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23 October 2026 13:00 | Halvtidskontroll Title: Outcomes in patients on long-term oxygen therapyMain supervisor: Magnus Ekström (Lund University)Reviewers: Thomas Ringbaek (University of Copenhagen), David Erlinge (Lund University), Adriana Hiller (Lund University)AbstractBackgroundLong-term oxygen therapy (LTOT) is an established treatment form used to prolong life in patients with severe hypoxem

https://www.intramed.lu.se/evenemang/filip-bjorklund-institutionen-kliniska-vetenskaper-lund - 2026-06-12

Objective: Ovarian carcinoma (OvCa) is more common in the elderly, but also affects the adolescent and young adult (AYA) generation, which refers to those aged 15–39 years. Although the characteristics of OvCa may differ between AYAs and non-AYAs, limited information is currently available on differences in prognostic factors. Therefore, we herein investigated prognostic factors for and the progno

BACKGROUND: Cognitive impairment is a serious comorbidity in heart failure patients, but effective therapies are lacking. We investigated the mechanisms that alter hippocampal neurons following myocardial infarction (MI).METHODS: MI was induced in male C57Bl/6 mice by left anterior descending coronary artery ligation. We utilised standard procedures to measure cystic fibrosis transmembrane regulat

BACKGROUND: Breast-conserving surgery followed by radiotherapy is part of standard treatment for early-stage breast cancer. Hypoxia is common in cancer and may affect the benefit of radiotherapy. Cells adapt to hypoxic stress largely via the transcriptional activity of hypoxia-inducible factor (HIF)-1α. Here, we aim to determine whether tumour HIF-1α-positivity and hypoxic gene-expression signatur

This article investigates the impact of climate policies on electoral support for governing parties in Sweden through mixed methods combining a sentiment analysis of news articles and regression discontinuities of voter support over time. The regression discontinuity models indicate that the effects of climate policies on government support are not robust and are spurious across different model sp

BACKGROUND: Little is known about whether the recommended, non-pharmacological treatments for chronic pain yield reductions in healthcare utilization, social costs and increased productivity in actual practice.METHODS: The primary aim of this study ( n = 232) was to conduct secondary analyses of health economic outcomes using data from national registries combined with clinical outcome data from a

The global food system, population growth, increased wealth, shifting diets and an overall larger demand for processed food, meat and dairy, has led to increased pressure on land, water and energy. The environmental implications of this have taken part in the establishment of international institutions which aims to regulate agriculture production methods, and thereby reduce these adverse impacts.

Internetlänkar – såsom hyperlänkar och inlinelänkar – är centrala inom internet och World Wide Web (”nätet”). Länkning förenklar navigering på nätet och informationssökning till den grad att det är svårt att föreställa sig ett nät utan dem. Upphovsrättsinnehavarens rätt till överföring av verket till allmänheten är en exklusiv, ekonomisk rättighet. Varje ny överföring av verket till en publik måsIn the context of the internet and the World Wide Web, the position of links – such as hyperlinks and embedded links – is essential. Linking facilitates web navigation and information retrieval to a point where it is difficult to conceive of a web without them. The copyright holder’s right of communication of the work to the public is an exclusive, economic right. Each new act of communication of

Background: Neuroblastoma is the commonest extracranial solid tumor of childhood, yet rare, and with poor survival before 1990, especially for high-risk disease; thus, information on late effects is sparse. With great advances in cancer treatment, survival has reached 80% in the Nordic countries. The aim of the study was to investigate the risk of developing neurologic disorders after neuroblastom

Study Design: This is a cross-sectional study. Objectives: To describe the association between cardiovascular risk factors (body mass index (BMI), waist circumference (WC), blood pressure, blood glucose and lipids) and leisure time physical activity (LTPA) in older adults with long-term spinal cord injury (SCI). Setting: Community settings, southern Sweden. Methods: Data from the baseline data col

Context: This review focuses on positive surgical margins (PSM) in radical prostatectomy (RP). Objective: To address the etiology, incidence, and oncologic impact of PSM and discuss technical points to help surgeons minimize their positive margin rate. An evidence-based approach to assist clinicians in counseling patients with a PSM is provided. Evidence acquisition: A literature search in English

Abstract Objective. Our aims were to investigate the natural history of biopsy-proven non-alcoholic fatty liver disease (NAFLD) in Sweden, its associated complications, the clinical and biochemical factors associated with more advanced liver disease and the survival rate with a mean follow-up time of 27 years. Material and methods. All subjects participating in the population-based prospective coh

Objective. Recent evidence suggests that hematopoietic stem cells (HSCs) in the bone marrow (BM) are located in areas where the environment is hypoxic. Although previous studies have demonstrated positive effects by hypoxia, its role in HSC maintenance has not been fully elucidated, neither has the molecular mechanisms been delineated. Here, we have investigated the consequence of in vitro incubat

Objective: To investigate the mortality rate and possible early predictive factors of mortality after 19-23 years in a cohort of patients with rheumatoid arthritis (RA) followed prospectively from disease onset. Patients and methods: A community-based cohort of 183 patients (63% female) with RA and disease duration < 2 years was recruited 1985-1989. The patients were followed yearly from diagnosis

It is widely accepted that firms in peripheral regions benefit to a lesser extent from local knowledge spillovers than firms located in agglomerations or industrial clusters. This paper investigates the extent to which innovative firms in peripheral regions compensate for the lack of access to local knowledge spillovers by collaborating at other geographical scales. So far the literature predomina

Objective The NORAM (Nonrenal Wegener's Granulomatosis Treated Alternatively with Methotrexate [MTX]) trial demonstrated that MTX can replace cyclophosphamide (CYC) as remission-inducing treatment for patients with newly diagnosed early systemic antineutrophil cytoplasmic antibodyassociated vasculitis. Duration of relapse-free survival was longer among CYC-treated patients than among MTX-treated p