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Background/objectives: Patients with Alzheimer’s disease (AD) are at present treated with galantamine without actual knowledge of plasma concentration levels. The aim of this presentation is to analyse the relationship between galantamine plasma concentration, dose, demographics and body mass index (BMI). Methods: A total of 84 AD patients recruited at the Memory Clinic in Malmö, Sweden, treated w

Aim. This paper reports a study investigating quality of life in relation to loneliness, caregiving, social network, gender, age and economic status among caregiving men and women in a population-based sample aged 75 years or older.Background. Because of demographic changes, in the future more care for older people will be given by informal caregivers who are themselves older. Being old and caring

In 1997-2003, a protocol for treatment of acute myeloid leukaemia (AML) (except promyelocytic leukaemia) was activated in four Swedish health care regions covering 50% of the national population. Based on cytogenetics and clinical findings, patients aged 18-60 yr were assigned to one of three risk groups. In this report we account for the long-term clinical outcome of enrolled patients. Patients r

We aim to provide a long-term ecological analysis of land-use and floristic diversity in the transition from traditional to modern land-use management in the time a.d. 1800-2008 in southern Sweden. We use the Regional Estimates of Vegetation Abundance from Large Sites (REVEALS) model to quantify land-cover changes on a regional scale at 20-year intervals, based on the fossil pollen record. Florist

Objectives: To characterize intraocular pressure (IOP) changes during 6 years of follow-up among patients with early, newly diagnosed glaucoma randomized to no initial treatment in the Early Manifest Glaucoma Trial (control group) and to evaluate factors associated with IOP changes in this group. Methods: Early Manifest Glaucoma Trial control patients, aged 50 to 80 years at baseline, were followe

Both glial cell line-derived neurotrophic factor (GDNF) and its recently discovered congener, neurturin (NTN), have been shown to exert neuroprotective effects on lesioned nigral dopamine (DA) neurons when administered at the level of the substantia nigra. In the present study, we have explored the relative in vivo potency of these two neurotrophic factors using two alternative routes of administr

High blood pressure (BP) is associated with cardiovascular morbidity and mortality. Both genetic and environmental factors are implicated in BP homeostatsis and hypertension development. The aims of the present theisis were: (a) to test if ambulatory BP (ABP) is better than office BP (OBP) to capture the heritable part of BP and if BP variability (BPV) measured by ABP monitoring is a heritable tra

The university programmes are basically nationally based, developed from the historical needs of specific need of a society. The Bologna process is challenging the educational market mainly at post-graduate level. The exchange of students is still limited to a reduced number of curious and ambitious persons, many with a high interest for cultural exchange – the ‘exotic dimension’. Individual caree

Objective. To study the clinical recovery from acute otitis media ( AOM) in children, 2-16 years of age, managed with or without treatment with phenoxymethylpenicillin ( PcV). Design. An open, prospective randomized trial. Children aged between 2 and 16 years, presenting with one- or double-sided AOM ( without perforation) with symptom duration of less than four days, were included. The children w

Objective: To evaluate the safety and endometrial protection of low-dose transdermal estradiol (E2)/norethisterone acetate (NETA) patches (Estalis 25/125) in terms of post-treatment incidence of endornetrial hyperplasia/cancer after 1 year of treatment in postmenopausal women with intact uteri. Methods: Patients were randomized to receive either transdermal E2/NETA (delivering daily doses of E2 25

Coping with cold winter conditions is a major challenge for many insects.In early spring we observed newly emerged Drosophila subobscura, which had overwintered as larvae and pupae. As temperatures increase during spring these flies are faced with higher minimum and maximum temperatures in their natural microhabitat. Thus, there is a potential costly mismatch between winter and early spring acclim

Studies of the structural dynamics of solids can improve our understanding of atomic motion in materials, and may thus help in the manufacture of new devices or the development of materials with novel structures and properties. Ultrashort laser pulses, a few tens of femtoseconds long, can deliver high energies (mJ–kJ). This energy is absorbed by the electrons in a solid material, leading to a rapi

Popular Abstract in Swedish Intensifieringen av jordbruket under de senaste sextio åren har resulterat i en dramatisk produktionsökning av framförallt spannmål. Denna typ av produktion, speciellt det mest intensiva s.k. industrijordbruket, har samtidigt också resulterat i en ohållbar degradering av ekosystemen och miljön, till exempel förlust av biologisk mångfald, utsläpp av växthusgaser, förgiftSeveral studies have found that organic farms support higher biodiversity, but results vary between studies such that some also show no or even negative effects. There can be many reasons why studies comparing organic and conventional farming show conflicting results. The efficacy of organic farming can depend on focal taxa, landscape context, study scale and the proportion of organically managed

Objectives. To investigate metabolic features that may predispose to GCA in a nested case-control study. Methods. Individuals who developed GCA after inclusion in a population-based health survey (the Malmö Preventive Medicine Project; N ¼ 33 346) were identified and validated through a structured review of medical records. Four controls for every validated case were selected from the database. Re

Vegetation responds to drought through a complex interplay of plant hydraulic mechanisms, posing challenges for model development and parameterization. We present a mathematical model that describes the dynamics of leaf water-potential over time while considering different strategies by which plant species regulate their water-potentials. The model has two parameters: the parameter λ describing th

Multiple-pilot injection strategies with both moderate and short time separations (dwells) are investigated in a light-duty diesel engine. Both conventional and optical engine experiments are performed. By implementing triple-pilot injection strategies with short dwells between the individual injections, combustion noise can be significantly reduced. The sound pressure level was reduced by nearly

Popular Abstract in Swedish I Big Bang, då vårt Universum skapades, bildades i princip endast de två lättaste grundämnena, väte och helium. Alla andra grundämnen har skapats, och skapas fortfarande, i olika typer av stjärnor under olika utvecklingsfaser. Detta betyder att precis alla atomer, förutom väte och helium, som bygger upp alla saker, växter, djur och människor i vår omgivning, har bildatsDisregarding the small primordial traces of the lightest elements, all metals have been formed in stellar processes, which means that the relative amount of metals in the Universe increases for every stellar generation. This build-up of elements is called chemical evolution and might be used both to constrain stellar models as well as understanding the formation and evolution of stellar population

The tradition of writing books specifically for girls came to an abrupt end in the middle of the 1960's. In Sweden this was a turbulent decade when society changed in many ways, and equality between the sexes was a key word. The old girls' and boys' books were replaced by "the modern book for young people", which, it was proclaimed, should be up-to-date, discuss real problems, break taboos, and ap

For many multivariable problems there are no efficient algorithms for finding solutions. To this day, conventional electronic computers mainly solve problems in a sequential manner. This sequential operation prevents problem-solving within a reasonable time-frame due to superpolynomial, and sometimes even exponential, time complexities. Developing powerful parallel computation techniques has there

OBJECTIVE: This longitudinal study examines a possible causal effect between type 2 diabetes and ischemic heart disease (IHD) by using measurements on four occasions from the Swedish Statistics on Income and Living Conditions (SILC) together with nationwide healthcare registers.METHODS: This was a longitudinal study based on a random sample of men and women (n = 2014) from the Swedish population w