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BACKGROUND: Fast-track referral is an increasingly used method for diagnostic evaluation of patients suspected of having cancer. This approach is challenging and not used as often for patients with only nonspecific symptoms. In order to expedite the diagnostics for these patients, we established Sweden's first Diagnostic Center (DC) focusing on outcomes related to diagnoses and diagnostic time int
Diabetes affects the morphology and plasticity of the hippocampus, and leads to learning and memory deficits. Caffeine has been proposed to prevent memory impairment upon multiple chronic disorders with neurological involvement. We tested whether long-term caffeine consumption prevents type 2 diabetes (T2D)-induced spatial memory impairment and hippocampal alterations, including synaptic degenerat
Objective: Subjective cognitive decline (SCD) is associated with an increased risk of Alzheimer's Disease (AD). Early disease processes, such as amyloid-β aggregation measured with quantitative PET, may help to explain the phenotype of SCD. The aim of this study was to investigate whether quantitative amyloid-β load is associated with both
Objective: Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is associated with life-threatening bleeding. This systematic review of postnatal management of FNAIT examined transfusion of human platelet antigen (HPA) selected or unselected platelets, and/or IVIg on platelet increments, hemorrhage and mortality. Study design: MEDLINE, EM
Cognitive linguistic and semiotic accounts of metaphors have often discussed the complex phenomenon of metaphor in various ways, often addressing factors such as universality and conventionality, context-sensitivity, cross-cultural variation and creativity, deliberateness and “multimodality”. However, in most cases, such factors are investigated in isolation (cf. Gibbs 2017). Therefore, we propose
The chemical bonding in a series of nickel mixed oxides, namely Li2NiO2, Na2NiO2, tetragonal and orthorhombic La2NiO4 for Ni(II), LiNiO2, NaNiO2, LaNiO3 for Ni(III), BaNiO3 for Ni(IV) and LaNiO2, 'LaSrNiO3' for Ni(I), is investigated from the results of electronic structure calculations, including both band structure and local properties, i.e. atomic charges, covalent bond orders and atomic valenc
AIMS: Failure of healing is a well-known problem after repair of the rotator cuff. This study aimed to investigate if early repair of trauma-related full-thickness rotator cuff tears (FTRCTs) could prevent this failure. PATIENTS AND METHODS: In this prospective trial, 62 consecutive patients (14 women (23%), 48 men (77%); median age 61 years (interquartile range (IQR) 54 to 65)) with trauma-relate
The current study compares controlled acceptability judgments for Swedish relative clause extractions to extractions from that-clauses and extractions from non-restrictive relative clauses. It also compares each structure in both extracted and non-extracted form. The reported possibility of relative clause extraction in Swedish (and the other Mainland Scandinavian languages) has long presented a c
Background: Cerebrovascular disease (CVD) and amyloid-β (Aβ) often coexist, but their influence on neurodegeneration and cognition in predementia stages remains unclear. We investigated the association between CVD and Aβ on neurodegenerative markers and cognition in patients without dementia. Methods: We included 271 memory clinic patients with subjective or objective cognitive deficits but withou
This experimental study adapts a usage-based perspective on L2 acquisition (Bybee 2008; Ellis 2008) and focuses on the production of French subject-verb (SV) agreement in number (singular vs. plural). Previous studies show that the acquisition of this agreement is a long and gradual process in L2 French (Bartning & Schlyter 2004; Prévost 2009; Michot 2015). This study examines the influence of
In the many published theories on the retention in reversed-phase chromatography (RPC), the focus is generally on the effect of the concentration of the mobile phase modulator(s), although temperature is known to have a significant influence both on the retention and on the selectivity between the adsorbates. The aim of this study was to investigate and model the combined effects of the temperatur
It has long been thought that respiratory infections are the direct result of acquisition of pathogenic viruses or bacteria, followed by their overgrowth, dissemination, and in some instances tissue invasion. In the last decades, it has become apparent that in contrast to this classical view, the majority of microorganisms associated with respiratory infections and inflammation are actually common
Swedish asthma guidelines recommend treating asthma with the lowest effective dose possible. These recommendations are both hard to follow and seldom considered enough in asthma care today. As an example, combination therapy with inhaled corticosteroids (ICS) and long acting beta agonists (LABA) should only be considered if asthma control is not achieved with low to medium dose ICS daily. However,
This article sets out to identify a culture of advocacy that has come to characterise Swedish civil society, formed around a long-standing tradition of close and cordial relations between civil society organisations, popular movements, and state and government officials. We argue that Swedish civil society organisations (CSOs) have been allowed to voice critique against public actors and policies
This thesis makes a contribution to the areas of deregulation, competition and consumer choice. It consists of three self-contained papers. All the research questions are examined in the context of the Swedish motor vehicle inspection market.The first paper, Competition Makes Inspectors More Lenient: Evidence from the Motor Vehicle Inspection Market, investigates whether increased competition moti
Background and aim: Transport planning faces new demands for a dialogue with users. Transport planners no longer just build roads; nowadays they also must listen to users, whose wishes are meant to have an impact on the design and maintenance of the road transport system. Yet how can we know what users really want? This article sets out to analyze the methods with which transport planners gather i
Background: Current EU directives demand increased use of renewable fuels in the transportation sector but restrict governmental support for production of biofuels produced from crops. The use of intercropped lucerne and wheat may comply with the directives. In the current study, the combination of ensiled lucerne (Medicago sativa L.) and wheat straw as substrate for hydrogen and methane productio
