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Background. Splenectomy is accompanied by a life-long risk of overwhelming postsplenectomy infection (OPSI), mainly caused by polysaccharide (PS) encapsulated bacteria such as Streptococcus pneumoniae. Despite extensive prophylactic efforts the mortality and morbidity rates remain high. The present study was based on a strategy with a predefined vaccination algorithm including repeated 23-valent p

In 2001, when the Taliban decided to destroy numerous cultural artefacts, including two colossal Buddha statues, that they considered incompatible with their faith, a large outcry was heard across the Western world. From the UNESCO to the British Museum, and from the Dalai Lama to countless head of governments, all were united in condemning this act of ’cultural terrorism’ that was said to prove n

Enhanced biological phosphorus removal (EBPR) was studied in laboratory scale experiments as well as in a full scale EBPR process. The studies were focused on carbon source transformations, the use of nitrate as an electron acceptor and characterisation of the microflora. A continuous anaerobic/aerobic laboratory system was operated on synthetic wastewater with acetate as sole carbon source. An ef

A national debate about how to transform and to ‘green’ the problematic housing stocks from the boom era has been going on since the late 1990s. Different kinds of policy instruments with energy efficiency objectives that address either energy systems, energy sources or construction and renovation of the building envelope have been in use. Some policy instruments have combined green objectives wit

Reliable estimates of past land cover are critical for assessing potential effects of anthropogenic land-cover changes on past earth surface-climate feedbacks and landscape complexity. Fossil pollen records from lakes and bogs have provided important information on past natural and human-induced vegetation cover. However, those records provide only point estimates of past land cover, and not the s

Large-scale multi-species data on population changes of alpine or arctic species are largely lacking. At the same time, climate change has been argued to cause poleward and uphill range shifts and the concomitant predicted loss of habitat may have drastic effects on alpine and arctic species. Here we present a multi-national bird indicator for the Fennoscandian mountain range in northern Europe (F

The Sahel lies in the semi-arid zone of North Africa between the Sahara Desert to the north and the savannas and rainforest to the south. In the Sahel, the variability of vegetation growth is predominately controlled by moisture reception in the concurrent rainy season. The inter-annual variability of normalized difference vegetation index (NDVI) during the rainy season (April to August) can be ex

How can a small fire at a subcontractor in the USA lead to a multimillion dollar loss at a Swedish telephone company, and how can a single machine breakdown lead to a complete production stop at a production company? With today logistics and production trends, where terms such as Lean Production, Six Sigma, 5S, and World Class Manufacturing are used every day, production companies are introducing

The thesis is regarding communicative urban planning and power relations, applied at a case called Brunnshög. The Brunnshög projects consist of five developing areas located in the north-east of Lund. The projects are pilot projects in communicative urban planning and the intension from the municipality is to involve the citizens and the developers in new ways, other than the traditional ones. T

Chronic neural interfaces that are able to record or stimulate neurons in the CNS are valuable instruments in use today and they hold great promise for the future both within neuroscience research and in the clinic. However, a major obstacle is that they show a decline in performance over time. Many different approaches to improve the interface designs are gradually evaluated in hope of overcoming

The aim of the present study was to enhance our understanding of vegetables as living organisms, interacting dynamically with the environment, and to explore the possible influence of metabolic changes on subsequent processing operations. Growing conditions, harvesting and handling in the packing house and storage conditions are key events leading to a defined “physiological status” of the vegetab

[Context] The continuous inflow of bug reports is a considerable challenge in large development projects. Inspired by contemporary work on mining software repositories, we designed a prototype bug assignment solution based on machine learning in 2011-2016. The prototype evolved into an internal Ericsson product, TRR, in 2017-2018. TRR’s first bug assignment without human intervention happened in A

Introduction: Drawing upon the framework of life course epidemiology, this study aligns with research on the mental health consequences of significant social transitions during early adulthood. The focus is on the variation in initial labour market attachment and the development of depressiveness, assuming that a firm attachment is associated with decreasing depressiveness. Methods: The baseline i

Background: Neonates are an extremely vulnerable patient population, with 6% to 9% admitted to the neonatal intensive care unit (NICU) following birth. Neonates admitted to the NICU will undergo multiple painful procedures per day throughout their stay. There is increasing evidence that frequent and repetitive exposure to painful stimuli is associated with poorer outcomes later in life. To date, a

Continuous water-table (WT) measurements from peatlands are scarce and – if existing at all –very short. Consequently, proxy indicators are critically needed to simulate hydrological changes in peatlands over longer time periods. In this study, we demonstrate that tree-ring width (TRW) records of Scots pine (Pinus sylvestris L.) growing in the Čepkeliai peatland (southern Lithuania) can be used as

Approximately 20% of the population experience long-term pain. Women are generally more affected than men. Currently, pain researchers advocate a biopsychosocial perspective, which emphasises the importance of addressing psychological and social factors as well as biomedical ones in clinical practice. However, previous research shows that this holistic perspective is not always materialized in med

Aim: This study investigates the effect of time and age on health-related quality of life, general self-efficacy, and functional level 12 months following dysvascular major lower limb amputation (LLA). Methods: A prospective cohort study design with assessments at baseline and follow-up 3, 6, and 12 months post-amputation. Data were collected via in-person interviews using Short Form 36, the Gener

Soil microbes play an important role in governing global processes such as carbon cycling, but it is challenging to study them embedded in their natural environment and at the single cell level due to the opaque nature of the soil. Nonetheless, progress has been achieved in recent years towards visualizing microbial activities and organo-mineral interaction at the pore scale, especially thanks to

BACKGROUND: ATOR-1017 (evunzekibart) is a human agonistic immunoglobulin G4 antibody targeting the costimulatory receptor 4-1BB (CD137). ATOR-1017 activates T cells and natural killer cells in the tumor environment, leading to immune-mediated tumor cell death.METHODS: In this first-in-human, multicenter, phase I study, ATOR-1017 was administered intravenously every 21 days as a monotherapy to pati