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Introduction: Unwanted glucose absorption during peritoneal dialysis (PD) remains a clinical challenge, especially in diabetic patients. Recent experimental data indicated that inhibitors of the sodium and glucose co-transporter (SGLT)-2 could act to reduce glucose uptake during PD, which raises the question of whether glucose absorption may also occur via intracellular or trans-cellular pathways.
Over the last decades, the field of thermal neutron detection has overwhelmingly employed He-3-based technologies. The He-3 crisis together with the forthcoming establishment of the European Spallation Source have necessitated the development of new technologies for neutron detection. Today, several promising He-3-free candidates are under detailed study and need to be validated. This validation p
We ask if mass tourism, morphing into over-tourism, can be conceptualised as an emerging plague of zombie tourists, and what kinds of tourism futures might come of it? Overtourism is not only unsustainable; it is the logical outcome of capitalism and thus, a token signifying that the capitalist system is well and alive even though it is threatening everything else on Earth. We outline a drastic na
Cloud computing has emerged as a key technology in the latest decade and continues to be applied to manage the computing needs of new domains. As a result, the requirements on predictable behavior in the cloud increase, thus the hosted applications need to be recognized as both fault-tolerant and responsive even under difficult conditions.In this thesis, new modeling methods and decision-making st
Purpose/Objective(s): Over 30% of advanced prostate cancers harbor a predominance of neuroendocrine prostate cancer (NEPC) differentiation. Fluorodeoxyglucose (FDG) positron emission tomography (PET) has numerous limitations in prostate adenocarcinoma (PCa-adeno), however there is no data that exists outside of isolated single person case reports to assess the utility of PET to restage and monitor
Many species up- or downregulate their resting metabolic rate (RMR) when they encounter favourable or unfavourable feeding conditions, respectively. This is thought to promote faster growth when food is abundant and conserve energy reserves when food is scarce. The time it takes to express metabolic plasticity remain little studied. Here, we develop a conceptual model showing how rapid or slow met
Nondisplaced or minimally displaced femoral neck fractures are commonly treated with internal fixation, because of its less invasive and less time-consuming nature, as well its retention of the biological properties of the hip. Internal fixation with screws or pins is the current clinical routine in Sweden. However, the authors of some recent studies in elderly patients have suggested that the use
The KEYNOTE-564 trial showed that adjuvant immune checkpoint inhibitor (ICI) therapy with pembrolizumab, a PD-1 antibody, significantly improved disease-free survival (DFS) and overall (OS) survival in localised clear-cell renal cell carcinoma (RCC) with a high risk of relapse. The TiNivo and CONTACT-03 trials have reported results for subsequent therapy after progression on ICI therapy in the met
Soil microorganisms are pivotal in the global carbon cycle, but the viruses that affect them and their impact on ecosystems are less understood. In this study, we explored the diversity, dynamics, and ecology of soil viruses through 379 metagenomes collected annually from 2010 to 2017. These samples spanned the seasonally thawed active layer of a permafrost thaw gradient, which included palsa, bog
Objectives: When exposed to iodine contrast medium (ICM), thyroid dysfunction may develop, due to excess amounts of iodide. The incidence of contrast-induced thyroid dysfunction has been difficult to interpret, because of the observational and retrospective designs of most previous studies. With the Swedish CArdioPulmonary bioImage Study (SCAPIS), where randomly selected individuals aged 50–65 yea
Introduction: The scapular osseous free flap (SOFF) is being increasingly used for complex head and neck reconstructions. This study examined the surgical outcomes, focusing on post-operative complications and sequelae in patients who underwent SOFF for maxillary and mandibular reconstructions. Material and Methods: This retrospective, observational, population-based study included patients who un
Objectives To follow up four previously identified classes 'pure axial spondyloarthritis' (axSpA) ('axial'), 'axSpA with peripheral signs' ('inflammatory back pain+peripheral'), 'axSpA at risk' and 'no spondyloarthritis' ('no SpA'). They reflect the expert-opinion-free construct or 'Gestalt' of chronic back pain suspicious of axSpA. The aim was to assess participants' transitions between these cla
Despite the rapid development of urban tourism, it was for a long time seen as a neglected field in tourism studies, which tended to focus on resorts and rural destinations. Cities were generally viewed as the generating, not receiving, parts of the tourist system. This lack of interest was matched by a similar disinterest of tourism in urban studies. One reason for this was the difficulty to defi
Divorce increased throughout the twentieth century across Western nations. Procyclical divorce, i.e. following macroeconomic cycles, is often suggested and women’s increased economic independence is considered a contributor to increasing divorce rates. Research has, however, overlooked that different factors may drive divorce rates across time horizons. Macroeconomic conditions, like unemployment,
The boreal forest landscape covers approximately 10% of the earth's land area and accounts for almost 30 % of the global annual terrestrial sink of carbon (C). Increased emissions due to climate-change-amplified fire frequency, size, and intensity threaten to remove elements such as C and nitrogen (N) from forest soil and vegetation at rates faster than they accumulate. This may result in large ar
OBJECTIVE: The time after birth is a crucial period for women, involving both physical recovery and emotional challenges. Previous research indicates that postnatal care is a neglected area of maternity care. The aim of this study was to explore women's suggestions for health care improvements, based on their experiences during the first year after birth.METHODS: This study is based on data from a
Simultaneous overexpression of c-erbB-2 and p53 has been reported to be prognostically unfavorable in breast cancer. Herein, we show that concurrent overexpression of these 2 proteins is associated with a marked reduction in the relative fraction of cells in G(1) phase of the cell cycle, indicating an accelerated cell cycle progression. Using an immunohistochemical approach, we examined 261 cases
Increasing evidence suggests that oral microbiota play a pivotal role in chronic diseases, in addition to the well-established role in periodontal disease. Moreover, recent studies suggest that oral bacteria may also be involved in carcinogenesis; periodontal disease has been linked to several cancers. In this study, we examined whether lifestyle factors have an impact on antibody levels to oral b
Information and Communication Technologies for education (ICT4E) have been playing an increasingly important role in schooling and training worldwide. On the one hand, they are expected to bridge various divides e.g. between developed and developing countries, urban and rural regions, affluent and poor neighborhoods etc., by spreading the most up-to-date knowledge and skills into every classroom o
