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Projects in the space domain are extremely complex and often characterized as being “one-off”, which makes it very difficult to make good predictions on future developments. Furthermore, space projects are also associated with state-of-the-art technology, high costs and long development time. Risks are therefore a threat to project success because they may have negative effects on the project cost
Problem definition: Companies competing in a market environment are trying to improve their competitiveness. A widespread company strategy is to focus on the core operations and competencies and outsource non-core activities. Managing companies’ vehicle fleets is often considered non-core operations which have led to the creation of the operational vehicle leasing industry. It means that the leasi
BACKGROUND: Children, adolescents, and young adults with cancer (referred to as CAYAs) are at risk of long-term health complications, with cardiovascular disease (CVD) being a major concern. In addition, sociodemographic characteristics and traditional cardiovascular risk factors may also contribute to disparities in outcomes compared with those of the general population. The aim of this study was
Alpha-synuclein phosphorylated at serine 129 (S129) is highly elevated in Parkinson's disease patients where it mainly accumulates in the Lewy bodies. Several groups have studied the role of phosphorylation at the S129 in alpha-synuclein in a rat model for Parkinson's disease using recombinant adeno-associated viral (rAAV) vectors. The results obtained are inconsistent and accordingly the role of
Objective: The aim of the study was to investigate if time to start chemotherapy (TTC) after primary debulking surgery (PDS) impacted relative survival (RS) in advanced epithelial ovarian/fallopian tube/primary peritoneal cancer (EOC). Methods: Nationwide population-based study of women with EOC FIGO stages IIIC-IV, registered 2008–2018 in the Swedish Quality Register for Gynecologic Cancer, treat
Popular Abstract in Swedish Försök att föreställa dig något som är så litet att det inte går att se i ett mikroskop, något som är betydligt mindre än både DNA och protein. Det är sådana molekyler jag har jobbat med i mitt avhandlingsarbete. Dessa små molekyler kallas mikroRNA och finns i alla celler och har betydelse för hur en cell uppför sig. De kan till exempel styra bildandet av nya nervcellerOnly a few decades ago, it was generally believed that gene expression was controlled in a unidirectional way, i.e. DNA was transcribed into RNA, which simply acted as a messenger molecule used to produce the protein that executed cellular functions. It was not until the 1970-80’s that RNA interference was proclaimed as a gene regulatory process, and now it is increasingly evident that non-coding
Piratverksamhet är inte speciellt uppmärksammat i västvärlden – media lyfter inte upp det och det är heller inte en speciellt prioriterad punkt på politikernas agenda. Det betyder dock inte att det inte är ett stort problem. Det påverkar många, både känslomässigt och ekonomiskt, på en individnivå men också på en nationell, regional och global nivå. Problemet är komplext och har en lång historia,
Användandet av varumärken har gått från att enbart vara ett sätt att ange kommersiellt ursprung till att även kunna förmedla en image och vara ett sätt att marknadsföra sig. På grund av den stora mängden varumärken i dagens samhälle har nya vägar för att kunna skilja sig från mängden varit tvungna att finnas, vilket har lett till en ökad användning av okonventionella varumärken, exempelvis dofter.The use of trademarks has gone from just being a means to indicate commercial origin towards a way to market your brand and convey an image. Because of the large number of trademarks in the society of today new ways to stand out have had to be found, which has led to an increased use of unconventional trademarks, for example scents. A trademark may consist of any sign, particularly words, includin
Bestämmelser om tvångslikvidation av aktiebolag vid kapitalbrist har sedan länge reglerats i svensk rätt. Bestämmelsernas övergripande syfte är att utgöra en gräns för hur långt en förlustbringande verksamhet får fortsätta innan verksamheten måste upphöra genom likvidation. På så sätt skyddas bolagsborgenärerna mot att bolagets hela kapital konsumeras innan avveckling av bolaget inleds. Som ett påProvisions regarding involuntary liquidation of companies, due to capital deficiency, have been enforced under Swedish regulation for a long period of time. The overall purpose of the regulation is to set a limit on the time period an unprofitable company may continue to trade before its operations must cease through liquidation. Thus, protecting the creditors of the company from a situation where
I Sverige råder allmän vittnesplikt vilket innebär att ett kallat vittne har en skyldighet att vittna. Ett vittne kan således inte undvika vittnesplikten så länge någon av undantagsreglerna inte är tillämpliga. Att vara rädd för att vittna på grund av att vittnet blivit utsatt för hot eller våld är inte en giltig anledning till att inte vittna. För de fall ett kallat vittne inte fullgör sin vittne
Research needs: Glass has been used for a long time, mostly in the window and packaging industry, but lately architects and design engineers have become more and more interested in glass as a load-bearing (building) material. It has become a challenge to use less other materials in the glass-structures or at least not to let it show too much. One area of big interest is bolt fixings. Design engine
As aerosol particles are important for global climate effects, their sources and influence on global aerosol particle concentrations need to be quantified. One of the major aerosol sources in the atmosphere is new particle formation (NPF) of new nanometer sized particles in the atmosphere. The influence on the global aerosol concentration due to NPF events is however not well quantified. The goals
Swedish buildings, which were built in the early 60: s to mid 70: s are in great need of a restoration. Not least in view of the considerable quantities of energy that the buildings consume, this is partly due to the end of life in building components. Energy which in the worst case is obtained from non-renewable energy sources, which in turn generates significant carbon dioxide emissions worldwid
“I had a prison in my heart” – an analysis of a life story of a former criminal. The purpose of this study was to investigate stories featured in an autobiography written by a former criminal, based on theories of social psychology and interactionism. More specifically the aim was to study the reasoning and motives in the stories regarding the person’s relationships with significant others during
In this work, the spatial extent of new particle formation (NPF) events and the relative probability of observing particles originating from different spatial origins around three rural sites in eastern China were investigated using the NanoMap method, using particle number size distribution (PNSD) data and air mass back trajectories. The length of the datasets used were 7, 1.5, and 3 years at rur
This thesis makes a contribution to matching theory and mechanism design. It consists of four self-contained papers focusing on kidney exchange, object allocation and partnership formation. The first paper, Pairwise Kidney Exchange over the Blood Group Barrier, investigates how the use of immunosuppressive drugs can be implemented within kidney exchange programs. Thanks to advances in medicine, im
Retail and cities have had a long and intertwined history together. Since the beginning of first cities established, being a hub for commercial exchange has been one of the main elements what makes a city (Söderlind, 2011). Nevertheless, since 1980s, there have been some substantial shifts at the global scale regarding the organization of retail, and in turn, its spatial manifestations in the citi
Aim: This study investigates the effect of time and age on health-related quality of life, general self-efficacy, and functional level 12 months following dysvascular major lower limb amputation (LLA). Methods: A prospective cohort study design with assessments at baseline and follow-up 3, 6, and 12 months post-amputation. Data were collected via in-person interviews using Short Form 36, the Gener
Multi-proxy analysis was performed on a radiocarbon-dated core, collected from a relic oxbow lake in the Limpopo River-plain, Mozambique, with the aim to reconstruct paleo-environment and past flooding of the lower river system over the past c. 800 years. An additional objective was to evaluate and investigate the potential use of different proxies as recorders of paleo-flooding events and paleo-e
