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The objectives of the work presented in this thesis have been to develop molecular methods for (i) detection of Clostridium botulinum in food and clinical samples, and (ii) monitoring the expression of the neurotoxin gene, cnt, during different growth phases and under different growth conditions. For the diagnosis of botulism, a real-time PCR-based method including an internal amplification contr
Popular Abstract in Swedish Dödligheten i skador i Sverige har under de senaste årtiondena minskat, en minskning som idag dock har planat ut. Antalet dödade i transportolyckor och i arbetsplatsolyckor i Sverige har minskat under de senaste 40 åren vilket kan ses som ett resultat av ett effektivt säkerhetsarbete. När det gäller fallolyckor så har däremot andelen som dör av sina skador ökat markant Injuries are often associated with long-term suffering and lowered functioning, and personal injuries impose a huge burden on medical care and health services in addition to the costs associated with impaired functional ability. Each year in Sweden, falling accidents are experienced by a third of those aged 60 or over and half of those aged 80 or over, while injuries from traffic accidents still a
Popular Abstract in Swedish Avfallshantering ägnas nuförtiden ett ökande intresse. Detta verk syftar till att analysera hur vanligt förekommande företagsekonomiska modeller och metoder liksom principen om att förorenaren betalar (The "Polluter-Pays Principle" (PPP)), generellt kan appliceras på management av avfallshantering och specifikt på segregering av olika avfallsfraktioner i syfte att medgeIncreased attention is nowadays devoted to waste management. The objective of this work is to analyse how commonly known business economic models and methods, as well as the Polluter-Pays Principle, can be applied to waste management in general and to waste fractionation in particular, so as to facilitate environmental optimisation of industrial and construction waste fractionation. In discussing
IMPORTANCE: Little is known about whether the duration of adjuvant imatinib influences the prognostic significance of KIT proto-oncogene receptor tyrosine kinase (KIT) and platelet-derived growth factor receptor α (PDGFRA) mutations. OBJECTIVE: To investigate the effect of KIT and PDGFRA mutations on recurrence-free survival (RFS) in patients with gastrointestinal stromal tumors (GISTs) treated wi
Background: With a yearly incidence of 56 per 100,000 inhabitants, colorectal cancer (CRC) is one of the most common malignancies in the Western world, representing the third leading cause of cancer-related mortality. Within three years after the diagnosis of CRC, 29% of patients will have developed liver metastases. Liver resection is a possibly curative treatment, and several preoperative strate
Baltoskandien utgör en del av paleokontinenten Baltica, vilken mestadels var täckt av ett grunt epeiriskt hav under den ordoviciska tidsperioden (ca 485,5–444 Ma). Detta uråldriga hav efterlämnade en tunn lagerföljd av sedimentära bergarter. Under tidig–mellanordovicium (ca 485,5–457,5 Ma) befann sig Baltica vid tempererade breddgrader på södra halvklotet och kallvattenkarbonater bildades över stoThe Baltoscandian region forms part of the paleocontinent Baltica, which was largely covered by a shallow epeiric sea throughout much of the Ordovician (c. 485.5–444 Ma). This ancient sea is today recorded by a thin succession of sedimentary rocks. During the Early–Middle Ordovician (c. 485.5–457.5 Ma), Baltica was situated in mid-latitudes on the southern hemisphere and cool-water carbonates form
Klimatförändringar förväntas leda till längre brandperioder och ökad brandrisk. I Sverige, där homogen produktionsskog utgör största delen av landskapet, finns ett behov av bättre förståelse för skogens mottaglighet för bränder för att kunna mildra risker. I denna avhandling avser skogsbrandmottaglighet sannolikheten för att skogen brinner efter att antändning har ägt rum och inledande brandspridnClimate change is expected to result in longer fire seasons and increased fire risk. In Sweden, where homogenous production forest makes up the majority of the landscape, there is a need for better understanding of forest fire susceptibility in order to mitigate risk. In the context of this thesis forest fire susceptibility is the likelihood of forest burning after ignition and initial fire propag
Den ekonomiska brottsligheten har fått en allt mer markant roll i dagens rättssamhälle. Brottslighet som förövas inom bolag blir allt mer av ett samhällsproblem, inte minst när det gäller brottslighet i organiserad form. Av allt större vikt blir då hur man ställer de personer som begår brott inom ett bolag till ansvar för sina gärningar. Utifrån detta syfte har principen om företagaransvar tillkEconomic crime has played an increasingly significant role in our modern society. Crime perpetrated within companies are becoming more of a social problem, not least when it comes to organized crime. It has become of greater importance, how to hold the persons who commit crimes within a company accountable for their deeds. Based on this purpose, certain principles for criminal responsibility with
Background The Meta-Analysis of Radiotherapy in squamous cell Carcinomas of Head and neck (MARCH) showed that altered fractionation radiotherapy is associated with improved overall and progression-free survival compared with conventional radiotherapy, with hyperfractionated radiotherapy showing the greatest benefit. This update aims to confirm and explain the superiority of hyperfractionated radio
2024 godkände Lunds kommun en ny strategi för utveckling av Lunds stadskärna. I strategin läggs ett anmärkningsvärt förslag fram: att ta bort de vanliga stadsbussarna från stadskärnan, och ersätta dem med lokala minibussar. Små stadskärnebussar är i sig inget nytt koncept, men fungerar vanligen som ett komplement till den ordinarie kollektivtrafiken; inte som en ersättning. Studier av jämförbara lIn 2024, Lund municipality approved a new strategic document about enhancing the city centre of Lund. In this document, a questionable suggestion is put forth: to replace the buses serving the city centre with minibuses. City centre minibuses is not an entirely new concept; however, it is conventionally used as a complement to ordinary buses rather than as a replacement. Studies on similar measure
Den snabba tekniska utvecklingen rörande artificiell intelligens öppnar upp för många juridiska frågor, inte minst vad rör upphovsrätt. I syfte att kunna gene-rera material med hjälp av artificiell intelligens krävs det att tillhandahållare av AI har tillgång till stora mängder data, för att kunna träna upp dessa till att producera resultat som efterliknar mänskliga verk. Frågan som därigenom uppsThe rapid technological development of artificial intelligence gives rise to nu-merous legal issues, particularly concerning intellectual property. For artificial intelligence to generate material, it must be trained on human-created works to produce results that resemble such. This process requires access to large vol-umes of data, often sourced from the internet and large databases. The ques-tio
Objective: This study primarily aimed to comprehensively characterize the neurological, neuroradiological and neurocognitive profiles, as well psychiatric features of individuals with Spinocerebellar Ataxia Type 34 (SCA34) associated with pathogenic variants in the ELOVL4 gene. Secondarily, we investigated the relationship between neurocognitive functions and cerebellar morphology in individuals w
Electrospun nanofiber membranes (ENMs) with unique porous 3D network structure exhibit properties such as high porosity and surface area, fine-tuned surface functionality and uniform pore sizes. This makes them candidates for water/wastewater applications with excellent flow. This study focuses on the fabrication of polymeric and composite ENMs from polyacrylonitrile (PAN) and nanoclay (NC) and th
Popular Abstract in Swedish Denna avhandling berör storskalig genetisk variation och fylogeni hos arterna i växtsläktet Alisma (svaltingar). Den naturliga utbredningen för detta släkte av vatten- eller sumpväxter inskränker sig till norra halvklotets tempererade områden. Den vanligaste arten i större delen av Europa är Alisma plantago-aquatica (svalting eller kranssvalting som den ibland också kalIn the present thesis the phylogeny and patterns of genetic diversity of the plant genus Alisma (Alismataceae) were investigated by means of genetic markers (RAPDs, allozymes, and ITS and trnL sequences). Additionally, morphological studies were carried out in paper IV. All species in the genus were found to be closely related to each other and two major groups of diploid taxa were found: one cont
Innovation is an interactive learning process that is facilitated naturally by geographic proximity. Innovation intermediaries can serve as an extra catalyst to and facilitator of interaction and collaboration. With today’s more globalized knowledge and innovation landscape, companies and research organizations seek complementary competencies and partners with whom they can collaborate on a much b
Extracorporeal adsorption (ECAT) is a novel strategy to reduce activity in whole body (WB), blood and radiosensitive organs by removing the excess of radiolabeled and biotinylated monoclonal antibody (MAb) from blood so that tumor/normal tissue ratio (T/N) could be improved. By increasing T/N, higher amounts of radiolabeled MAb might be administered, making it possible to treat disseminated carcin
Popular Abstract in Swedish Dieselmotorn, uppkallad efter sin uppfinnare Rudolf Diesel, patenterades 1892 och har sedan dess bidragit väsentligt till utvecklingen av samhället. Den viktigaste användningen är som kraftkälla i fordon och detta användningsområde ökar fortfarande. Andelen dieselmotorer i nyregistrerade personbilar i Västeuropa har nyligen passerat 50 %. För kommersiella fordon som lasThis project deals with questions related to generic diesel combustion research and optically accessible engines are used to study the combustion process. Images of the combustion are analyzed together with in-cylinder pressure and exhaust gas emission measurements. The results can be divided into two main categories: one about evaluations of optically accessible engines and one about studies of e
This thesis is based on three scientific papers dealing with different models for coordinated control of multi-stage inventory systems. The ability to control multi-echelon inventory systems, is paramount for reducing tied up capital and inventory costs in large distribution systems. It is also one key issue in achieving efficient supply chain management. We focus our attention on a general distr
