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Högsta förvaltningsdomstolen beslutade i mars 2025 att begära ett för-handsavgörande i ett mål gällande återbetalning med kupongskatt. Det ut-ländska företaget i målet menade att de inte var skyldiga att räkna ut sitt resultat enligt svenska regler, medan Skatteverket menade att det annars inte var möjligt att avgöra om det utländska företaget hade rätt till återbe-talning. Syftet med uppsatsen ärIn March of 2025, the Swedish Supreme Administrative Court decided to request a preliminary ruling in a case regarding repayment of Swedish withholding tax on dividends. The non-resident company claimed that they were not obligated to calculate their results according to Swedish rules, whereas the Swedish tax authority claimed that not doing so would make it impossible to determine whether the non

Arbetsgivarens intresse av en drogfri arbetsplats måste balanseras mot arbetstagarens rätt till personlig integritet vid drogtester, vilket skapar en komplex juridisk fråga. Uppsatsen undersöker processen stegvis för genomförandet av drogtester inom den privata sektorn ur en rättslig synvinkel. Från arbetsgivarens perspektiv granskas när och hur drogtester får utföras samt de rättsliga konsekvenThe employer’s interest in maintaining a drug-free workplace must be balanced against the employee’s right to personal integrity in the context of drug testing, creating a complex legal issue. This thesis examines the step-by-step process of conducting drug tests within the private sector from a legal perspective. From the employer’s standpoint, the study analyzes when and how drug tests may be

The object of this thesis is to analyze and discuss normcore and its discursive relationship to subculture and mainstream. The urban district Williamsburg and the French fashion brand Céline will respectively be used as cases to exemplify these two different aspects. Normcore is an attitude that the trend agency K-HOLE mapped out in their report Youth mode: A Report on Freedom. The attitude turned

Efter 2007 års lagändringar i anställningsskyddslagen anmäldes Sverige till EU-kommissionen. Anledningen var att lagens bestämmelser inte ansågs vara förenliga med direktiv 1999/70/EG om ramavtalet om visstidsarbete undertecknat av EFS, UNICE och CEEP. Enligt ramavtalet ska det finnas bestämmelser som förhindrar missbruk som uppstår av flera på varandra följande tidsbegränsade anställningar. EU-kAfter the 2007 legislative changes in the Swedish Employment Protection Act Sweden was reported to the European Commission. The reason was that its provisions were not considered compatible with Council Directive 1999/70/EC concerning the framework agreement on fixed-term work concluded by ETUC, UNICE and CEEP. According to the framework agreement, there should be measures preventing abuse arising

A FT-NIR (Fourier-Transform Near Infrared) model for moisture content has been developed for whole seeds of Swedish rapeseed (Brassica napus) by the conditions given during the harvest of 2014. Compared to Internal standardized (ISO) method 665, the final model showed very small differences in terms of repeatability and measurement uncertainty even though the measurement time was four times faster

Diffusion magnetic resonance imaging (dMRI) is a powerful non-invasive technique for probing tissuemicrostructure. While highly sensitive, conventional dMRI methods suffer from low specificity, due in part toexperimental designs that conflate multiple contrast mechanisms. This thesis aims to address these limitations bydeveloping advanced time-dependent dMRI techniques to disentangle competing sou

Objectives: Polycystic ovary syndrome (PCOS) is an endocrine disorder in women of fertile age which may also affect the labor market attachment. We investigated labor market attachment trajectories among working age women diagnosed with PCOS. Methods: A cohort of 157,356 women born in 1975–1977 were followed annually between the ages of 30 and 39, using data from Swedish administrative registers.

Clinical tools to guide treatment decisions in relapsed/refractory mantle cell lymphoma (R/R MCL) are limited. Moreover, the translational potential of circulating tumor DNA (ctDNA) remains largely unproven. We designed and applied panel-based duplex sequencing of ctDNA to study molecular determinants of response and outcome in 58 patients with R/R MCL treated with venetoclax, lenalidomide, and ri

Introduction Autistic persons experience problems with movements and body awareness in everyday functionality, expressed in affected movement quality. Yet, there is a knowledge gap about the effects of interventions targeting these aspects in autistic persons. Objective To evaluate effects of Basic Body Awareness Therapy (BBAT) and treatment-as-usual (TAU), compared to TAU alone on movement qualit

The Hunga Tonga eruption on 15 January 2022 (HT-22) induced vigorous volcano–sea interaction. Here we study the stratospheric aerosol and water vapor resulting from the eruption using satellite-based instruments: the CALIOP lidar and the Microwave Limb Sounder (MLS). We investigate the stratospheric relative humidity following the record-breaking water vapor injections from the HT-22 eruption and

A humoral immune response against aberrant tumor proteins can be elicited in cancer patients, resulting in the production of auto-antibodies (Abs). By serological proteome analysis we identified the surface membrane protein ADAM10, a metalloproteinase that has a role in epithelial-tumor progression and invasion, as a target of the immune response in colorectal cancer (Crc). A screening carried out

To determine the epidemiology and outcome of children with Down syndrome (DS) diagnosed with acute leukaemia in the Nordic countries, data registered in the Nordic Society of Paediatric Haematology and Oncology (NOPHO) population-based leukaemia registry were analysed. Of 3494 children with acute leukaemia diagnosed between July 1984 and December 2001, 136 patients (3.9%) with DS were identified.

Purpose To analyse the consequences of using different radiographic measurements and different threshold values for hip screening in children with cerebral palsy (CP). Methods In a total sample of children with CP a standardised radiological follow-up of the hips was carried out as a part of a hip prevention programme. Acetabular index (AI) and migration percentage (MP) were measured on all radiog

The mitochondrial protein frataxin plays a central role in mitochondrial iron homeostasis, and frataxin deficiency is responsible for Friedreich ataxia, a neurodegenerative and cardiac disease that affects 1 in 40000 children. Here we present a single-particle reconstruction from cryoelectron microscopic images of iron-loaded 24-subunit oligomeric frataxin particles at 13 and 17 angstrom resolutio

Cladribine has single-drug activity in acute myeloid leukaemia (AML), and may enhance the formation of the active metabolite (ara-CTP) of cytosine arabinoside (ara-C). To evaluate the feasibility of adding intermittent cladribine to intermediate-dose ara-C (1 g/m(2)/2 h) b.i.d. for 4 d with idarubicin (CCI), we performed a 2:1 randomized phase II trial in AML patients aged over 60 years. Primary e

Stimulation around the superior cerebellar peduncle or within the deep cerebellar nuclei is known to inhibit the inferior olive with a very long latency. It has been suggested that this inhibition is mediated by the GABA-ergic nucleo-olivary pathway, but alternative explanations such as activation of an indirect excitatory pathway or a pathway via the red nucleus are possible. A long-latency inhib

The endothelin B2 (ETB2) receptors are induced in vascular smooth muscle cells (VSMCs) in cardiovascular diseases. We tested if in vitro short-term exposure to the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) could up-regulate ETB2 receptors in rat mesenteric arteries, and if this effect is through activation of intracellular nuclear factor-kappa B (NF-kappa B) pathway. The me

The discoidin domain receptors, (DDR) 1 and DDR2, have been linked to numerous human cancers. We sought to determine expression levels of DDRs in human lung cancer, investigate prognostic determinates, and determine the prevalence of recently reported mutations in these receptor tyrosine kinases. Tumour samples from 146 non-small cell lung carcinoma (NSCLC) patients were analysed for relative expr

Nitric oxide (NO) is an important signalling molecule that has been suggested to be a key molecule for induction and maintenance of migraine attacks based on clinical studies, animal experimental studies and the expression of nitric oxide synthase (NOS) immuno reactivity within the trigeminovascular system. Sensitisation of the trigeminal system including the trigeminal ganglia neurones is believe