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Hormone-sensitive lipase (HSL) is expressed and enzymatically active in beta-cells and has been proposed to be involved in the generation of the lipid-derived signal that seems to be necessary for glucose-stimulated insulin secretion. In this study, we investigated whether the expression of HSL in INS-1 cells and in rat islets is affected by exposure to high glucose concentrations. Incubation of I

The surgical repair of congenital heart defects in children with preoperative pulmonary hypertension (PH) is to varying degree associated with the occurrence of postoperative PH. The objective of this study was to follow up children with severe postoperative PH (pulmonary arterial/aortic pressure ratio ≥ 1.0) to evaluate if pulmonary arterial pressure spontaneously normalized or needed PH-targetin

The effect of a quinoline-3-carboxamide on the T-cell-dependent B-cell response was investigated in C57BL/6 mice after NP-CGG immunization. The primary serum response to the hapten was slightly inhibited by treatment with a quinoline-3-carboxamide. This inhibition was paralleled by reduced numbers of germinal center B cells and follicular T cells in the spleen up to 21 days after immunization. Als

Whether loci that influence fasting glucose (FG) and fasting insulin (FI) levels, as identified by genome-wide association studies, modify associations of diet with FG or FI is unknown. We utilized data from 15 US and European cohort studies comprising 51,289 persons without diabetes to test whether genotype and diet interact to influence FG or FI concentration. We constructed a diet score using s

Protandry, the earlier arrival of males at the breeding grounds relative to females, is common in migratory birds. However, due to difficulties in following individual birds on migration, we still lack knowledge about the spatiotemporal origin of protandry during the annual cycle, impeding our understanding of the proximate drivers of this phenomenon. Here, we use full annual cycle tracking data o

Abstract: A randomised controlled trial was performed to investigate if the short rotators affected the compliance of the capsule in osteoarthritis (OA). 68 OA patients admitted for total hip arthroplasty (THA) were randomised to have their compliance estimated during surgery with either their short rotators intact or released. Radiographic severity of OA, range of motion and pain were assessed in

Methanol is an alternative fuel offering a lower well-to-wheel CO2 emission as well as a higher efficiency, given that the fuel is derived from biomass. In addition to reduced CO2, methanol does not emit soot particles when combusted which is a great advantage when attempting to reduce NOX levels due to the effectively non-existing NOX-soot trade-off. The engine setup used was a Scania D13 engine

BACKGROUND: The immune response against discordant xenografts in the brain is incompletely understood and remains a major obstacle for future clinical applications of xenogeneic neural tissue transplants in neurodegenerative disorders. To determine the role of antibodies in the rejection process, we compared graft survival and immune reactions between immunoglobulin deficient (IgKO) and normal mic

BACKGROUND: Accumulation of myocardial triglycerides (MTG) is associated with impaired left ventricular (LV) remodelling and function in obese and diabetic subjects. The role of MTG accumulation in development of heart failure in this group of patients is unknown. Short-term studies suggest that diets that lead to weight loss could mobilize MTG, with a favourable effect on cardiac remodelling. In

A commercially available fuel, E85, a blend of ~85% ethanol and ~15% gasoline, can be a viable substitute for fossil fuels in internal combustion engines in order to achieve a reduction of the greenhouse gas (GHG) emissions. Ethanol is traditionally made of biomass, which makes it a part of the food-feed-fuel competition. New processes that reuse waste products from other industries have recently

Background Transcatheter aortic valve implantation (TAVI) is an increasingly important treatment option for patients with severe aortic stenosis. Its best implementation is debated, as few centres with high volumes are associated with better outcomes, while centralization might lead to an inferior availability of treatment for patients living far away. The aim of this study was to investigate the

OBJECTIVES: To investigate the association between low vitamin D levels (<50 nmol/L) and 10-year mortality in women aged 75 and older.DESIGN: Prospective with 15 years of follow-up.SETTING: Malmö, Sweden.PARTICIPANTS: Population-based cohort of 75-year-old women (N = 1,044).MEASUREMENTS: Serum 25-hydroxyvitamin D (25(OH)D) levels at age 75 (n = 1,011), 80 (n = 642), and 85 (n = 348) were categoriz

Curated by Claudia De la Torre and Gregorio Magnani in collaboration with the participants of the 23th edition CSAV - Artists’ Research Laboratory, the publication reflects on the experiences shared at the laboratory and on its overall theme. Through individual and collaborative contributions it investigates how sound, performance, and language may become tools in the creation of a “we” capable of

The purpose was to investigate (i) how people with psychiatric disabilities who attend day centres experience their quality of life (QoL) compared to non-attendees, (ii) differences in QoL between those who attend meeting place-oriented centres and those who attend work-oriented centres, (iii) possible correlates of QoL among day centre attendees. Ninety-three day centre attendees and 82 non-atten

Surfaktanter används inom många applikationer idag för att stabilisera eller förbättra proteiners funktion. Kartläggning av hur surfaktanter interagerar med proteiner påbörjades redan för flera årtionden sedan, men är ännu inte fullständig. Genom att förstå detta bättre kan surfaktanters användningsområden effektiviseras ytterligare och få produkter som läkemedel och rengöringsmedel som är effektiToday, proteins are used in a huge variety of industrial application ranging from detergents and pharmaceuticals to cosmetical products. Surfactants have the potential to increase solubility of poorly soluble protein, as well as hindering proteins in formulation to interact with the interface and thus protecting them from degradation. Even if the use of protein-surfactant system dates back decades

Introduction: Achieving and retaining a low background signal is essential for analytical techniques, especially for extremely accurate systems such as supercritical fluid chromatography (SFC) coupled with high-resolution mass spectrometry (HRMS) since the limits of detections are heavily dependent on the background signal. Background: A standard option to ensure a low background signal is the usa

Museum Stobaeanum included a collection of artefacts, originally labeled ”artificialia”. It consisted primarily of ethnographic objects from Asia, North and South America, Russia, Siberia, Greenland and Lapland, but also Classical antiquities, Nordic antiques, curious European works of art, as well as scientific instruments and models. Museum Stobaeanum included a comparatively small collection of

https://www.historiskamuseet.lu.se/stobaeus-project/artefacts - 2026-06-07

The purpose of this study is to investigate the extent to which the composition of the board of directors determines directors’ remuneration in Swedish listed companies. The method approach is quantitative and deductive and a multiple linear regression model analyzes the panel data. The theoretical framework consists of previous research on board compensation and theories such as agency theory, re

Aquifer storage and recovery (ASR) is a concept where water is stored in an aquifer during times when it is available, thus creating artificial groundwater, which can later be recovered by pumping when it is needed (Pyne, 1995). One ASR cycle consists of a injection, a standby and a recovery phase. The purpose of this work is to investigate the feasibility of large scale ASR systems intended for l

The aim of this thesis is to identify characteristics on how safety facilitators can improve inter-organizational learning from safety investigations. The study is a response to the fact that the Dutch Safety Board questions the learning effects of its accident investigation reports, despite that these are freely accessible on the website, which assumes that other organizations can use and learn f