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Human pluripotent stem cells (hPSCs) can undergo unlimited self-renewal and have the capacity to differentiate into all somatic cell types, and are therefore an ideal source for the generation of cells and tissues for research and therapy. To realize this potential, defined cell culture systems that allow expansion of hPSCs and subsequent controlled differentiation, ideally in an implantable three

Introduction Tourette syndrome and chronic tic disorder are common, disabling childhood-onset conditions. Guidelines recommend that behavioural therapy should be offered as first-line treatment for children with tics. However, there are very few trained behaviour therapists for tics and many patients cannot access appropriate care. This trial investigates whether an internet-delivered intervention

Most creative professionals develop and refine their talents by learning from others. In most empirical settings, estimating how this learning process fosters quality is challenging. This paper explores the transmission of quality among music composers over more than seven centuries. How does a composer’s quality influence the quality of the composers they teach? Using a unique dataset of 17,433 c

Newborn male infants have higher morbidity and mortality than female infants. Male fetal gender is associated with an overall increased risk of preterm birth and complications related to pregnancy are overrepresented in women carrying male fetuses. Several studies have shown that being newborn and of male gender are independent risk factors for adverse outcome. Even though experimental data from n

It is expected that, in the future, gas turbines will be operated on gaseous fuels currently unutilized. The ability to predict the range of feasible fuels, and the extent to which existing turbines must be modified to accommodate these fuels, rests on the nature of these fuels in the combustion environment. Understanding the combustion behavior is aided by investigation of syngases of similar com

We obtained a long-time-storage mechanism for spectral features in thulium ions doped into YAG by applying a magnetic field that splits the electronic ground state. We show experimentally that the storage time can be more than 30 s, which is 3 orders of magnitude longer than that of the metastable state that normally is used for information storage in this material. Level splitting and storage lif

A methacholine or a histamine test is often used to quantitate bronchial responsiveness, in studies investigating the influence of various inhaled stimuli on the responsiveness and composition of bronchoalveolar lavage (BAL) fluid. Histamine has been shown to evoke an inflammatory cell response in BAL fluid. In order to test the influence of the methacholine test on the cellular composition of BAL

The unfolding of choral history and the development of pedagogical ideas largely depend on a combination of social and musical factors. This is what makes choral research both interesting and challenging. Choral representation of societal change does emerge at different historical periods in the European countries – for example in connection with the French Revolution, in Sweden after World War II

Do certain humans and animals have greater value than other humans and animals? The question will be discussed using some examples from pre-Christian burial practices and other depositions of human and animal bones in Scandinavia. During the pre-Christian period it seems that certain humans and certain animals were buried in graves made for the purpose, while other humans and animals were deposite

The interest in economic evaluation of alternative strategies for haemophilia treatment has increased through the years. Few studies have actually been undertaken, however, and most of them have been simple cost-minimization or cost-effectiveness analyses. From the perspective of the binational project 'Treatment strategies for severe haemophilia - prophylaxis vs. on-demand', the present paper dis

Background/Objectives: Worldwide, men experience a higher incidence of pancreatic cancer (PC) than women. Methods: To increase understanding of the underlying reasons for this sex-related difference, we analysed general and sex-related risk factors for PC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (women/men No. = 293,682/136,728; 717/577 PC-cases). Results:

Experimental Evolution: From hermaphrodite to two sexes! When one hears the word evolution most of us think of Charles Darwin and his theory of natural selection. He once said, ”It is not the strongest of species that survive, nor the most intelligent, but the one most responsive to change”. We will get back to that, but a very important thing here is that the timeframe he is talking about is mil

För tidigt födda och sjuka barn hamnar på neonatal avdelning där de ofta behandlas med kombinationer av flera olika intravenösa läkemedel. Att kombinera intravenösa läkemedel innebär dock en risk för inkompatibilitet i form av fällningar och subvisuella partiklar, vilket kan riskera i livshotande tillstånd så som till exempel funktionssvikt i flera organ samt allvarliga hjärt- och kärlproblem. SoThere is a lack of data concerning compatibility between intravenously administered drugs, especially for doses administered in neonatal care. Co-administrating drugs or other substances used in hospital care, for instance parenteral nutrition that are incompatible with each other can, in worst case scenarios, lead to fatal outcomes. It is not only important to study drug incompatibility at differ

Following trends in local and global environments, it is obvious that many companies are faced with difficulties to survive in this competitive environment. Business Model Innovation (BMI) is the key to the firm’s long-term success. The case study of BTC d.d., has been made to give an example how firms should be aware of their weaknesses and strengths in order to constantly innovate their business

We investigate investor heterogeneity between private, institutional, commercial, government and foreign investor in the Swedish market. OLS-estimation using dividend yield and term spread as regressors reveal no clear results. VAR-analysis to investigate lead-follow relationships between investor groups indicate that foreign follows private and commercial investors, though the result is problemat

Abstract The long-term aim of this project was to develop synbiotic drinks presenting food supplements with beneficial effects on human health. A synbiotic consists of a combination of probiotic bacteria and one or more prebiotics. For the part of the project that was covered by this Master thesis, a probiotic strain, Lactobacillus plantarum F44 and a prebiotic galactooligosaccharide (GOS) were t

Background: Plasma phospholipid fatty acids have been correlated with food intakes in populations with homogeneous dietary patterns. However, few data are available on populations with heterogeneous dietary patterns. Objective: The objective was to investigate whether plasma phospholipid fatty acids are suitable biomarkers of dietary intakes across populations involved in a large European multicen

The depletion of oil reserves and the increasingly stringent European Union regulation of air pollution have forced researchers and manufacturers to search for cleaner and sustainable substitutes to petroleum‐based transportation fuels. Biofuels like small aliphatic alcohols are of increasing interest as alternatives to fossil fuels, as they offer long‐term fuel‐source regenerability. As major adv