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OBJECTIVE: In this observational longitudinal study we estimate knee joint cartilage glycosaminoglycan (GAG) content, in patients with an acute anterior cruciate ligament (ACL) injury, with or without a concomitant meniscus injury. METHODS: 29 knees (19 men/10 women) were prospectively examined by repeat delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC), approximately 3

Chronic myeloid leukemia (CML) is genetically characterized by the Philadelphia (Ph) chromosome, formed through a reciprocal translocation between chromosomes 9 and 22 and giving rise to the constitutively active tyrosine kinase P210 BCR/ABL1. Therapeutic strategies aiming for a cure of CML will require full eradication of Ph chromosome-positive (Ph(+)) CML stem cells. Here we used gene-expression

Postmenopausal overweight women have an increased risk of breast cancer. The link between obesity and breast cancer could be mediated through hyperinsulinemia. Insulin and insulin-like growth factor-1 (IGF-1) stimulate mammary cell proliferation in vitro, and cell proliferation is directly linked to the risk of breast cancer. Our objective was to investigate the relationship between breast cancer

In spite of its immune privileged state, xenotransplantation within the CNS is associated with rapid graft destruction in immunocompetent hosts. Efforts to enhance graft survival have mostly focused on host immune response, whereas relatively little attention has been paid to donor tissue characteristics. In the present paper, we explore long-term survival of xenogeneic full-thickness neuroretinal

Background Pulmonary vein (PV) potentials are invariably recordable at the PV ostia in patients with atrial fibrillation (AF) and delayed conduction around the PV ostia may play a role in the initiation and maintenance of AF. Aims To investigate the presence and extent of PV potentials in patients with and without AF. Methods and results Circumferential catheter recordings at the PV ostia were obt

Background: Several countries are discussing new legislation on the ban of smoking in public places, and on the acceptable levels of traffic-related air pollutants. It is therefore useful to estimate the burden of disease associated with indoor and outdoor air pollution. Methods: We have estimated exposure to Environmental Tobacco Smoke (ETS) and to air pollution in never smokers and ex-smokers in

In the Tunisian semiarid area, water erosion processes have led to negative economic and environmental consequences in a context of limited water resources. To characterize and predict these degradation phenomena, a comprehensive high-resolution data base on erosive rainfall, together with siltation records for 28 small reservoirs were analyzed. The studied small reservoir network displays a gener

Global climate projections forecast more frequent, intense and longer heat waves in the decades ahead. Heat waves are considered the most dangerous extreme weather event for human health, with impacts most pronounced in cities because of the urban heat island effect. Heat-related mortality rates are highest in certain at-risk populations, like the elderly. Toronto, Canada’s largest city, faces two

Grooming är en systematisk process, som för det första kränker barn och för det andra möjliggör att barn kan utsättas för fysiska övergrepp. Barn blir lurade särskilt av gärningsmän då de inte har samma skyddsmekanismer och riskmedvetande som en vuxen person. Kommunikationsteknologins framväxt under 2000-talet har utökat möjligheterna för vuxna som vill ta kontakt med barn i sexuellt syfte. År 200Grooming is a systematic process, which firstly violates children, and secondly enables children to be subjected to physical forms of abuse. Children are deceived especially as they lack the same psychological safety mechanisms and risk awareness as that of an adult. The growth of communications technology during the 21st century has increased the possibilities for adults that seek contact with ch

Skönhetsingrepp kan leda till skador eller missnöje med det estetiska resultatet. Det har länge funnits kritik mot att skönhetsbranschen saknar ett anpassat och tydligt regelverk. Syftet med uppsatsen är därmed att utifrån en rättsanalytisk metod undersöka och problematisera möjligheten till ansvarsutkrävande vid felaktiga skönhetsingrepp som har genomförts i Sverige. Min första frågeställning b

Aktiebolag är i behov av kapital. Detta beror dels på ett lagstadgat krav om att alla aktiebolag måste inneha ett aktiekapital, dels på att olika affärsprojekt och investeringar kostar pengar. Det finns nackdelar med samtliga befintliga finansieringsalternativ. Av denna anledning utreds i detta arbete, med användande av den rättsdogmatiska metoden, om en alternativ lösning för kapitalanskaffning iLimited companies are in need of capital. This is partly due to the statutory requirement that all limited companies must hold a share capital, but also because of the fact that different business projects and investments cost money. The existing financing options all have some disadvantages. As a result, this essay investigates an alternative solution for the raising of capital in limited compani

I samband med den nya samtyckeslagstiftningen uppstod diskussioner kring åklagarens bevisbörda. Syftet med uppsatsen är att klargöra om bevisbördan påverkats av den nya lagstiftningen. Straffbestämmelsen om våldtäkt i sin nya lydelse innebär att gränsen mellan en straffri och straffbar gärning går vid om deltagandet i den sexuella handlingen är frivilligt. Ett frivilligt deltagande ska ha kommit tIn connection with the new Swedish consent legislation, discussions arose around the prosecutor's burden of proof. The purpose of this paper is to clarify whether the burden of proof is affected by the new legislation. The punishment clause on rape in its new wording means that the boundary between a non-punishable and a criminal act goes on if participation in the sexual act is voluntary. Vol

Culinary herbs are fragrant plants that are used to enhance the flavour of dishes. They are highly perishable food products susceptible to microbial spoilage. One technique widely used to extend their shelf life is drying. However, during this process, aromatic compounds are lost and changes in colour and texture occur. This thesis investigates the effect of tissue impregnation with hypertonic sol

Krita-paleogen-gränsen har länge varit central i diskussioner mellan forskare runt om i världen, då den markerar/sammanfaller med utdöendet av 75% av jordens arter till följd av ett enormt asteriodnedslag på Chicxulúbhalvön i Mexiko. Gränsintervallet är vida utbrett i sedimentära lagerföljder som bildades under denna tid, och kan identifieras genom sina unika kemiska egenskaper och karakteristiskaThe Cretaceous-Paleogene boundary has long been a center of discussion amongst scientists as it marks the extinction of 75% of all species on Earth. This mass extinction event was probably caused by an enormous asteroid impact event in what is now Mexico. The boundary interval is easily identified in the sedimentary geological record because of its unique chemical properties as well as its charact

This study is based on the reflections that society's activities have a negative impact on the climate and that there are planetary boundaries that need to be taken into account if ecological sustainability will have a chance to be achieved. Today the Swedish housing sector is quite resource intensive and contribute to about 20 percent of the Swedish emissions of carbon dioxide, which is about

Genome-wide association studies (GWAS) have identified more than 50,000 SNP-trait associations. Most of these SNPs or genetic variants map to noncoding regions, known as or gene desserts. This makes it challenging to describe the mechanism by which the variant confers susceptibility to the trait. Increasingly, there is an interest in characterization and interpretation of the effect of non-coding

En växande världsbefolkning, politiska regleringar och en strävan att öka andelen energi från förnyelsebara källor har resulterat i att intresset för vindkraftsverk ökat. Winfoor AB utvecklar `Triblade’, en ny teknologi för vindkraftsverksblad som ämnar öka effekten samtidigt som bladen kan göras lättare, billigare och enklare att transportera än dagens vindkrafsverksblad.A globally growing population, an increased energy consumption and growing environmental awareness have made the interest for renewable energy sources, such as wind power, higher. As a result of the increased demand the need for new and improved technologies have increased. The energy production of a wind turbine is highly affected by the rotor blade length, which is limited by the massive dead lo

I Sverige finns ett grundlagsstadgat skydd mot påtvingade kroppsliga ingrepp som omfattar i princip alla ingrepp som görs i hälso- och sjukvård. Det innebär att all hälso- och sjukvård måste ges med patientens samtycke eller med stöd i tvångslagstiftning. I dagsläget finns ingen möjlighet att ge vård till en patient som saknar kapacitet att lämna ett giltigt samtycke om inte tvångslagstiftningen äThe Swedish constitution provides a general protection against enforced interventions. This includes practically all interventions in healthcare. The result is that all medical interventions must be supported by the patient's consent or by law. Swedish law provides no solution if a patient lacks the mental capacity to give consent for an intervention and the laws regarding involuntary treatmen

Inclusion in the digital society can lead to improved communication and access to information which increases informed decision making and productivity for individuals and businesses. In turn, this has a positive effect on the socio-economic development of a country. Worldwide, more women than men lack the knowledge of, and access to, Information and Communication Technologies (ICT) such as comput