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The development of a plasmid-based genetic transformation protocol for Chlamydia trachomatis provides the basis for the detailed investigation of the function of the chlamydial plasmid and its individual genes or coding sequences (CDS). In this study we constructed a plasmid vector with CDS6 deleted (pCDS6KO) from the original Escherichia coli/C. trachomatis shuttle vector pGFP::SW2. pCDS6KO was t

Anaemia is a chief determinant of global ill health, contributing to cognitive impairment, growth retardation and impaired physical capacity. To understand further the genetic factors influencing red blood cells, we carried out a genome-wide association study of haemoglobin concentration and related parameters in up to 135,367 individuals. Here we identify 75 independent genetic loci associated wi

Background. In formal experiments on software engineering, the number of factors that may impact an outcome is very high. Some factors are controlled and change by design, while others are are either unforeseen or due to chance. Aims. This paper aims to explore how context factors change in a series of for- mal experiments and to identify implications for experimentation and replication practices

Recent multi-stage genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) that are robustly associated with chronic lymphocytic leukaemia (CLL) risk. Given that most of these SNPs map to non-coding regions of the genome, it suggests that the functional basis of many GWAS signals will be through differential gene expression. By referencing publically accessibl

The effects of continuous and intermittent inhalation of perchloroethylene (PCE) on plasma butyrylcholinesterase (BuChE) activity, organ weights, liver morphology and motor activity in mice (strain NMRI) were tested. PCE exposure increased plasma BuChE activity in a time- and concentration dependent manner in both sexes. The increase was statistically significant at 37 p.p.m. in animals continuous

To contribute to the body of empirical research on fault distributions during development of complex software systems, a replication of a study of Fenton and Ohlsson is conducted. The hypotheses from the original study are investigated using data taken from an environment that differs in terms of system size, project duration, and programming language. We have investigated four sets of hypotheses

Popular Abstract in Swedish I denna avhandling har användbarheten av Virtual Reality (VR) utvecklats och undersökts för två användningsområden: participatorisk design av arbetsplatser och hjärnskaderehabilitering. Inom det första användningsområdet används VR tillsammans med fullskalemodellering, drama och demokratisk mötesteknik i en Visualiseringsverkstad. Denna arbetsmetod har utvecklats och tIn this thesis, the usability of Virtual Reality (VR) has been investigated and developed within two applications: participatory design of workplaces and brain injury rehabilitation. In the first application, VR is used in combination with full scale modelling, drama and democratic meetings in an Envisionment Workshop. This workshop has been developed and tested through several real workplace int

Chronic obstructive pulmonary disease (CCPD) is a disease primarily caused by cigarette smoking, which in turn has been shown to affect the susceptibility to and progression of airway infections. The question addressed in this study was how components from cigarette smoke could affect the defence mechanisms of T-cells and epithelial cells, and thereby contribute to the development of the COPD path

Glycobiology is the world of sugars: how they are made, what they look like, and what they do. Despite the importance of glycan structures in life, knowledge has been hampered due to their inherent complexity. Lectins are nature's way to decipher the intricate code held by glycans, which makes them important players in both normal and pathological physiology. A key to the understanding of lectins

LTH ny tt lunds tekniska högskolas nyhetsmagasin | nummer 1 | 2012 Ordförande Treschow presenteras CoacHing i Helsingborg Forskarskola i arkitektur TEMA: ENERGI LTH – sprudlar av energi LTH är fyllt av en osedvanligt stor mängd av energiska män- niskor som dessutom arbetar med energifrågor av olika slag. Energi genomsyrar verkligen vår verksamhet. För några år sedan bestämde sig ett universitet i

https://www.lth.se/fileadmin/lth/omlth/kommunikation/lthnytt/LTHnytt_12.pdf - 2026-06-07

The transcriptional response in the parasitic fungus Monacrosporium haptotylum and its nematode host Caenorhabditis elegans were analyzed during infection using cDNA microarrays. The array contained 2,684 fungal and 372 worm gene reporters. Dramatic shifts occurred in the transcriptome of M. haptotylum during the different stages of the infection. An initial transcriptional response was recorded a

Neuroblastoma is a childhood malignancy originating from cells of the sympathetic nervous system, exhibiting a marked diversity in outcome, with spontaneous regression at one end of the spectrum and severe disease and death at the other end. Features associated with frequent recurrence, a poor prognosis, and high tumor stage are loss of heterozygosity in the distal region of chromosome 1p and ampl

Information about genetic variation has been collected for some 20 years into registries, known as locus specific databases (LSDBs), which nowadays often contain information in addition to the actual genetic variation. Several issues have to be taken into account when considering establishing and maintaining LSDBs and these have been discussed previously in a number of articles describing guidelin

Popular Abstract in Swedish Höftfraktur är en vanlig skada, som huvudsakligen drabbar äldre kvinnor, och oftast orsakas av ett ringa våld. Det är vanlig orsak till funktionsnedsättning, sjuklighet och dödlighet hos de äldre. Både incidensen (antal nya fall per antal innevånare och år) av höftfrakturer och det totala antalet har ökat de senaste årtiondena. Höftfrakturer medför stora kostnader för sHip fractures are a common cause of morbidity and mortality in elderly patients, with a high risk of functional impairment and institutionalization. The incidence and number of hip fractures have increased during the recent decades and hip fractures consume considerable health-care resources. The incidence of hip fractures in Malmö, Sweden, 1992–95, is described in Paper I. The annual incidence pe

Basic English Grammar A web linked course Basic English Grammar is not a grammar book per se, with para­graphs and rules, but a course designed specifically for speakers of Swedish who wish to improve their proficiency and confidence in English. Since most Swedish speakers have a great deal of intuitive knowledge about the structure of the English language, the authors have integrated exercises i

Background: Periodontal research has traditionally focused on the site level, regarding etiology, pathogenesis, and treatment outcome. Recently, some studies have indicated that the presence of periodontal disease is associated with reduced quality of life. The aim of this study is to investigate the impact of periodontal disease experience on the quality of life. Methods: This cross-sectional stu