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Background: Coronary artery remodelling and vasospasm is a complication of acute myocardial ischemia and reperfusion. The underlying mechanisms are complex, but the vasoconstrictor peptide endothelin-1 is suggested to have an important role. This study aimed to determine whether the expression of endothelin-1 and its receptors are regulated in the myocardium and in coronary arteries after experime
At the end of 2014, a Major Baltic Inflow (MBI) brought oxygenated, salty water into the Baltic proper and reached the long-term anoxic Eastern Gotland Basin (EGB) by March 2015. In July 2015, we measured benthic fluxes of phosphorus (P), nitrogen (N) and silicon (Si) nutrients and dissolved inorganic carbon (DIC) in situ using an autonomous benthic lander at deep sites (170-210 m) in the EGB, whe
Voltage-gated sodium channels (Nav1.1-Nav1.9) are responsible for the initiation and propagation of action potentials in neurons, controlling firing patterns, synaptic transmission and plasticity of the brain circuit. Yet, it is the protein-protein interactions of the macromolecular complex that exert diverse modulatory actions on the channel, dictating its ultimate functional outcome. Despite the
Background Late blight (caused by Phytophthora infestans) is a devastating potato disease that has been found to occur earlier in the season over the last decades in Fennoscandia. Up until now the reasons for this change have not been investigated. Possible explanations for this change are climate alterations, changes in potato production or changes in pathogen biology, such as increased fitness o
Aims: The nuclear proliferation marker Ki67 assayed by immunohistochemistry has multiple potential uses in breast cancer, but an unacceptable level of interlaboratory variability has hampered its clinical utility. The International Ki67 in Breast Cancer Working Group has undertaken a systematic programme to determine whether Ki67 measurement can be analytically validated and standardised among lab
The novel method of modification of polyethersulfone (PES) ultrafiltration membranes is proposed. This method involves the use of aqueous solutions of polyacrylic acid (PAA) of different molecular weights (Mn=5.1×103 g·mol–1, Mn=490×103 g·mol–1) as a coagulant in non-solvent induced phase inversion process (NIPS). Addition of PAA (0.05–1.5 wt%) to the coagulation bath leads to marked changes in pe
BackgroundDementia is a syndrome, with a wide range of symptoms. It is important to have a timely diagnosis during the disease course to reduce the risk of medication errors, enable future care planning for the patient and their relatives thereby optimizing quality of life (QoL). For this reason, it is important to avoid a diagnosis of dementia not otherwise specified (DNOS) and instead obtain a d
Objective: The association between knee injury and knee osteoarthritis (OA) is understudied relative to its importance, particularly in younger populations. This study was undertaken to examine the association of knee injury with radiographic features of knee OA in military officers, who have a physically demanding profession and high rates of knee injury. Methods: Participants were recruited in 2
BackgroundEarly detection of diabetes and hypertension is helpful to prevent and/or delay the onset of these diseases through proper interventions. Therefore, it is a prerequisite to know the prevalence of prediabetes and prehypertension and the factors associated with these conditions but people from developing countries including Bangladesh often remain undiagnosed and unaware of these condition
Objective Longitudinal clinical registry-infrastructures such as Anti-Rheumatic Therapies in Sweden (ARTIS) allow simultaneous comparison of the safety of individual immunomodulatory drugs used in clinical practice, with consistent definitions of treatment cohorts, follow-up and outcomes. Our objective was to assess and compare incidence rates of key safety outcomes for individual targeted synthet
Background: Choice theory stems from psychological concepts like self-concept, successful identity, and quality of the world. The theory encourages adolescents to accept the responsibility for their choices on the one hand and predict the effect of such decisions on their lives on the other hand. The present study aimed to investigate the effectiveness of choice theory-based group training in inte
The purpose of this study is to address the main reasons that limit Jordanian women from undertaking expatriation, based on the assumption that Arab women’s opportunities for international engagement may be compromised by local cultural and institutional issues. Design/methodology/approach: A cross-sectoral survey with 60 Jordanian expatriates (30 women and 20 men) located in EU countries and the
Purpose: Cold air exposure is associated with increased respiratory morbidity and mortality. Repeated inhalation of cold and dry air is considered the cause of the high prevalence of asthma among winter endurance athletes. This study assessed whether a heat- and moisture-exchanging breathing device (HME) attenuates airway responses to high-intensity exercise in sub-zero temperatures among healthy
The European daylight standard EN 17037 was first introduced in 2018 with the aim of encouraging building designers to evaluate and ensure adequate daylight provision in buildings. However, experience has shown that the standard’s criteria are generally perceived to be too challenging to achieve. Therefore, to suggest a more balanced threshold, this master’s thesis aims to investigate compliance r
Digitalization has in recent years transformed the music industry and how people consume music. Simultaneously, the social media app TikTok has emerged as a major player in marketing, using its unique algorithmic structure and user-generated content to become a powerful marketing tool for musicians and record labels alike. Therefore, this paper investigates the effect of TikTok on music consumptio
In multi-user multiple input multiple output (MU-MIMO), the complexity of the base-station scheduler has increased further compared to single-user multiple input multiple output (SU-MIMO). The scheduler must understand if several users can be spatially multiplexed in the same time-frequency resource. One way to spatially separate users is through beamforming with sufficiently many antennas. In thi
In the fifth generation of mobile communication, 5G, frequencies above 30 GHz, so-called millimeter-wave (mm-wave) frequencies are expected to play a prominent role. For the synthesis of these frequencies, the all-digital phase locked loop (ADPLL) has recently gained much attention. A core component of the ADPLL is the digitally controlled oscillator (DCO), an oscillator that tunes the frequency d
Background The cerebrospinal fluid (CSF) is involved in several diseases and patho- physiological states, such as Alzheimer’s disease and hydrocephalus. Previous studies CSF dynamics in the brain show that the flow of the CSF depends on cardiac pulsation, time of day and respiration. Methods In this thesis, the validity of using real time phase contrast MRI in order to study CSF flow is evaluated
