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Popular Abstract in Swedish Trots ett sunt leverne med regelbunden motion och nyttig mat kan vi inte alltid förhindra risken att drabbas av vissa typer av cancer som till exempel hjärntumörer. Den vanligaste formen av elakartade hjärntumörer heter glioblastoma multiforme och är också den mest aggressiva. Symptomen varierar beroende på tumörens storlek och var i hjärnan den växer, och patienter kanGlioblastoma multiforme (GBM) is the most common and aggressive primary malignant brain tumor in adults. Despite standard treatment including surgery, radiotherapy and temozolomide (TMZ)-based chemotherapy, the prognosis for GBM patients is dismal, and there is a need for novel treatments. One possible therapeutic treatment modality presented here is immunotherapy, either alone or combined with in

OBJECTIVE: The purpose of this study was to assess the effectiveness of electronic fetal monitoring (EFM) alone and with additional ST analysis (EFM + ST) in laboring women with a singleton term pregnancy that is in cephalic presentation in the prevention of metabolic acidosis by the application of individual patient data metaanalysis. STUDY DESIGN: We conducted an individual patient data metaanal

BACKGROUND: The objective of lung transplantation (LTx) is to prolong life, but the survival benefit for patients with severe α(1)-anti-trypsin deficiency (PiZZ) and emphysema is still unclear. The aim of this study was to assess whether PiZZ patients who have undergone lung transplantation (the lung transplant group, TxG) do better than patients who have continued on the usual medical therapy (th

Objectives To estimate the associations between occupational exposure to pesticides and extrahepatic biliary tract carcinoma in men, a population-based case-control study was carried out. Methods Cases (n = 104), aged 35-70, diagnosed in 1995-1997, were sampled by active reporting systems from hospitals. Controls (n = 1,401) were a random sample of the general male population. Information on occup

Popular Abstract in Swedish Förståelse är ett komplext begrepp. Det används dagligdags utan en motsvarande strikt vetenskaplig definition. Avhandlingen strävar efter att fånga olika aspekter av detta begrepp. Tesen är att förstå handlar om att se ett mönster, i betydelsen att man kan "se" strukturen i en uppgift, en princip eller ett problem. Att se ett mönster innebär också att man uppmärksammar The thesis proposes that understanding is a matter of experiencing a pattern. To experience a pattern involves seeing how a task, principle, or problem space is structured; to attend to the relevant information; and to be able to use that information as it relates to the knowledge domain at hand. The every day concept of understanding, which is a term used in many ways is discussed and it is explo

We present the results of 3D high-resolution calculations of the last inspiral stages and the final coalescence of neutron star binary systems. The equations of hydrodynamics are solved using the smoothed particle hydrodynamics method with up to 106 particles. Using Newtonian gravity, but adding the forces emerging from the emission of gravitational waves, we focus on the impact of microphysics on

Popular Abstract in Swedish När främmande fettlösliga ämnen som miljögifter (ex. PCB och dioxin) hamnar inuti kroppen bearbetas de ofta av det så kallade biotransformations-systemet. När inte levern och njurarna direkt kan utsöndra de främmande molekylerna får enzymer ändra de oönskade ämnenas kemiska sammansättning. Detta görs genom att ändra molekylernas kemiska egenskaper så att de blir vattenlIn vertebrates, studies of the aryl hydrocarbon receptor (AhR) have been of particular interest due to its direct involvement in the toxic effects exerted by several environmental pollutants, such as PCB and dioxin. After binding to the toxic molecule, this receptor initiates transcription of several genes that are part of the biotransformation battery but most notably the cytochrome P450 (CYP) ge

Popular Abstract in Swedish Protontransport är en fundamental process som finns i många naturliga system, liksom i många tekniska applikationer, såsom bränsleceller, smarta fönster och olika typer av sensorer. Bränslecellsteknologi anses vara miljövänlig eftersom bränsleceller inte begränsas av Carnot-cykeln och omvandlar effektivt kemisk energi till elektrisk energi som sedan kan användas till atProton transport is a fundamental process that can be found in many systems in nature, as well as in technical devices, such as fuel cells, electrochromic devices and various types of sensors. Fuel cell technology is considered as environmentally friendly because fuel cells are not limited by the Carnot cycle, and efficiently converts chemical energy into electrical energy which can be used for po

Popular Abstract in Swedish Proteinkinas C (PKC) är en familj enzymer (protein som påskyndar cellulära förlopp) bestående av åtminstone 10 medlemmar (isoformer) vilka är involverade i ett flertal cellulära processer. Varje isoform är namngiven med en grekisk bokstav och beroende på olika egenskaper hos enzymerna kan PKC familjen delas in i tre undergrupper, de klassiska (α, βΙ, βΙΙ och γ), de nya Protein kinase C (PKC) is a family of serine/threonine kinases subgrouped into classical (α, βI, βII, γ), novel (δ, ε, η, θ) and atypical (ζ, ι/λ) isoforms. PKC can be activated by phorbol esters, and prolonged treatment of neuroblastoma cells has been shown to induce neuronal differentiation with neurite outgrowth and increased expression of neuronal genes. Here we show that a classical PKCβ isof

Abstract in Norwegian Afhandlingens emne er måling af effekt af McKenzie behandlingsmetoden til patienter med uspecifik lænderygbesvær og udvikling af et diagnostisk klassifikationssystem til brug i primærsektoren. McKenzie metoden er en af de mest anvendte af fysioterapeuter i en række vestlige lande til undersøgelse og behandling af patienter med rygbesvær. Delarbejde I er den første publiceredeThe aims of this thesis were to investigate the effects of the Mc-Kenzie method of mechanical diagnosis and therapy compared with that of intensive dynamic strengthening training for patients with non-specific low back pain (NLBP), and to develop a clinical diagnostic classification system for use in primary care. The McKenzie method is one of the most common methods for examination and treatment

Do women with Turner karyotype have increased mortality and morbidity in the years after childbirth? No mortality occurred during pregnancy and follow-up in women with Turner karyotype, but a higher rate of circulatory and endocrine diseases and a high risk of aortic aneurysm were confirmed. Pregnancies in women with Turner karyotype are high-risk pregnancies with an increased risk of maternal mor

In the past two decades, the eddy covariance technique has been used for an increasing number of methane flux studies at an ecosystem scale. Previously, most of these studies used a closed path setup with a tunable diode laser spectrometer (TDL). Although this method worked well, the TDL has to be calibrated regularly and cooled with liquid nitrogen or a cryogenic system, which limits its use in r

BACKGROUND:: Childhood immunology has been suggested to play a role in development of inflammatory bowel disease (IBD) based on the studies of childhood vaccinations, infections, and treatment with antibiotics. Bacille Calmette-Guérin (BCG) and smallpox vaccinations were gradually phased-out in Denmark for children born between 1965 and 1976, hence allowing the study of subsequent risk of Crohn's

Blood vessels and adjacent cells form perivascular stem cell niches in adult tissues. In this perivascular niche, a stem cell with mesenchymal characteristics was recently identified in some adult somatic tissues. These cells are pericytes that line the microvasculature, express mesenchymal markers and differentiate into mesodermal lineages but might even have the capacity to generate tissue-speci

Popular Abstract in Swedish Mögel i byggnader är ett vanligt problem som kan orsaka en dålig innemiljö och påverka hälsan hos de personer som vistas i byggnaden. Kostnaderna för att åtgärda problemen kan vara omfattande. Att redan vid planeringsstadiet av en byggnad ta hänsyn till risker för mögelväxt kan leda till minskat antal mögelskador i framtiden och ett mer hållbart byggande. Mögelväxt är The susceptibility to mould growth varies between building materials. The factors that most affect mould growth, the relative humidity (RH) and temperature also vary in different parts of buildings. One way of preventing the growth of mould in buildings is therefore to choose building materials that can withstand the expected conditions. It is thus crucial that data are available to allow the corr

Introduction: Development of industrial yeast strains with high tolerance towards the inhibitors released during biomass pretreatment is critical for bioethanol production. Combining this trait with increased thermotolerance would result in a more efficient production via Simultaneous Saccharification and Fermentation (SSF) as well as reduced cooling costs. The aim of the present work was to devel

The decline of one farmland bird, the migratory European starling, has been attributed to both agricultural intensification and farmland abandonment and to factors operating both during the winter and during the breeding season. We analysed population data from thirty-three Swedish nestbox colonies over more than two decades to determine if the national decline was caused by a common factor affect

Hybridization is observed frequently in birds, but often it is not known whether the hybrids are fertile and if backcrossing occurs. The breeding ranges of the great reed warbler (Acrocephalus arundinaceus) and the clamorous reed warbler (A. stentoreus) overlap in southern Kazakhstan and a previous study has documented hybridization in a sympatric population. In the present study, we first present

Pictures and other iconic media are used extensively in psychological experiments on nonhuman primate perception, categorisation, etc. They are also used in everyday interaction with primates, and as pure entertainment. But in what ways do primates understand iconic artefacts? What implications do these different ways have for the conclusions we can draw from those studies on perception and catego

This dissertation deals with conversational practices through which interactants manage issues of intersubjectivity, i.e. mutual understanding for all practical purposes. Intersubjectivity is understood in a procedural sense, and as built into the infrastructure of interaction, where each next action embodies aspects of how the previous action was understood. This understanding can be inspected by