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Detection and removal sentinel lymph nodes (SLN) is important in the diagnosis and treatment of breast cancer and malignant melanoma. The SLN is the first regional lymph node draining the cancer tumor and if the cancer has spread it is most likely to find cancer cells in the SLN. In this study we have been able to detect multimodal superparamagnetic iron oxide nanoparticles (SPIO-NP) in rat SLNs i
The impact of different drying techniques and storage conditions on the formation of carboxymethyl lysine (CML) as an advanced glycation end product (AGE) was investigated in various pilot-scale produced skim milk powders (SMP). CML, an indicator of advanced stages of the Maillard reaction, was analyzed by isotope dilution ESI-LC-MS/MS after drying and at intervals during storage for 200 days. The
The MAX IV facility in Lund, Sweden, consists of two storage rings for production of synchrotron radiation, and a full-energy LINAC for top-up injections. The LINAC also delivers short high-intensity electron bunches to a short pulse facility. MAX IV was inaugurated in June 2016, and the larger 3 GeV ring has been delivering light to users since November 2016. In this thesis, the design and implem
PurposeEmpirical studies show that 96% of the city logistics projects failed to become permanent, mainly due to the lack of sustainable business models (Quak et al., 2014; Malhene et al., 2012). Accordingly, it was concluded that the need of business model specifically designed for city logistics is high (Benjelloun, 2010). However, researchers have yet to describe the components and their interre
The aim of this study was to identify molecules that trigger complement activation in rheumatic joints. C4d, the final cleavage product of C4 activation, is found in the diseased joint and can bind covalently to complement-activating molecules. By using a highly specific Ab against a cleavage neoepitope in C4d, several molecules that were specifically bound to C4d were identified from pooled synov
Objective: To determine if blood neurofilament light chain (NfL) protein can discriminate between Parkinson disease (PD) and atypical parkinsonian disorders (APD) with equally high diagnostic accuracy as CSF NfL, and can therefore improve the diagnostic workup of parkinsonian disorders. Methods: The study included 3 independent prospective cohorts: the Lund (n = 278) and London (n = 117) cohorts,
In a joint research project – Human Factors in Air Navigation Services, HUFA – between the Swedish Civil Aviation Administration and Lund University the focus is on human and organizational factors and safety in air traffic control. The Swedish Air Navigation Services (ANS) are undergoing major organizational changes in order to adapt to changing demands on efficiency and technical development in
The size distributions and hygroscopic growth spectra of aerosol particles were measured during the GCE cloud experiment at Great Dun Fell in the Pennine Hills in northern England. Hygroscopic growth is defined as the particle diameter at 90% RH divided by the particle diameter at 10% RH. The fraction of the aerosol particles scavenged by cloud droplets as a function of particle size was also meas
PURPOSE: We have recently identified homeostatic alterations in the circulating T cells of patients with age-related macular degeneration (AMD). In cultures of retinal pigment epithelial cells, we have demonstrated that T-cell-derived cytokines induced the upregulation of complement, chemokines and other proteins implicated in AMD pathogenesis. The purpose of this study was to test whether increas
Context. In the era of massive spectroscopy surveys, automated stellar parameter pipelines and their validation are extremely important for an efficient scientific exploitation of the spectra. Aims. We undertake a critical and comprehensive comparison of the radial velocities and the main stellar atmosphere parameters for stars in common between the latest data releases from the Apache Point Obser
The technique of chemical tagging uses the elemental abundances of stellar atmospheres to 'reconstruct' chemically homogeneous star clusters that have long since dispersed. The GALAH spectroscopic survey - which aims to observe one million stars using the Anglo- Australian Telescope - allows us to measure up to 30 elements or dimensions in the stellar chemical abundance space, many of which are no
There is limited research on indoor air quality in the Middle East. In this study, concentrations and size distributions of indoor particles were measured in eight Jordanian dwellings during the winter and summer. Supplemental measurements of selected gaseous pollutants were also conducted. Indoor cooking, heating via the combustion of natural gas and kerosene, and tobacco/shisha smoking were asso
Soil erosion by water represents a serious threat to the natural and human environment in Mediterranean countries, including Lebanon, which represents a good case study. This research deals with how to use Geographic Information Systems (GIS), remote sensing, and, more specifically, structural classification techniques and decision-tree modeling to map erosion risks and design priority management
Aim: The aim of this study was to evaluate the therapeutic efficacy and safety profile of orally administered low-dose ketamine for procedural pain management in pediatric cancer patients undergoing lumbar puncture (LP) in a resource-limited hospital setting. Methods: Patients between 4 and 15 years of age, with leukemia, undergoing LP were asked to participate. The study was designed as a two-a
This report presents the sixth version of the European Grassland Butterfly Indicator, one of the EU biodiversity indicators of the European Environment Agency.The indicator is based on more than 9200 transects in national Butterfly Monitoring Schemes covering 22 countries across Europe, most of them active in the European Union. In 2015, counts were made in more than 4500 transects.Butterflies rep
Background: FLASH radiotherapy (RT) is a novel method for delivering ionizingradiation, which has been shown in preclinical studies to have a normal tissuesparing effect and to maintain anticancer efficacy as compared to conventionalRT. Treatment of head and neck tumors with conventional RT is commonlyassociated with severe toxicity, hence the normal tissue sparing effect of FLASHRT potentially ma
An efficient numerical method for nearly simultaneous computation of all conditional moments needed for quasi maximum likelihood estimation of parameters in discretely observed stochastic differential equations is presented. The method is not restricted to any particular dynamics of the stochastic differential equation and is virtually insensitive to the sampling interval. The key contribution is
The present study was designed to analyse whether continuous overexpression of glial cell line-derived neurotrophic factor (GDNF) in the striatum by a recombinant lentiviral vector can provide improved cell survival and additional long-term functional benefits after transplantation of fetal ventral mesencephalic cells in Parkinsonian rats. A four-site intrastriatal 6-hydroxydopamine lesion resulte
