and Candida antarctica were used for the direct acylation of DL-a-glycerophosphate and L-a-glycerophosphatidylcholine, with different fatty acids. Esterification reactions can be carried out in systems with low wate
Popular Abstract in Swedish Avhandlingen handlar om lärares tankar om kompetensutveckling med utgångspunkt i intervjuer med olika lärare vid tre tillfällen under 1990-talet. Lärare utvecklar i lärarutbildning allmänna lärarkunskaper, ämneskunskaper och ämnesdidaktiska kunskaper under 3,5 - 5,5 år, beroende på elevernas åldrar och lärarens ämneskombinationer. I yrkesverksamheten deltar lärare i ettThe development in society and school activities that have taken place during the past twenty years, form the background to the problem in this thesis. Liberal democratisation in the society as a whole and the global explosion of knowledge have made it necessary for teachers continuously to develop new knowledge. The over all aim of the thesis concerned the development of knowledge of variations
Popular Abstract in Swedish Tidigare trodde man att den vuxna hjärnan inte hade någon förmåga att nybilda nervceller. Detta skulle innebära att nervceller aldrig blev ersatta om de skadades eller dog. Nu vet man däremot att den vuxna hjärnan fortfarande producerar nya nervceller från särskilda moderceller, s.k. stamceller, belägna i åtminstone två områden i hjärnan: subgranulära zonen i hippocamThe adult brain constantly produces new neurons from endogenous neural progenitor cells located in at least two regions, the subgranular zone (SGZ) in dentate gyrus of the hippocampus, and the subventricular zone (SVZ). Major efforts are underway to discover the functional significance of new neurons in the adult brain. Several studies have indicated a relationship exists between newborn hippoca
Popular Abstract in Swedish Vi vill bevara naturbetesmarker och deras skönhet, vilken bland annat utgörs av de olika växtarter som förekommer där. Men idag finns det tyvärr inte många betesmarker kvar. Naturbetesmarkerna har under de senaste två sekelerna försvunnit på grund av ökad eller minskad markanvändning, där betesmarker blivit omvandlade till antingen åkermark eller skog. Bristen på betesmLarge areas of grazed, species rich semi-natural grassland were lost in Europe during the last two centuries and as a consequence led to decreases in grassland specialist species. Therefore, today the “restoration” of grassland on previously arable fields is recommended for the protection of grassland specialists. Even “substitute habitats” for lost grasslands are discussed as temporary alternativ
The Ph.D. project concerns itself with curatorial practice, its constituent modalities and potentialities. It consists of both a practical and a theoretical part. These are not separate entities, but immersed in each other. The point of departure is my own practice, but making claims for a general analysis of the politics of exhibition-making. Rather than proving or disproving certain proposition,
Popular Abstract in Swedish Syftet med den här studien var att undersöka det strukturella underlaget för förslagen att makrofager och gaserna kvävemonooxid (NO) och kolmonoxid (CO), som bildas av kvävemonooxidsyntaser (NOS) respektive hemeoxygenaser (HO), är viktiga för att en perifer nerv ska regenerera. Det finns stöd för dessa hypoteser eftersom andra har visat att förhållanden som stör den invThe purpose of this study was to investigate the suggestions that macrophages, and the systems generating nitric oxide (NO) and carbon monoxide (CO), i.e. nitric oxide synthases (NOS) and heme oxygenases (HO), could be important for peripheral nerve regeneration. Immunocytochemistry was used to visualise invading and resident macrophages, inducible NOS (iNOS), two isoforms of HO (HO-1 and HO-2),
Popular Abstract in Swedish Vid hjärtsvikt är hjärtats pumpförmåga nedsatt och kroppens vävnader kan ej förses med tillräckligt mycket blod utan kompensatoriska förändringar i kroppen. Dessa kompensationsmekanismer är kortvarigt ändamålsenliga men skjuter snabbt över målet vid hjärtsvikt och förvärrar istället symptomen. Under de senaste åren har behandlingen av hjärtsvikt därför kommit att inriktAngiotensin-converting enzyme (ACE) inhibitors act by decreasing production of angiotensin II and by potentiating the effects of bradykinin by inhibition of its breakdown. Bradykinin exerts part of its effects via vasodilating prostaglandins. Since the cyclooxygenase (COX)-inhibitors, e.g. aspirin and non-steroidal anti-inflammatory drugs, NSAIDs, block the formation of prostaglandins patients may
Popular Abstract in Swedish Koncentrationer av proteiner i plasma och urin används i ökande utsträckning i diagnostik av njursjukdomar och i studier av den glomerulära barriärens funktion. De viktigaste frågor som behandlats i denna avhandling var: förvaring av urinprover inför efterföljande proteinanalyser, tillämpningar av proteinkoncentrationer i urin och plasma vid hälsa och vid glomerulära (nPlasma and urine concentrations of endogenous proteins are frequently used in the diagnosis of kidney diseases and in studies of glomerular filter function. The main issues addressed in these studies were: storage of urine samples for subsequent protein analysis, use of protein concentrations in urine and in plasma in health and as markers of glomerular diseases, and the application of renal plasm
