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Background. In the European Study for Pediatric Ph+ ALL (EsPhALL), a total of 128 patients aged 1 to 18 years diagnosed with ALL and evidence of t(9;22)(q34;q11) received post-Induction Imatinib on top of BFM high risk chemotherapy backbone, either in Good Risk (GR) (after randomization, n=58) or in Poor Risk (PR) (n=70), as defined according to early response to the National induction treatment.

In January 1990 an expert group was set up by DP2 of TC2, CEC to define the research and development work needed to be undertaken within the community to achieve a robust solution with respect to reaction-to-fire material classification. The expert group delivered in December 1990 its proposal for a 5-year research and development program. But a system of harmonised European fire test methods and

The rheology of dense suspensions in the viscous regime can be characterized by the viscous number J and granular flows by the inertia number I, both relating the shear rate γ - to the confining pressure P. Furthermore, several works have shown that the rheology of suspensions and granular flows can be unified, and this unification is used to characterize suspensions with non-negligible particle i

Si fluxes from the continents to the ocean are a key element of the global Si cycle. Due to the ability of coastal ecosystems to process and retain Si, the ‘coastal filter’ has the potential to alter Si fluxes at a global scale. Coastal zones are diverse systems, sensitive to local environmental changes, where Si cycling is currently poorly understood. Here, we present the first palaeoenvironmenta

Converting resident glia in the brain into functional and subtype-specific neurons in vivo provides a step forward towards the development of alternative cell replacement therapies while also creating tools to study cell fate in situ. To date, it has been possible to obtain neurons via in vivo reprogramming, but the precise phenotype of these neurons or how they mature has not been analyzed in det

The built environment is still, to a large extent, not accessible and usable for all. The awareness of people's different conditions and abilities sometimes seems to be far from the agenda for planning and architecture. Universal Desing (UD) is pointed out as a strategy to achieve a built environment for all people regardless of age and abilities. UD has a radical potential to bring about change a

An accident on a passenger ferry may lead to evacuation using lifeboats or liferafts, a process that can be both complex and hazardous. This paper investigates the level of safety for passengers during evacuation based on field study and interview data. In the analysis, the eight goals of Universal Design (UD) were tailored and used to explore what ship and interior characteristics influence evacu

Background & objectives: Endoscopy is the current gold standard for evaluation of disease activity in ulcerative colitis. The Mayo Endoscopic Subscore (MES) is commonly used for quantifying disease activity, but it has several weaknesses. Numerous new endoscopic indices have been developed but none of these have been widely implemented, likely due to limited feasibility. The primary objective

Aims Alternative splicing of Titin (TTN) I-band exons produce protein isoforms with variable size and elasticity, but the mechanisms whereby TTN splice factors regulate exon usage and thereby determining cardiomyocyte passive stiffness and diastolic function, is not well understood. Non-coding RNA transcripts from the antisense strand of protein-coding genes have been shown to regulate alternative

A novel material composition has been investigated in terms of thermal, mechanical, economical and sustainable aspects to be compared to neoprene wetsuits. It is believed that a sandwich structure produced by a dipping method with rubber layers containing an insulating textile can insulate better than foamed neoprene. The hypothesis is also that this sandwich structure can increase durability and

Urban areas are responsible for a significant part of greenhouse gas emissions. Megacities, especially, have cumulative impacts due to different anthropogenic heat sources and urban heat island phenomena. It is therefore vital to replace fossil fuel burning heating sources with renewable sources in the current building stock. Renewable energy sources can be applied through building energy retrofit

Före ändringarna i fastighetsbildningslagen på 90-talet gick det inte bilda nya fastigheter som var storleksmässigt mellan bostadsfastigheterna på max ca 2 ha och jord- och skogsbruksfastigheterna som skulle vara stora nog att ge ett ekonomiskt godtagbart utbyte, alltså minst flera tiotalet ha stora. Tonkilometermetoden som används för att beräkna andelstal för gemensamhetsanläggningar har uppdateThere is an undefined area in the method to calculate new participatory shares in a joint facility of roads. The boundary between residential and agricultural property units is unclear in the method since the change of law of property formation in 1991 and 1994 when large residential property units and small agricultural property units were allowed. Before the residential property units could not

Developing a new tool for the study of human brain development “If the human brain were so simple that we could understand it, we would be so simple that we couldn’t” physicist Emerson Pugh once said. Nevertheless, despite its complexity, researchers are trying to figure out one of the human body's most vital organs. Understanding the development of the brain is crucial to understanding how i

A Kondo lattice skyrmion model in contact with a macroscopic environment is simulated to explore skyrmion dynamics, which is an extension of previous work. The system is simulated using non-equilibrium Green's functions within the generalized Kadanoff-Baym ansatz and the wide band limit. To get a time-linear scaling, we present an approximation to the collision integral, which offers a good tr

Begreppet rättssäkerhet används ofta både inom och utom den rättsvetenskapliga sfären. Eftersom man inte sällan möter det i den allmänna debatten i Sverige, syftar den här uppsatsen till att undersöka om begreppet i det sammanhanget används i samma betydelse som inom rättsvetenskapen. Undersökningen tar avstamp i vad framstående svenska rättsvetare har uttryckt ifråga om att definiera begreppet r

Förtalsbrottet syftar till att skydda den enskilde från ärekränkningar och utgör således en tillåten inskränkning i den grundlagsstadgade tryck-och yttrandefriheten. I bestämmelsen har lagstiftaren uppställt en ansvarsfri-hetsregel som tar sikte på huruvida uppgiftslämnandet varit försvarligt eller ej. Som redogörelsen visar, saknas försvarlighetsbedömningar i ett flertal avgöranden där samtliga bThe crime of defamation (in the fifth chapter of the Swedish Penal Code) aims to protect an individual against violations that target the said individ-ual's honour, thus provides a restriction on the constitutional freedom of press and freedom of speech. In the regulation, one can be exempt from liability depending on whether the disclosure of information was justifiable or not. As this paper

This thesis critically assesses the integration of social sciences and interdisciplinarity within the international science-policy interfaces Intergovernmental Panel on Climate Change (IPCC) and Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES). I depart from a theoretical framework using the concepts of academic disciplines, interdisciplinary work and scient