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Historical data are valuable resources for providing insights into general patterns in the past. However, these data often inform us at the macro-level of analysis but not about the role of individuals’ behaviours in the emergence of long-term patterns. Therefore, it is difficult to infer ‘how’ and ‘why’ certain patterns emerged in the past. Historians use various methods to draw hypotheses about
RATIONALE: A previous short-term study showed that a computer-based training in eating and nutrition increased the probability for hospital inpatients at undernutrition (UN) risk to receive nutritional treatment and care without increasing overtreatment (providing nutritional treatment to those not at UN risk). The aim of this study was to investigate if a computer-based training in eating and nut
Whether free returns create economic value for online retailers is a question of increasing importance. Using order-level data from an online fashion retailer in Sweden, we investigate the introduction of free returns for customers in Denmark starting November 1, 2017, but not for customers in Sweden, Norway, Finland, France, Germany, and the rest of Europe (the control group). Using difference-in
Background: Patients with bladder pain syndrome experience debilitating pain and extreme frequency of urination. Numerous therapeutic approaches have been tested, but as the molecular basis of disease has remained unclear, specific therapies are not available. Objective: Recently, a systematic gene deletion strategy identified interleukin-1 (IL-1) hyperactivation as a cause of severe cystitis in a
Business models direct a firm’s activity to move in coherence with the objectives of the business. Current literature suggests business models can act as vital forces to facilitate sustain-ability transitions and highlights the urgent research call to understand the role of business model innovations in stimulating sustainability transitions. This paper addresses this research need by investigatin
Despite the average 5-year survival rate exceeding 85%, childhood cancer is still the most common cause of disease-related death among children in Sweden. A cancer diagnosis is profoundly traumatic not only for children themselves, but also for the entire family, particularly the primary caregivers, their parents. This project aimed to investigate the extent to which a childhood cancer diagnosis a
Despite being subject to a multitude of investigations, the effect of carrier particle size on the performance of adhesive mixtures for inhalation is still not well understood. This study, involving three differently sized lactose carriers, all with the regular ‘tomahawk’ particle shape, aims to provide fundamental insight into this topic. Fine particle fraction (FPF) data for binary formulations
The capacity for birds to adjust their breeding time to variation in spring temperature via plasticity is crucial for insectivorous passerines in temperate areas, particularly in a context of climate disruptions. Recent studies suggested that phenological plasticity varies in response to environmental change via urbanization. We investigated the effects of urbanization on laying date, its phenotyp
Background: Colophony and its derivatives are common allergens. Contact dermatitis from colophony-containing adhesive tapes for blister prevention has previously been reported among Swedish conscripts. Objectives: To present the investigation of suspected allergic contact dermatitis among Norwegian military personnel exposed to medical adhesive tapes during service. Patients/Materials/Methods: Fou
Only 40% of the total CO2 emitted by human activities and natural sources remain in the atmosphere, since the rest is taken up by plants and oceans. In particular temperate and boreal forests are usually significant sinks of carbon, even if they are very susceptible ecosystems and they might turn into sources in consequence of the predicted temperature increase. That is one of the reasons why a ne
Regular, vigorous physical activity can have a significant impact on cardiac function, leading to cardiac morphological alterations that may be challenging to distinguish from pathological changes. Therefore, new screening methods are needed to accurately differentiate between adaptive changes and pathological alterations in athletes. Vortex formation time (VFT) is an emerging method that shows po
Science is a risky business, and risk-taking is a critical disposition for scientists. This study uses a combination of survey and bibliometric data to measure the degree of individual scientists' risk-taking and investigate its determinants. In particular, we focus on academic training as a critical arena for the socialization of risk-taking and examine whether and how risk-taking is transmitted
Telomere length (TL) early in life often shows high heritability and may predict telomere shortening later in life and life expectancy. Yet, there is limited data about what influences TL and TL change at early developmental stages. It is debated whether early-life TL is determined at conception or shaped by early environmental conditions. Here, we investigate whether TL and telomere shortening ar
Research on birds suggests that extreme weather events during development may have long-lasting consequences on form and function. The underlying cellular mechanisms mediating such phenotypic effects are poorly studied. We raised Japanese quail in warm (30°C) or cold (10°C) temperatures from hatching until adulthood and then measured mitochondrial metabolism in intact blood cells at representative
High-pressure homogenizers (HPHs) are used extensively in food-, pharma-, and biotech processing. Erosion wear is a serious concern leading to high maintenance costs and downtime. Despite this, very little is known about how operating conditions and HPH design influence wear. Guidelines for optimizing design and operation are in great need. This contribution develops a relatively simple CFD-based
Minimal Kitaev chains, composed of two quantum dots connected via a superconductor, have emerged as an attractive platform to realize Majorana bound states (MBSs). These excitations exist when the ground state is degenerate. The additional requirement of isolating the MBS wave functions further restricts the parameter space to discrete sweet spots. While scaling up to Kitaev chains with more than
Memory decline is a central cognitive symptom in Parkinson’s Disease (PD). While task-fMRI studies link hippocampal activity (AHA) to poorer memory and olfactory performance, this relationship during rest remains understudied. The objectives of this study are to examine differences in resting-state hippocampal networks, explore the occurrence of reduced AHA within these networks, and investigate i
BACKGROUND: Cytoreductive surgery with intraperitoneal chemotherapy has emerged as a new standard approach for peritoneal surface disease. This study investigated the learning curve of this combined modality treatment at a single institute.METHODS: Variables analysed over three consecutive treatment periods (1996-1998, 1999-2002 and 2003-2006) included number of abdominal regions affected, Simplif
