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BACKGROUND: National European cancer survival rates vary widely. Prolonged diagnostic intervals are thought to be a key factor in explaining these variations. Primary care practitioners (PCPs) frequently play a crucial role during initial cancer diagnosis; their knowledge could be used to improve the planning of more effective approaches to earlier cancer diagnosis. OBJECTIVES: This study sought t

The global environment suffers from utilizing fossil fuels to powering internal combustion engines (ICE), due to the massive amounts of released CO2. Besides the global impact, the local environments experience high concentrations of harmful pollutants such as NOx, CO, soot and particulate matter (PM). The automotive industry is continuously striving to find new solutions to decrease fuel consumpt

The European Union (EU) annually publishes an Innovation Union Scoreboard (IUS) as a tool to measure the innovation performance of EU Member States by means of a composite index, called the Summary Innovation Index (SII). The SII is constituted by an average of 25 indicators. The SII is claimed to rank Member States according to their innovation performance. This means that the higher the average

The ac frequency in electrical power systems is conventionally regulated by synchronous machines. The gradual replacement of these machines by asynchronous renewable-based generation, which provides little or no frequency control, increases system uncertainty and the risk of instability. This imposes hard limits on the proportion of renewables that can be integrated into the system. In this paper,

AbstractPhysical exhaustion can constrain human ascending work capacity and performance during emergency evacuation on stairs. The overall aim of this research was to explore and compare stair ascending capacities and physiological limitations during two different strategies: self-preferred pace in three different public stairways in the field, and controlled pace in a laboratory on a stair machin

Correct phenotypic interpretation of variants of unknown significance for cancer-associated genes is a diagnostic challenge as genetic screenings gain in popularity in the next-generation sequencing era. The Critical Assessment of Genome Interpretation (CAGI) experiment aims to test and define the state of the art of genotype-phenotype interpretation. Here, we present the assessment of the CAGI p1

Microbial communities play a major role in the degradation of soil organic matter (SOM) in soils. Despite its significance, the functional diversity of the highly diverse microbial communities is poorly understood. To address this, we applied a recently developed technique, captured metagenomics, to determine the effects of land-use on the functional genetic diversity of genes involved in the carb

Monitoring of ventricular premature beats (VPBs), being abundant in hemodialysis patients, can provide information on cardiovascular instability and electrolyte imbalance. In this paper, we describe a method for VPB detection which explores the signals acquired from the arterial and the venous pressure sensors, located in the extracorporeal blood circuit of a hemodialysis machine. The pressure sig

The performance of linear multi-user multiple-input multiple-output (MU-MIMO) systems has been extensively studied for classical statistical channel models. In contrast, there is little analysis for ray-based models, which are physically motivated, feature prominently in standards and have been experimentally validated. Thus, we present a novel analysis framework for zero forcing (ZF) and maximal

Background: Patent foramen ovale (PFO) is a contributor to embolic stroke of undetermined source (ESUS). Subgroup analyses from previous studies suggest that anticoagulation could reduce recurrent stroke compared with antiplatelet therapy. We hypothesised that anticoagulant treatment with rivaroxaban, an oral factor Xa inhibitor, would reduce the risk of recurrent ischaemic stroke compared with as

The ever-increasing consumption of natural resources required for the production of consumer electronics, and the growing amount of electronic waste, underline the importance and urgency of extending the lifespan and use of such products. Information and Communication Technology (ICT) remanufacturing is a growing industry, which nonetheless faces several barriers. Consumers often have a perception

The CKD-EPI creatinine-based estimation equation for glomerular filtration rate (GFR) cannot be used in children, overestimates GFR in young adults, and its combination with the KDIGO recommended pediatric CKiD (Schwartz bedside) equation causes implausible increases in estimated GFR when switching from pediatric to adult care. By establishing sex-specific creatinine growth curves for children and

The numerical simulation of the induction heating process can be computationally expensive, especially if ferromagnetic materials are studied. There are several analytical models that describe the electromagnetic phenomena. However, these are very limited by the geometry of the coil and the workpiece. Thus, the usual method for computing more complex systems is to use the finite element method to

Rainfall intensity or depth estimates are vital input for hydrologic and hydraulic models used in designing drainage infrastructures. Unfortunately, these estimates are susceptible to different sources of uncertainties including climate change, which could have high implications on the cost and design of hydraulic structures. This study adopts a systematic literature review to ascertain the disreg

Importance: Trastuzumab emtansine (T-DM1) is presently approved for treatment of advanced breast cancer and after incomplete response to neoadjuvant therapy, but the potential of T-DM1 as monotherapy is so far unknown. Objective: To assess pathologic complete response (pCR) to standard neoadjuvant therapy of combination docetaxel, trastuzumab, and pertuzumab (DTP) vs T-DM1 monotherapy in patients

The registration of an observed point set to a known model to estimate its 3D pose is a common task for the autonomous manipulation of objects. Especially in industrial environments, robotic systems need to accurately estimate the pose of objects in order to successfully perform picking, placing or assembly tasks. However, the characteristics of industrial objects often cause difficulties for clas

Background: The relationship between dyslipidemia, inflammation and CV organ damage in type 2 diabetes mellitus (T2DM) is complex. Insulin resistance and inflammatory cytokines interleukins (ILs) increase plasma triglycerides (TG). ILs also up-regulate expression of matrix-metalloproteinases (MMPs) that, together with TG, decrease high density lipoprotein cholesterol (HDL) levels. High TG, low HDL

The Galactic Archaeology with HERMES (GALAH) survey is a large-scale stellar spectroscopic survey of theMilkyWay, designed to deliver complementary chemical information to a large number of stars covered by the Gaia mission. We present the GALAH second public data release (GALAH DR2) containing 342 682 stars. For these stars, the GALAH collaboration provides stellar pa

Summary: The Natura 2000 network of protected sites is one of the means to address the issue of biodiversity conservation in Europe. Protected under the habitat directive, EU member states have to undertake surveillance of habitats and species of community interest and report every six years on habitat range and distribution, conservation status and the future prospects of the habitats within and