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OBJECTIVES: To evaluate the safety of intra-articular sprifermin (primary), and to evaluate systemic exposure, biomarkers, histology, and other cartilage parameters in patients with advanced osteoarthritis (OA).METHODS: This was a first-in-human, double-blind, randomised, placebo-controlled trial of single and multiple ascending doses of sprifermin from 3-300 μg in knee OA patients scheduled for t

Background: Whether disease burden in patients with metastatic castration-sensitive prostate cancer (mCSPC) predicts treatment outcomes is unknown. We assessed apalutamide treatment effect in TITAN patients with mCSPC by disease volume, metastasis number and timing of metastasis presentation. Methods: These protocol-defined and post hoc analyses of the phase III randomised TITAN study evaluated cl

Background: The incidence of melanoma in situ (MIS) is increasing even more rapidly than the incidence of cutaneous malignant melanoma (CMM). No previous studies have in detail investigated the survival in individuals diagnosed with MIS compared to the general population. Methods: This population-based study included individuals with MIS diagnosed in Sweden between 2001 and 2010 and randomly selec

Extraction of vitamin D, including its hydroxylated and esterified metabolites, from soft tissues such as the liver is challenging due to the lipophilic character of matrix and analytes that are expected in very low concentration levels. In this study, we aimed at the optimization of two-step extraction using solid–liquid extraction as the first step, followed by solid-phase extraction. Various so

BACKGROUND: Parkinson's disease (PD) is a chronic neurodegenerative disorder. There is limited knowledge about the function of the hypothalamic-pituitary-adrenal axis in PD. The primary aim of this prospective study was to analyze diurnal salivary cortisol concentrations in patients with PD and correlate these with age, gender, body mass index (BMI), duration of PD, and pain. The secondary aim was

The present work describes the formation of low-aspect-ratio Ag nanoparticles (NPs) arrays by sequential deposition of Ag from different growth directions on a nanoripple-patterned Si substrate, produced by low-energy ion beam irradiation. It is observed that the growth of Ag-NPs on ripple surfaces is direction-dependent due to the asymmetric ridge of the ripple pattern. This asymmetric ridge can

Background/aims: Congestion is prognostically relevant in cardiac transthyretin amyloidosis (ATTR-CA), but whether congestion has an incremental prognostic value beyond the well-established, congestion-sensitive NT-proBNP is unknown. Therefore, we aimed to comparatively evaluate the prognostic utility of several congestion surrogates over NT-proBNP. Methods: We estimated hazard ratios by Cox propo

Clinical outcome after traumatic diffuse axonal injury (DAI) is difficult to predict. In this study, three magnetic resonance imaging (MRI) sequences were used to quantify the anatomical distribution of lesions, to grade DAI according to the Adams grading system, and to evaluate the value of lesion localization in combination with clinical prognostic factors to improve outcome prediction. Thirty p

Humans have dramatic, diverse and far-reaching influences on the evolution of other organisms. Numerous examples of this human-induced contemporary evolution have been reported in a number of ‘contexts’, including hunting, harvesting, fishing, agriculture, medicine, climate change, pollution, eutrophication, urbanization, habitat fragmentation, biological invasions and emerging/disappearing diseas

Forest degradation, forest fires, and wildlife poaching have devastated biodiversity in Indonesia. To assess the impact of forest degradation and the potential for recovery, we used birds as a proxy for biodiversity and assessed density estimates (hereafter density) in the degraded lowland forest of Harapan Rainforest Ecosystem Restoration Concession (HRF) in Sumatra. In this study, a total of 149

Senior lecturer Contact details Email: niklas [dot] selberg [at] jur [dot] lu [dot] seOrganisation Department of Law Service point: 56 WebpageNiklas Selbergs profile in Lund University research portalOther affiliations Researcher Lund University Centre for Business Law (Swedish abbr: ACLU) Researcher Human Rights Law Profile area member LU Profile Area: Human rights Researcher Health Law Researche

https://www.law.lu.se/niklas-selberg - 2026-05-14

Senior lecturer Contact details Email: niklas [dot] selberg [at] jur [dot] lu [dot] seOrganisation Department of Law Service point: 56 WebpageNiklas Selbergs profile in Lund University research portalOther affiliations Researcher Lund University Centre for Business Law (Swedish abbr: ACLU) Researcher Human Rights Law Profile area member LU Profile Area: Human rights Researcher Health Law Researche

https://www.humanrights.lu.se/niklas-selberg - 2026-05-14

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Human Rights Forum Archives - Page 8 of 10 - The Raoul Wallenberg Institute of Human Rights and Humanitarian Law Skip to content Search for: Search Button Home About Us Who We Are Our History About Raoul Wallenberg Our Theory of Change Staff Opportunities Annual Reports Whistleblower Our work What we do Multi-Disciplinary Research Higher Education Strategic Advice and Analysis Outreach Evaluation

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The purpose of this thesis is to describe and analyze the development of the agriculture in the county of Skåne (Scania) and to see if there are explanations to be found why the agricultural land is exploited today. By theories from human ecology I discuss the interconnections between human, nature and society both in a historical and a present perspective. Focus is on how the landscape, humans an

A combination of acoustic trapping and impedance spectroscopy for micrometer-sized objects is here presented for the first time. Acoustic trapping has proven to be a well-functioning method for non-contact immobilization and positioning of particles or cells in microfluidic channels. The combination with impedance spectroscopy allows for simultaneous electrical measurements on the trapped objects.

Som ett resultat av industrialiseringen ändrades varumärkets primära funktion efterhand till att gälla mer i relationen mellan konsumenter och företag. Den tekniska utvecklingen och globaliseringen har lett till en företagskultur där lokala handlare med lokal och i viss mån nationell kundkrets har ersatts av stora kedjor med världsomspännande försäljningsmöjligheter. Förändringarna har resulteraThe primary function of a trade mark changed as a result of the industrialisation period. As time passed the importance moved to regard the relationship between consumers and companies. The technical revolution and globalisation has led to a business culture where local and national vendors have been replaced by giant chains with sales opportunities across the world. The outcome of the modificat

In the recent decades, one of the most phenomenal changes in many universities in Western countries is the dramatically increase of students from China. Subsequently, the thesis author mentioned that general view concerning educational tourism associates educational tourists with the international students’ mobility. This has emerged as an important part of the university students’tourism market.

This master’s dissertation comprises a life cycle assessment (LCA) of a changing table, which mainly constitutes of FSC certified wood. Results per functional unit showed global warming potential of 12,5 kg CO2 eq, creation of ground level ozone 2,17 g C2H4 eq, emitting of acidifying substances 39,4 g SO2 eq and energy consumption 93,5 MJ during the estimated product life length of 12,5 years. The

Hyran för kommersiella lokaler regleras utifrån principen om marknadshyra, vilken sätts av ingående kontrakt mellan hyresvärd och hyresgäst. Hyresavtalen beror vanligtvis på lokalens fastighetsanknutna attribut och medför givetvis att hyresnivåerna kommer att skilja sig åt mellan varje enskilt kontrakt. Förfarandet vid avtalsupprättande är välbeprövat och finns reglerat i Jordabalken (1979:994). SThe rents for commercial premises are regulated by the principle of market rent, which are set by contracts between landlords and tenants. The leases typically depends on the property related attributes and naturally means that rental levels will differ between each individual contract. However, according to the Swedish property indicator, the general rent levels of commercial stores and offices,