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UNLABELLED: Studies investigating the immunogenicity of additional COVID-19 vaccine doses in immunosuppressed patients with inflammatory rheumatic diseases (IRD) are still limited. The objective was to explore the antibody response including response to omicron virus subvariants (sBA.1 and sBS.2) after third and fourth COVID-19 vaccine doses in Swedish IRD patients treated with immunomodulating dr

We investigate the impact of a galaxy’s merger history on its system of satellites using the new VINTERGATAN-GM suite of zoom-in hydrodynamical simulations of Milky Way-mass systems. The suite simulates five realizations of the same halo with targeted ‘genetic modifications’ of a z ≈ 2 merger, but resulting in the same halo mass at z = 0. We find that differences in the satellite stellar mass func

Understanding the post-senescent fate of fungal mycelium is critical to accurately quantifying forest carbon and nutrient cycling, but how this organic matter source decomposes in wood remains poorly studied. In this study, we compared the decomposition of dead fungal biomass (a.k.a. necromass) of two species, Mortierella elongata and Meliniomyces bicolor, in paired wood and soil plots in a boreal

Microbicides in the leather industries are employed to avoid the biodeterioration of the hides by microorganisms. This problem may lead to harmful characteristics to the end product such as stains, roughness and decrease mechanical properties of leather. Therefore, microbicides like the 2-(thiocyanomethylthio) benzothiazole (TMCTB) are applied in distinct steps of the tanning process as alternativ

The paper unpacks the relationship between local culture and agency to enhance our understanding of local variations of agency. The paper studies two former old industrial places in Sweden; one place characterized by an entrepreneurial culture (Borås), the other with a company town culture (Kiruna). Both cases experienced structural crisis around 1970s. A study period of more than 30 years is used

We exhibit families of 4-CNF formulas over n variables that have sums-of-squares (SOS) proofs of unsatisfiability of degree (a.k.a. rank) d but require SOS proofs of size nΩ ( d ) for values of d = d(n) from constant all the way up to nδ for some universal constant δ. This shows that the nO ( d ) running time obtained by using the Lasserre semidefinite programming relaxations to find degree-d SOS

Sera from 40 Swedish children diagnosed as having Type 1 (insulin-dependent) diabetes mellitus during a one year period along with 40 age and geographically matched control subjects were tested for antibodies to a Mr-64000 islet protein by immunoprecipitation of 35S-methionine-labelled rat islet amphiphilic proteins. Of the 40 diabetic patients, 29 (73%) were found to be positive whereas all 40 co

Combined U-Pb, O and Lu-Hf isotope analyses of detrital zircon grains from five major rivers in Ghana are used to investigate the growth and evolution of the Birimian terrane of the West African Craton. The majority of the analysed zircon yields supra-chondritic εHf values, suggesting derivation from primarily juvenile host magmas. Zircon grains from the Birim River in southwestern Ghana deviate f

Silicon (Si) is the second most abundant element in the Earth’s crust and is an important nutrient in the ocean. The global Si cycle plays a critical role in regulating primary productivity and carbon cycling on the continents and in the oceans. Development of the analytical tools used to study the sources, sinks, and fluxes of the global Si cycle (e.g., elemental and stable isotope ratio data for

The current pandemic SARS-CoV-2 has required an unusual allocation of resources that can negatively impact chronically ill patients and high-complexity procedures. Across the European Reference Network on Pediatric Transplantation (ERN TransplantChild), we conducted a survey to investigate the impact of the COVID-19 outbreak on pediatric transplant activity and healthcare practices in both solid o

Base-catalysed depolymerisation of lignin using sodium hydroxide has been shown to be an effective approach towards exploiting industrial (technical) lignins within the pulp and paper industry. In the present work, a pine kraft lignin (Indulin AT) which is precipitated from black liquor of linerboard-grade pulp was depolymerised via base catalysis to produce low-molecular-mass aromatics without an

The safety and pharmacokinetics of carbetocin, a long-acting oxytocin analogue, were studied in 25 healthy nonpregnant women. The distribution and elimination half-lives of a 0.4-mg intravenous dose were found to be 5.5 ± 1.6 minutes and 41 ± 11.9 minutes, respectively. Similarly, the half-lives of a 0.8-mg intravenous dose were found to be 6.1 ± 1.2 minutes and 42.7 ± 10.6 minutes. Approximately

The momentum measurement capability of the ATLAS muon spectrometer relies fundamentally on the intrinsic single-hit spatial resolution of the monitored drift tube precision tracking chambers. Optimal resolution is achieved with a dedicated calibration program that addresses the specific operating conditions of the 354 000 high-pressure drift tubes in the spectrometer. The calibrations consist of a

Case-control and cohort studies published between 1977 and 1988 were reviewed with the purpose to evaluate the relationship between use of oral contraceptives (OC-use) and breast cancer risk, tumour biology and tumour prognosis with special emphasis on early OC-use. the risk of breast cancer was assessed in 30 case-referent studies and 5 cohort studies, and the prognosis of breast cancer had been

Stiff, elastic, viscous shear thinning aqueous gels are formed upon dispersion of low weight percent concentrations of cationically modified cellulose nanofibrils (CCNF) in water. CCNF hydrogels produced from cellulose modified with glycidyltrimethylammonium chloride, with degree of substitution (DS) in the range 10.6(3)-23.0(9)%, were characterised using NMR spectroscopy, rheology and small angle

The effect of protein kinase C (PKC) inhibitors on the induction of endothelin ET(B) receptors during organ culture was examined in isolated segments of the rat mesenteric artery. After 24 h of organ culture, the endothelin ET(B) receptor agonist sarafotoxin 6c (S6c) induced a strong contraction compared to fresh segments. The contractile response after 24-h organ culture to S6c was studied in pre

The human polymnaviruses JC virus (JCV) and BK virus (BKV) are oncogenic in experimental systems and commonly infect humans. JCV DNA has been reported to be present in human colon mucosa and in colorectal cancers. To investigate whether the risk for colorectal cancer is associated with JCV or BKV infection, we performed a case-control study nested in the Janus biobank, a cohort of 330,000 healthy

The microstructure and the capillary pressure of the pore space are important variables for better understanding of the complex phenomena occurring during vacuum impregnation (VI) of plant tissues. In this study, we used GASMAS (Gas in Scattering Media Absorption Spectroscopy) of oxygen to, non-destructively, measure the dynamics of the internal pressure in apple pieces after restoration of the at

Spatial and temporal variations in polychlorinated biphenyl (PCB) concentrations were studied in precipitation at 11 sampling-sites over a period of 1 year and compared with PCB concentrations in the air. The study was carried out in a region of southern Sweden approximately 11 000 km2 in area. The PCB concentration in precipitation ranged between 1.18 and 81.4 ng l(-1). Two of the sampling sites