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In biomarker analysis, sample preparation plays a crucial step in order to extract, isolate and concentrate the analytes of interest. Among the various sample preparation techniques, solid phase extraction (SPE) is one of the most common and popular, due to the high enrichment factor, good recovery, low consumption of organic solvents and the possibility to automate (off- or on-line) the whole pro
Personal data is found at the core of the digital economy, and from a consumer perspective it is increasingly difficult to assess when it's collected, how it is utilised or traded and by what third parties it is handled over time. As Rhoen (2016) argues, a broader application of consumer protection regulation to user agreements may increase accountability for operators who collect and manage perso
OBJECTIVE: To explore and quantify the relative strengths of the genetic contribution vs the contribution of modifiable environmental factors to severe osteoarthritis (OA) having progressed to total joint arthroplasty.DESIGN: Incident data from the Norwegian Arthroplasty Registry were linked with the Norwegian Twin Registry on the National ID-number in 2014 in a population-based prospective cohort
In this article, we deal with the so-called "risky sexual behaviours" and the spread of HIV/AIDS among the community of MSM (men who have sex with other men). For a long time, both the sociological analysis and the medical and epidemiological approach studied the behaviour of the gay population as “inherently” more problematic in terms of spreading the human immunodeficiency virus. For these studi
This paper uses international health expenditure and the latest OECD data to investigate the determinants of aggregate health expenditure. The study differs from most previous studies in two principal ways. First, it uses a somewhat larger sample for estimation, with pooled time-series, cross-section data for 22 OECD countries for a 20-year period. Most previous work has used a purely cross-sectio
Background: It remains unknown if bivalirudin compared to heparin confers any additional inhibition of platelet and coagulation activation during primary percutaneous coronary intervention (PPCI) after pretreatment with ticagrelor. Methods: In this substudy of VALIDATE-SWEDEHEART trial, 103 patients pretreated with ticagrelor were randomized before PPCI to heparin or bivalirudin. Blood samples wer
Magnetomotive ultrasound is an emerging technique that enables detection of magnetic nanoparticles. This has implications for ultrasound molecular imaging, and potentially addresses clinical needs regarding determination of metastatic infiltration of the lymphatic system. Contrast is achieved by a time-varying magnetic field that sets nanoparticle-laden regions in motion. This motion is governed b
Aim: To evaluate the long-term success rate of treatment with the Surgisis® (Biodesign®) anal fistula plug for complex anal fistulas, assess fistula plug failure over time and compare success rates for fistula plug between a group of patients with cryptoglandular fistula and another group with Crohn's fistula. Method: This is a single-centre study of consecutive patients treated with the Surgisis®
Purpose: The purpose of this paper is to review the Russian Federation Government Quality Award (RFGQA) over its 25-year existence. Design/methodology/approach: This paper looks into the evolution, model and key provisions of RFGQA, based on the authors’ long-time experience as an Award assessor. Apart from that, methodologically, this study uses the desktop research method, comparative literature
Smartphones have become one of the main tools for travel information search, especially on site, during the trip. The use of mobile technologies and ubiquitous internet connectivity do not only allow tourists to access information anywhere, at any time, but have deep impacts on tourists’ behaviours and on their whole tourist experience.The study suggests an interpretation of tourists’ information
BACKGROUND: Continued professional development (CPD) is required for updated skills and knowledge. This study evaluates the efficacy of a CPD programme for mainstream school teachers.AIMS: In an 11-week intervention programme, speech-language therapists (SLTs) presented the participating teachers with whole-class teaching techniques aimed at creating a language and communication-supporting classro
Warming in the Arctic accelerates thawing of permafrost-affected soils, which leads to a release of greenhouse gases to the atmosphere. We do not know whether permafrost thaw also releases non-methane volatile organic compounds that can contribute to both negative and positive radiative forcing on climate. Here we show using proton transfer reaction–time of flight–mass spectrometry that substantia
Cirka 1000 barn föds med hjärtfel i Sverige varje år och idag överlever de flesta och uppnår vuxen ålder. Det finns uppskattningsvis 2.3 miljoner vuxna med medfött hjärtfel i Europa idag, en siffra som förväntas öka. Samtidigt har prevalensen av patienter med komplexa medfödda hjärtfel också ökat de senaste 10 åren. Det finns således ett behov av att öka kunskapen om patofysiologin vid dessa sjukdAround 1000 children are born with a heart disease in Sweden every year and today most of these children survive and reach adult age. There are around 2.3 million grownups with congenital heart disease in Europe today, a number that is expected to continue to increase. Further, the prevalence of patients with complex malformations has been growing significantly the last 10 years. There is thus a n
The purpose was to examine the association between exercise during pregnancy and intelligence score in offspring. We analyzed data from 4008 women from the Aarhus Birth Cohort, Aarhus University Hospital, Denmark, recruited during pregnancy from July 1989 to November 1991 and their sons who were registered at conscription at 17-20 years of age. The women gave information by self-administered quest
Since the 1990s, social work has been subject to requirements for monitoring and quality assurance. Here we examine one of the monitoring systems: Open Comparisons (OC). Gradually expanded and published online by a national agency, the OC now has around 350 indicators that cover major areas within social work in Sweden. We use program theory to clarify the operational idea in which OC is based. To
In partially premixed combustion engines high octane number fuels are injected into the cylinder during the late part of the compression cycle, giving the fuel and oxidizer enough time to mix into a desirable stratified mixture. If ignited by auto-ignition such a gas composition can react in a combustion mode dominated by ignition wave propagation. 3D-CFD modeling of such a combustion mode is chal
Realistic depictions of past land cover are needed to investigate prehistoric environmental changes, effects of anthropogenic deforestation, and long-term land cover-climate feedbacks. Observation-based reconstructions of past land cover are rare, and commonly used model-based reconstructions exhibit considerable differences. Recently, Pirzamanbein et al. (2018, 10.1016/j.spasta.2018.03.005, Spati
Over the last few decades, the African Sahel has become thefocus of many studies regarding vegetation dynamics and theirrelationships with climate and people. This is because rainfalllimits the production of biomass in the region, a resource onwhich people are directly dependent for their livelihoods. In thisstudy, we utilized a remote-sensing approach to answering thefollowing two questions: (1)
Background and objectives: This cross-sectional, epidemiological study sought to assess the prevalence and extent of potential risk factors for hypertension, particularly renal function related to haematuria and their associations in people with haemophilia. Methodology: Demographic and medical data were collected at a single time-point in patients with haemophilia over 40 years of age from 16 Eur
Hepatocellular carcinoma (HCC), the third major cause of cancer mortality, can result from non-alcoholic steatohepatitis (NASH). Due to limited efficacy of drugs approved for HCC and no drug available yet for NASH, identification of new effective treatments is crucial. Here, we investigated whether NV556, a cyclophilin inhibitor derived from sanglifehrins, would decrease the development of NASH an
