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Background: Transcription factors play a key role in lineage commitment and differentiation of stem cells into distinct mature cells. In hematopoiesis, they regulate lineage-specific gene expression in a stage-specific manner through various physical and functional interactions with regulatory proteins that are simultanously recruited and activated to ensure timely gene expression. The transcripti

Monapostrukturen ligger i Nampula provinsen i norra Moçambique, och utgör en del av Mocambique bältet. Strukturen är ca 35-40 km i diameter och har en mycket låg topografi. Trots detta syns den väl på satellitbilder och flygfotografier. Relationer mellan samt utbredning av de enskilda bergartsleden är inte helt klarlagd och frågor såsom transportriktning, litostratigrafisk uppdelning samt tektonisThe Monapo Structure is situated in the Nampula Subprovince in northern Moçambique, and makes up a part of the Moçambique Orogenic Belt. It is a 35 x 40 km subcircular structure, with a very flat topography, and it clearly shows up on aerial photos. The regional setting of the Monapo Structure is not yet clearly settled and many questions regarding transportation directions, lithostratigraphic gro

Abstract: Total phosphorus (TP) concentration changes from 1990 to 2012 in acidified and limed lake group in Sweden were investigated and compared to neutral lake group. The Literature study showed that TP concentrations were generally reduced in acidified lakes due to reduced terrestrial losses of P into lakes, increased in-lake P precipitation and burial, and weakened biological P cycling. Altho

Per- and polyfluoroalkyl substances (PFAS) are persistent synthetic chemicals widely used in consumer and industrial products. Increasing evidence of their adverse health effects has intensified the need to understand their impact on human immune function. This study assessed PFAS toxicity using a human dendritic cell model by focusing on gene expression and surface marker modulation, as well as a

Surfaktanter används inom många applikationer idag för att stabilisera eller förbättra proteiners funktion. Kartläggning av hur surfaktanter interagerar med proteiner påbörjades redan för flera årtionden sedan, men är ännu inte fullständig. Genom att förstå detta bättre kan surfaktanters användningsområden effektiviseras ytterligare och få produkter som läkemedel och rengöringsmedel som är effektiToday, proteins are used in a huge variety of industrial application ranging from detergents and pharmaceuticals to cosmetical products. Surfactants have the potential to increase solubility of poorly soluble protein, as well as hindering proteins in formulation to interact with the interface and thus protecting them from degradation. Even if the use of protein-surfactant system dates back decades

Introduction: Achieving and retaining a low background signal is essential for analytical techniques, especially for extremely accurate systems such as supercritical fluid chromatography (SFC) coupled with high-resolution mass spectrometry (HRMS) since the limits of detections are heavily dependent on the background signal. Background: A standard option to ensure a low background signal is the usa

The aim of this study is to reveal how the oil-in-water interface of triolein emulsions in aqueous solutions is affected by the lipase activity when using five different surfactants as emulsifiers. For this purpose Dynamic Light Scattering (DLS) and Small Angle X-ray Scattering (SAXS) were applied. Lipases are enzymes that catalyses the hydrolysis of ester bonds of lipids, i.e lipolysis, and act a

Metabolic syndrome and diabetes impact brain function and metabolism. While it is well established that rodents exposed to diets rich in saturated fat develop brain dysfunction, contrasting results abound in the literature, likely as result of exposure to different high-fat diet (HFD) compositions and for varied periods of time. In the present study, we investigated alterations of hippocampal-depe

Atmospheric new particle formation (NPF) is an important phenomenon in terms of global particle number concentrations. Here we investigated the frequency of NPF, formation rates of 10 nm particles, and growth rates in the size range of 10–25 nm using at least 1 year of aerosol number size-distribution observations at 36 different locations around the world. The majo

An extended version of a numerical model introduced by Larson et al. (2013) to simulate long-term cross shore material exchange for the subaqueous portion of the profile has been developed. Efforts have focused on improving the model to better account for beach systems consisting of two bars (inner and outer bar), as well as simulating the feeder response over time of nearshore dredged material ba

Experimental studies suggest that hepatocyte growth factor (HGF) and its transmembrane tyrosine kinase receptor, Met, in part also relying on Akt kinase activity, mediate radioresistance. We investigated the importance of these biomarkers for the risk of ipsilateral breast tumour recurrence (IBTR) after adjuvant radiotherapy (RT) in primary breast cancer. HGF, phosphorylated Met (pMet) and phospho

Pelvic floor reconstructive surgery (PFRS) has suffered from high recurrence rates ever since its birth. Implants were thus quickly employed, initially autologous grafts and allografts. Technological development led to the manufacturing of synthetic implants that were believed to provide the support needed during urinary incontinence and pelvic organ prolapse (POP) surgery. However, due to a surge

BACKGROUND: Transportation noise is increasingly acknowledged as a cardiovascular risk factor, but the evidence base for an association with stroke is sparse. OBJECTIVE: We aimed to investigate the association between transportation noise and stroke incidence in a large Scandinavian population. METHODS: We harmonized and pooled data from nine Scandinavian cohorts (seven Swedish, two Danish), total

Methanol is an alternative fuel offering a lower well-to-wheel CO2 emission as well as a higher efficiency, given that the fuel is derived from biomass. In addition to reduced CO2, methanol does not emit soot particles when combusted which is a great advantage when attempting to reduce NOX levels due to the effectively non-existing NOX-soot trade-off. The engine setup used was a Scania D13 engine

23 oktober 2026 13:00 | Halvtidskontroll Title: Outcomes in patients on long-term oxygen therapyMain supervisor: Magnus Ekström (Lund University)Reviewers: Thomas Ringbaek (University of Copenhagen), David Erlinge (Lund University), Adriana Hiller (Lund University)AbstractBackgroundLong-term oxygen therapy (LTOT) is an established treatment form used to prolong life in patients with severe hypoxem

https://www.intramed.lu.se/evenemang/filip-bjorklund-institutionen-kliniska-vetenskaper-lund - 2026-06-22

Most studies of life quality are concentrated on a country-level scale, while local differences within a country or area are less studied. Thus, the effect of the environment on life quality on a local scale remains understudied and is often represented by one generalized common factor. In this study, we investigated the effect of an objectively measured environmental quality variable and subjecti

Background: The association between protein intake and prostate cancer risk remains unclear. Aims: To prospectively investigate the associations of dietary intakes of total protein, protein from different dietary sources, and amino acids with prostate cancer risk and mortality. Methods: In 131,425 men from the European Prospective Investigation into Cancer and Nutrition, protein and amino acid int

BACKGROUND: Low anterior resection syndrome is common after sphincter-sparing surgery, but it is unclear to what extent anastomotic leakage after anterior resection contributes to this condition. OBJECTIVE: The aim of this study is to assess the long-term effect of anastomotic leakage on the occurrence of major low anterior resection syndrome. DESIGN: This is a retrospective observational cohort s

Despite some epidemiological evidence on the protective effects of polyphenol intake on epithelial ovarian cancer (EOC) risk from case-control studies, the evidence is scarce from prospective studies and non-existent for several polyphenol classes. Therefore, we aimed to investigate the associations between the intake of total, classes and subclasses of polyphenols and EOC risk in a large prospect