Filetype
Surface-enhanced Raman spectroscopy (SERS) is an ultrasensitive vibrational fingerprinting technique widely used in analytical and biosensing applications. For intracellular sensing, typically gold nanoparticles (AuNPs) are employed as transducers to enhance the otherwise weak Raman spectroscopy signals. Thus, the signature patterns of the molecular nanoenvironment around intracellular unlabeled A
BACKGROUND: Clinicians normally use subjective rating scales to estimate the impairment of patients with Parkinson's disease (PD). More objective and quantitative methods of assessment would greatly aid our understanding of the disease. One promising approach is to measure reaction time: the large amount of data recorded in a short period provides precise, reproducible evaluation of the underlying
Background: About two-thirds of patients with Alzheimer’s disease (AD) are women, mostly because of their longer life-span and the higher prevalence of AD among older persons. A more-pronounced association between AD pathology and dementia (faster brain atrophy) and more-rapid cognitive decline have been reported in women. The AD prognosis might be affected by, e.g., size of cerebral hemispheres,
We have recently discovered that the ZZ zinc finger domain represents a novel small ubiquitin-like modifier (SUMO) binding motif. In this study we identify the binding epitopes in the ZZ domain of CBP (CREB-binding protein) and SUMO1 using NMR spectroscopy. The binding site on SUMO1 represents a unique epitope for SUMO interaction spatially opposite to that observed for canonical SUMO interaction
A cell-based biosensor system was designed for monitoring an anaerobic process for treatment of high biochemical oxygen demand (BOD) levels in wastewater samples from a factory processing concentrated rubber latex. The BOD biosensor used immobilized mixed culture of microorganisms as the biological sensing element and an oxygen electrode as the transducer. The assay principle is based on the deter
A comprehensive on-line sample clean-up with an integrated two-dimensional HPLC system was developed for the analysis of natural peptides. Samples comprised of endogenous peptides with molecular weights up to 20 kDa were generated from human hemofiltrate (HF) obtained from patients with chronic renal failure. The (poly-)peptides were separated using novel silica-based restricted access materials w
BACKGROUND. The aim of this study was to compare Perfadex with Euro-Collins solution regarding 24-hour preservation of endothelium-dependent relaxation and vascular smooth muscle function. METHODS. The infrarenal aorta of 72 isogenic rats was studied in organ baths as fresh controls, after 24 hours of cold (4 degrees C) storage, and after 24-hour storage followed by transplantation and examination
Popular Abstract in Swedish Användandet av mer än en antenn för både sändare och mottagare i radiokommunikation kommer att spela en viktig roll för att uppnå den önskade dataöverföringshastigheten på upp till 1 gigabit per sekund i nästa generations kommunikationssystem. Detta eftersom tekniken, känd som multiple-input multiple-output (MIMO), ger en dataöverföringshastigheten som är proportionerliThe use of multi-antenna systems with multiple-input multiple-output (MIMO) technology will play a key role in providing high spectrum efficiency for next generation mobile communication systems. This thesis offers valuable insights on the design of compact multi-antennas for efficient MIMO communications. In the course of the thesis work, several novel six-port antenna designs have been proposed
Renewable energy sources (RES), especially wind turbines, have become more important during the last years. An increasing number of distributed generation (DG) units are connected to weak medium voltage distribution networks in rural areas where they have a large influence on the voltage and the line losses. Voltage rise is in this case often a limiting factor for the maximum amount of DG capacity
RF and DC characterization of vertical InAs nanowire MOSFET on Si substrates are presented. Nanowire arrays are epitaxially integrated on Si substrates by use of a thin InAs buffer layer. For device fabrication, high-k HfO2 gate dielectric and wrap-gates are used. Post-deposition annealing of the high-k is evaluated by comparing one annealed and one not-annealed sample. The annealed sample show be
In this essay I attempt to bring clarity to the discourse production within Zlatan Ibrahimović and David Lagerkrantz biography: Zlatan Ibrahimović: min historia (I Am Zlatan: My Story On and Off the Field). The biography describes the history of the football player Zlatan Ibrahimović, his background in the suburban area of Rosengård in Sweden, and his relationship towards football to mention a few
Although feminism is an ideologically-charged concept that allows for various interpretations, Sweden employs a feminist foreign policy with the aim of gender equality. Sweden also seizes the value of feminism in its nation branding efforts. This study problematizes Sweden’s use of feminism as nation branding concept. It aims for understanding how feminism is enacted in Sweden’s nation branding an
The family of proteins called galectins, are a group of carbohydrate-binding proteins. This allows them to take part in cell signalling by binding to glycoproteins on cell surfaces. Galectin-9 has been identified as a TIM3 ligand. TIM3 is a protein found on T-cells, which are used by the immune system to destroy for example cancer cells. When galectin-9 binds TIM3 it starts a reaction chain which
Habitat fragmentation is a common problem in relation with road infrastructure which leads to mortality, isolation of animal populations, and has a negative effect on biodiversity. Animal crossings have been implemented in many countries and are a useful tool to mitigate these problems but they are expensive to build. This thesis explores the methodological approaches used to evaluate how wildlife
We describe the characterization of the hydrodynamic properties of anisotropic magnetic nanoparticles using a combination of transmission electron microscopy (TEM) and dynamic as well as depolarized dynamic light scattering (DLS/DDLS). The particles used are nearly monodisperse hematite spindles with an average length of 280 nm and a minor axis of 57 nm, coated with a layer of silica of variable t
Recent findings show that human fibroblasts can be directly programmed into functional neurons without passing via a proliferative stem cell intermediate. These findings open up the possibility of generating subtype-specific neurons of human origin for therapeutic use from fetal cell, from patients themselves, or from matched donors. In this study, we present an improved system for direct neural c
Climate change is likely to have severe effects on water availability in Ethiopia. The aim of the present study was to assess the impact of climate change on the Gilgel Abay River, Upper Blue Nile Basin. The Statistical Downscaling Tool (SDSM) was used to downscale the HadCM3 (Hadley centre Climate Model 3) Global Circulation Model (GCM) scenario data into finer scale resolution. The Soil and Wate
In this paper two different concepts are analyzed: information disorder and cooperation. Psychological warfare has become an increasingly pressing problem during the past few years. Several different notions are being used within the concept, including disinformation, misleading information and information disorder. Problems occur when one has a concept, but no legal definition for it. Hence is th
