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The production of health economic evaluations of pharmaceuticals is a global, multibillion dollar industry. Despite this fact, little is known about what happens after a health economic evaluation has been produced. Will it be used at all, and if so, how? Who uses economic evaluations and for what purposes? Are there differences in the use patterns between decision makers at macro, meso and micro
A previous study compared two student groups that played a mathematics game based on a teachable agent. One group played with, and the other without, the inclusion of a social conversation module: a chat between the student and the teachable agent. Results were that students who used the game with the chat included had a more positive experience of the game and learned more in the sense of teachin
The flexibility of implantable neural probes has increased during the last 10 years, starting with stiff materials such as silicone to more flexible materials like polyimide. We have developed a novel polymer based on Off-Stoichiometry Thiol-Enes + Epoxy (OSTE+, consisting of a thiol, two allyls, an epoxy resin and two initiators), which is up to 100 times more flexible than polyimide. Since a fle
Use of utilities, such as steam and cooling water, is very common at industrial sites. Utilities are often shared between several production areas, and a disturbance in the supply of a utility is therefore likely to affect a large part of the production site, and cause great loss of revenue. In order to minimize the loss of revenue due to disturbances in utilities, the optimal supply of utilities
Recent papers have proposed to design scheduling algorithms entirely as discrete-time controllers, i.e., to refrain from preserving the already installed scheduler, and replace it completely. At the cost of some system re-design impact, this new approach has been proved to yield significant advantages in terms of code size and simplicity, and above all to open the way to a system-theoretical analy
Ammonia detection is highly relevant for combustion in boilers and furnaces since NH3 is able to suppress nitric oxide levels by catalytic as well as non-catalytic reduction. The mixing of ammonia with flue gases is an important parameter to obtain efficient non-catalytic reduction. In this paper picosecond DIAL was used for range-resolved, single ended, NH3 detection, utilizing a tunable picoseco
We describe the characterization of the hydrodynamic properties of anisotropic magnetic nanoparticles using a combination of transmission electron microscopy (TEM) and dynamic as well as depolarized dynamic light scattering (DLS/DDLS). The particles used are nearly monodisperse hematite spindles with an average length of 280 nm and a minor axis of 57 nm, coated with a layer of silica of variable t
Recent findings show that human fibroblasts can be directly programmed into functional neurons without passing via a proliferative stem cell intermediate. These findings open up the possibility of generating subtype-specific neurons of human origin for therapeutic use from fetal cell, from patients themselves, or from matched donors. In this study, we present an improved system for direct neural c
The family of proteins called galectins, are a group of carbohydrate-binding proteins. This allows them to take part in cell signalling by binding to glycoproteins on cell surfaces. Galectin-9 has been identified as a TIM3 ligand. TIM3 is a protein found on T-cells, which are used by the immune system to destroy for example cancer cells. When galectin-9 binds TIM3 it starts a reaction chain which
Cardiotography, CTG, is a monitoring method that is commonly used during childbirth. The method measures the fetal heart rate, FHR, alongside the uterine contractions, TOCO. Clinicians use this tool to evaluate the health of the infant, and to observe changes which might imply hypoxia, lack of oxygen supply, for the fetus. However, abnormalities in the CTG are often non-specific, making the interp
This paper seeks to express the chemical potential for proteins on a surface in terms of number surface densitiy. Generalized Van der Waals (GVdW) theory and Virial hard disk theory are explored and fitted to experimental data by varying the hard disk radius. Additionnally Metropolis Monte Carlo simulations are used to simulate the interactions between proteins. Simulations are done on freely rot
In this paper two different concepts are analyzed: information disorder and cooperation. Psychological warfare has become an increasingly pressing problem during the past few years. Several different notions are being used within the concept, including disinformation, misleading information and information disorder. Problems occur when one has a concept, but no legal definition for it. Hence is th
Different approaches have been used to test capital structure theories empirically. In this paper the statement that Myers and Majluf (1984) discussed, that a low risk debt issue should affect the firm value less than a high risk equity issue, is explored and tested by applying an event study approach similar to the one Eckbo (1986) carried out on different kinds of debt issuances. There are also
Populärvetenskaplig sammanfattning: Den ökande växthuseffekten, med påföljande klimatförändringar, framträder alltmer som ett av vår tids största miljöproblem. På grund av människans industriella och agrikulturella aktiviteter har atmosfärskoncentrationen av de viktiga växthusgaserna koldioxid (CO2), metan (CH4) och lustgas (N2O) ökat drastiskt. Med hjälp av modeller och beräkningar förutspås det Northern peatlands are important in the context of the climate change. Since they comprise huge amounts of soil organic carbon and are found where the most significant greenhouse warming is predicted, they have the potential to exert major feedback effects on the global warming. Studies of the greenhouse gas exchange in northern peatlands have mainly focused on the growing season when the soil is
Using the theoretical instruments given in Buzan and Weavers Regional Security Complex Theory, this thesis provides an updated analysis of the security dynamics in the Persian Gulf, a sub-complex in the Middle Eastern Regional Security Complex (MERSC). The method used was to compare the authors’ analysis of the core characteristics of the MERSC in general, and the Gulf in particular as perceived 2
The costs for producing machines have increased a lot in the latest years. For Presona this has meant that production costs for their main waste compactor needed to be cut in order to keep the compactor in their production line. The waste compactor was initially developed sometime in the 1960s when the price for construction materials and assembly allowed Presona to develop the compactor using a t
The aim of this Master's thesis is to construct an algorithm that nds the optimal credit limit for an individual credit card holder. It should be optimal in the sense that the algorithm suggests the lowest credit limit required for reaching the business goal of generating "X SEK within d days after limit raise" for the issuer of the credit card. This is achieved in three stages. Firs
