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The daily transition between day and night, known as the diel cycle, is characterised by significant shifts in environmental conditions and biological activity, both of which can affect crucial ecosystem functions like pollination. Despite over six decades of research into whether pollination varies between day and night, consensus remains elusive. We compiled the evidence of diel pollination from
Background: The TrialNet Oral Insulin (OI) prevention trial showed no overall treatment effect, using the diagnosis of type 1 diabetes as an endpoint. A significant delay in onset was only found in a high-risk stratum (termed secondary stratum 1) of participants with low first-phase insulin release (FPIR).Methods: Since trials with an endpoint of type 1 diabetes take years to complete, in this pos
Drought is a multifaceted phenomenon driven by both natural climate fluctuations and human activities. Unlike traditional, slow-developing droughts, flash droughts (FDs) emerge suddenly and intensify rapidly, posing significant challenges for natural resource management. The lack of effective tools to quantify FDs exacerbates stakeholders' concerns, particularly due to the risks they pose to water
Accurate maps of past land cover and human land use are necessary for studying the impact of anthropogenic land-cover changes, such as deforestation, on the climate. The maps of past land cover should ideally be separated into naturally occurring vegetation and human-induced changes, thereby enabling the quantification of the effect of human land use on the past climate. A Bayesian hierarchical mo
Background: The 2020 European Society of Cardiology (ESC) guidelines for the diagnosis and management of patients with non-ST elevation-acute coronary syndrome (NSTE-ACS) recommend early invasive coronary angiography in high-risk patients and no routine pre-treatment with oral P2Y12 receptor inhibitor in NSTE-ACS patients prior to defining coronary anatomy. Objective: To assess the implementation
The growing season start and duration, along with other temperature-related measures of importance to premium wine grapes in Napa Valley, California have changed as climate over the western United States has warmed. The growing season start has varied from year to year with a standard deviation of about 3 weeks, but over the 1958–2016 record a linear fit to the time sequence shows it advanced by m
We provide a detailed account of the origin and establishment of the Osteoarthritis Research Society International (OARSI) and celebrate its history from inception to the current day. We discuss the mission, vision and strategic objectives of OARSI and how these have developed and evolved over the last 3 decades. We celebrate the achievements of the society as we approach its 30th birthday, honor
We determined the concentration of markers in cartilage and synovium metabolism in the synovial fluid (SF) of the knee of young beagle dogs with slowly progressive osteoarthrosis. Osteoarthrosis (OA) was induced by a tibial 30°valgus osteotomy to the right hindlimb of 16 dogs. The contralateral knee served as control. The animals were killed 7 (group I) and 18 months (group II) after operation. Th
Asisted living (AL) technologies, enabled by technical advances such as the advent of the Internet of Things, are increasingly gaining importance in our aging society. This article discusses the potential of future high-accuracy localization systems as a key component of AL applications. Accurate location information can be tremendously useful to realize, e.g., behavioral monitoring, fall detectio
Many modern software applications have performance requirements, like mobile and embedded systems that must keep up with sensor data, or web services that must return results to users within an acceptable latency bound. For such applications, the goal is not to run as fast as possible, but to meet their performance requirements with minimal resource usage, the key resource in most systems being en
The main challenge for future electricity systems is to match the available electricity from variable renewable resources with the electricity demand in place, time and quantity. One option for increasing electricity system flexibility is to integrate the electricity system with the district heating systems via the use of power-to-heat technologies such as electric boilers. The overarching objecti
Hemicelluloses, which are abundant in nature and have potential use in a wide variety of applications, may make an important contribution in helping relieve society of its dependence on petrochemicals. However, cost-efficient methods for the isolation of hemicelluloses are required. This article presents an economic evaluation of a full-scale process to isolate hemicelluloses from process water fr
The recreational drug ecstasy [3,4-methylenedioxymethamphetamine (MDMA)], has been found to selectively damage brain serotonin neurons in experimental animals, and probably in human MDMA users, but detailed morphometric analyses and parallel functional measures during damage and recovery are missing. Since there is evidence that serotonin regulates sleep, we have compared serotonergic markers para
The intraobserver reproducibility of ultrasonic volume blood flow measurements in the human fetus was evaluated in this study. A new approach, simultaneous measurement of the vessel diameter and the flow velocity with a pulsed-wave Doppler ultrasound synchronized with a real-time ultrasound phase-locked echo-tracking system, was used to estimate volume blood flow (VBF) in the fetal descending aort
BACKGROUND Linomide, Figure 1, produces robust and consistent in vivo growth inhibition of prostate cancer models via its anti-angiogenic activity and inhibition of autoimmune encephalomyelitis models of multiple sclerosis (MS). MS clinical trials were discontinued because of unacceptable toxicity, due to dose-dependent induction of proinflammation. METHODS Therefore, linomide analogs were initia
The key reaction of protein synthesis, peptidyl transfer, is catalysed in all living organisms by the ribosome - an advanced and highly efficient molecular machine. During the last decade extensive X-ray crystallographic and NMR studies of the three-dimensional structure of ribosomal proteins, ribosomal RNA components and their complexes with ribosomal proteins, and of several translation factors
The aim of the study was to examine the relationship between the plasma concentration of cyclic guanosine monophosphate (cGMP) and pulmonary pressure and hypoxia defined by oxygenation index (OI) in newborn infants with severe persistent pulmonary hypertension (PPHN) on inhaled nitric oxide (NO). In this prospective study, 18 newborn infants having Doppler ultrasound-diagnosed PPHN and treated wit
Utopia. The Right to Hope27.09.2025 – 11.01.2026“You may say I’m a dreamer, but I’m not the only one,” wrote John Lennon and Yoko Ono in the opening lines of “Imagine,” one of the world’s most famous songs. Though the song is more than half a century old, its vision of various utopian ideals remains relevant today: a world without war, hunger, greed, and hatred—a peaceful, sustainable, and livable
A search for neutral long-lived particles (LLPs) decaying in the ATLAS hadronic calorimeter using 140 fb−1 of proton-proton collisions at s = 13 TeV delivered by the LHC is presented. The analysis is composed of three channels. The first targets pair-produced LLPs, where at least one LLP is produced with sufficiently low boost that its decay products can be resolved as separate jets. The second an
This paper examines how the concept ‘nature-positive’ as a means to enhance biodiversity is defined and used, viewed through the lens of power. Building on a three-dimensional conceptualization of power, we elaborate on i) how ‘nature-positive’ enters and remains on business and policy agendas, ii) different interpretations from both ecological and business perspectives, and iii) the governance of
