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OBJECTIVES: To standardise the colorimetric assay based on 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) for the rapid detection of rifampicin-resistant Mycobacterium tuberculosis in clinical practice and to evaluate the assay on a collection of 92 clinical isolates. DESIGN: The Bactec method was used as the reference method. Rifampicin was used for the susceptibility testing
Observations of the ultra-sharp-lined, chemically peculiar star chi Lupi taken by the Goddard High Resolution Spectrograph in echelle mode are presented. Thirty-six intervals of the spectral region between 1249 and 2688 Angstrom are covered with resolving powers in the range 75,000-93,000. Line identifications are provided, and the observed spectra are compared with synthetic spectra calculated us
Eleonora's Falcon (Falco eleonorae) breeds in the Mediterranean region and is highly adapted for catching small birds on passage migration between Eurasia and their African winter quarters, which they feed their young. We studied gliding flight behavior of Eleonora's Falcon at a breeding colony located on a small island southwest of Sardinia, Italy. Gliding and soaring flight performance was measu
Objective: To investigate the potential of acetic acid supplementation as a means of lowering the glycaemic index (GI) of a bread meal, and to evaluate the possible dose - response effect on postprandial glycaemia, insulinaemia and satiety. Subjects and setting: In all, 12 healthy volunteers participated and the tests were performed at Applied Nutrition and Food Chemistry, Lund University, Sweden.
We have recently discovered that the ZZ zinc finger domain represents a novel small ubiquitin-like modifier (SUMO) binding motif. In this study we identify the binding epitopes in the ZZ domain of CBP (CREB-binding protein) and SUMO1 using NMR spectroscopy. The binding site on SUMO1 represents a unique epitope for SUMO interaction spatially opposite to that observed for canonical SUMO interaction
The production of Z bosons with one or two isolated high-energy photons is studied using pp collisions at s=8 TeV. The analyses use a data sample with an integrated luminosity of 20.3 fb-1 collected by the ATLAS detector during the 2012 LHC data taking. The Zγ and Zγγ production cross sections are measured with leptonic (e+e-, μ+μ-, νν) decays of the Z boson, in extended fiducial regions defined i
The collective impacts of farmers' land management decisions on above ground ecosystem services (ES) and their implications for agriculture are poorly understood. Managing habitat to provide ES is costly but at the same time it can support higher yields through, e.g., pollination or natural pest control. Due to the mobility of ES-providers (bees, natural enemies) farmers providing habitat might al
BACKGROUND: Our aim was to investigate the prognostic potential of circulating dipeptidyl peptidase 3 (cDPP3) to predict mortality and development of organ dysfunction in a mixed intensive care unit (ICU) population, and for this reason, we analysed prospectively collected admission blood samples from adult ICU patients at four Swedish hospitals. Blood samples were stored in a biobank for later ba
A cell-based biosensor system was designed for monitoring an anaerobic process for treatment of high biochemical oxygen demand (BOD) levels in wastewater samples from a factory processing concentrated rubber latex. The BOD biosensor used immobilized mixed culture of microorganisms as the biological sensing element and an oxygen electrode as the transducer. The assay principle is based on the deter
Components that have defects after release, but not during testing, are very undesirable as they point to 'holes' in the testing process. Either new components were not tested enough, or old ones were broken during enhancements and defects slipped through testing undetected. The latter is particularly pernicious, since customers are less forgiving when existing functionality is no longer working t
The production of emulsions using milk as the continuous phase has a number of applications of interest from the food industry's point of view. In addition, producing an emulsion with a narrow drop size distribution is interesting since their increased stability could avoid Oswald ripening and creaming. Membrane emulsification is a novel technique which helps to obtain a narrower distribution comp
Despite recent improvement in adjuvant therapies, triple-negative, and ER+ subtypes of breast cancer (BC) with metastatic potentials remain the leading cause of BC-related deaths. We investigated the role of phosphatidylinositol-4-phosphate 5-kinase alpha (PIP5Kα), a key upstream factor of PI3K/AKT, and the therapeutic effect of PIP5Kα inhibitor on subtypes of BC. The clinical importance of PIP5K1Despite recent improvement in adjuvant therapies, triple-negative, and ER+ subtypes of breast cancer (BC) with metastatic potentials remain the leading cause of BC-related deaths. We investigated the role of phosphatidylinositol-4-phosphate 5-kinase alpha (PIP5Kα), a key upstream factor of PI3K/AKT, and the therapeutic effect of PIP5Kα inhibitor on subtypes of BC. The clinical importance of PIP5K1
