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Background and objectives: This cross-sectional, epidemiological study sought to assess the prevalence and extent of potential risk factors for hypertension, particularly renal function related to haematuria and their associations in people with haemophilia. Methodology: Demographic and medical data were collected at a single time-point in patients with haemophilia over 40 years of age from 16 Eur
Timely detection and surveillance of disease community spread is a potent tool for implementing effective public health interventions. This study investigates the National Telehealth Service (1177 helpline) across 18 regions in Sweden in 2020 to identify early signals of community transmission of COVID-19 at the beginning of the pandemic. Focusing on calls related to key COVID-19 symptoms (cough,
BACKGROUND AND AIM: Hepatorenal syndrome (HRS) occurs in about 20 % of patients with liver cirrhosis and ascites and is characterized by intensive renal vasoconstriction, low glomerular filtration rate but preserved tubular function and normal renal histology. The potential of terlipressin and albumin to reverse HRS after a time period of 14 days has already been shown. However, intravenous albumi
OBJECTIVE: To explore and quantify the relative strengths of the genetic contribution vs the contribution of modifiable environmental factors to severe osteoarthritis (OA) having progressed to total joint arthroplasty.DESIGN: Incident data from the Norwegian Arthroplasty Registry were linked with the Norwegian Twin Registry on the National ID-number in 2014 in a population-based prospective cohort
This is the story of how a large research facility of broad European and global interest, the European Spallation Source (ESS), ended up in the small university town of Lund in Sweden. This happened in spite of the fact that a number of influential European countries were at one time or another competitors to host the facility. It is also a story about politics which attempts to illustrate how clo
Avian haemosporidian parasites are globally widespread with a broad repertoire of hosts. When infected, the host can either reduce (resistance) and/or limit the severity of parasitaemia (tolerance). Oxidative stress plays a pivotal role in the host's resistance and tolerance, as well as its detrimental endpoints. The rationale behind this paradox lies in the dual role of reactive oxygen species (R
During an infection, the genetic composition of the pathogen population in the host might range from clonal to genetically diverse, depending on the genetic variation of the inoculum, mutation events, genetic drift, and host selection during the course of the infection. Variation in the genetic diversity of avian malaria parasites, both within and between individual hosts, is not well documented.
Background: Bile leakage is a severe complication after cholecystectomy and is associated with an increased risk of morbidity and mortality. The aim of this study was to evaluate the incidence of bile leakage post-cholecystectomy and to identify potential risk factors and their association with changes in the incidence of bile leakage over time. Methods: Demographic and perioperative data of all p
Inflammation Profiling in Chemotherapy One of the methods used for treating leukemia and various types of cancer is chemotherapy that is spread over multiple cycles of treatment. The chemotherapy is toxic for the blood system and severely decreased cellular output and may leave the bone marrow (BM) impaired leading to myelosuppression. Myelosuppression is a state where the BM have problems to re
PURPOSE: To assess how patients perceive health-related quality of life (HRQOL) after endovascular and open abdominal aortic aneurysm (AAA) repair. METHODS: Forty-two consecutive patients (33 men; mean age 74 years, range 46-81) were assessed prospectively before and after elective endovascular (n = 21) and open (n = 21) AAA repair. Aneurysm morphology dictated the type of repair. The two patient
Aims: To explore the incidence, severity, time course, and risk factors of clinically significant hyponatremia in desmopressin treatment for nocturia. Methods: Data from three multi-center phase 111 trials were pooled. Hyponatremia was categorised as borderline (134-130 mmol/L) or significant (<130 mmol/L). Risk factors were explored with logistic regression and subgroup analysis performed to expl
This article evaluates whether the global dispersion of ventricular repolarization (DVR) can be estimated from measurements between a few adjacent or remote sites. Monophasic action potentials (MAP) were recorded from 61 +/- 18 left (LV) or right ventricular (RV) sites in 10 pigs and 44 +/- 16 LV, or RV sites in 8 patients by using the CARTO mapping system. MAP duration (MAPd) and end-of-repolariz
Background We aimed to accurately estimate the frequency of a hexanucleotide repeat expansion in C9orf72 that has been associated with a large proportion of cases of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Methods We screened 4448 patients diagnosed with ALS (El Escorial criteria) and 1425 patients with FTD (Lund-Manchester criteria) from 17 regions worldwide for the
Popular Abstract in Swedish Att balansera. Cancer från ett primärvårdsperspektiv. Diagnostik, posttraumatisk stress och vård vid livets slut Denna avhandling belyser cancer från en utgångspunkt som kanske inte handlar om vad man först kommer att tänka på när man hör ordet cancerforskning. Det handlar inte om att “lösa cancerns gåta” eller att hitta nya metoder för behandling eller diagnos. UtgångThis thesis explores cancer from a primary care perspective covering three areas: diagnosis, posttraumatic stress disorder (PTSD), and end-of-life care. We analyzed patient records of every child diagnosed with a malignancy in a defined area. During 12 years 68 children were diagnosed (incidence 14/100,000). For 68% the diagnosis was initiated in primary care. There were 25 children with leukemia
The SM2RAIN (soil moisture to rain) model has been widely used for rainfall estimation worldwide. However, due to the lack of sufficient ground observation, the SM2RAIN model driven by different passive microwave soil moisture products over the Tibetan Plateau has not been fully validated. In this article, four widely used satellite microwave soil moisture products (including SMAP, ASCAT, SMOS, an
Dear Student, Congratulations! You have been accepted to the course SGEA23 - Human Geography: Level 2 (30 credits). We would like to wish you a warm welcome to the Department of Human Geography, Lund University. The course is taught during the period 2017-08-28 – 2018-01-14. Online registration Note! The Department of Human Geography uses online registration. This requires you as a student to regi
https://www.keg.lu.se/sites/keg.lu.se/files/welcome_letter_sgea23_fall_2017.pdf - 2026-05-05
For people with learning disabilities care in institutions has been replaced by a life in community settings e.g. group homes, where a number of persons (4-5) are living with staff support. My case-studies cover three elderly and three more lately produced such units as well as a ward in a nursing home. Data were gathered through participant observations and semistructured interviews with staff an
Atrial fibrillation (AF) is the most common form of cardiac arrhythmia encountered in clinical practice, accounting. Recent findings highlight the need for better characterisation of the arrhythmia in each patient, in order to improve patient treatment. The main objective of this work was to characterise atrial electrophysiology with respect to AF by means of non-invasively obtained data. Spectra
Resource availability and limiting factors for bacterial growth during early stages of soil development (8-138 years) were studied along a chronosequence from the glacial forefield of the Damma glacier in the Swiss Alps. We determined bacterial growth (leucine incorporation) and we investigated which resource (C, N or P) limited bacterial growth in soils formed by the retreating glacier. The latte
Continuously indexed Gaussian fields (GFs) are the most important ingredient in spatial statistical modelling and geostatistics. The specification through the covariance function gives an intuitive interpretation of the field properties. On the computational side, GFs are hampered with the big n problem, since the cost of factorizing dense matrices is cubic in the dimension. Although computational
