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Genomic gain of the proto-oncogene transcription factor gene MYCN is associated with poor prognosis in several childhood cancers. Here we present a comprehensive copy number analysis of MYCN in Wilms tumour (WT), demonstrating that gain of this gene is associated with anaplasia and with poorer relapse-free and overall survival, independent of histology. Using whole exome and gene-specific sequenci
Our purpose with this paper was to examine the school and class situation in form nine from the pupils' own perspective, and their thoughts about ending comprehensive school. The main questions were: How do pupils in form nine describe the best vs. worst about school? How do pupils in form nine describe the relations in their class? How do pupils in form nine describe their own role/position i
Den 1 januari 2009 slopades avskattningsregeln för personaloptioner till förmån för en regel anpassad till EU-praxis. Avskattningsregeln reglerade anställda som deltagit i personaloptionsprogram och som flyttat ut ur Sverige innan programmet löpt ut. Avskattningsregeln träffade den del av personaloptionen för vilken kvalifikationstidpunkten infallit under tid då den anställde haft sitt hemvist iOn January the first 2009 the rule of exit taxation for stock-options was abolished in favor of a rule adapted to EU case law. The rule of exit taxation regulated employees who participated in stock option plans and who moved out of Sweden before those plans had expired. The rule of exit taxation was aimed at those stock options for which vesting had occurred during the period when the employee r
Popular Abstract in Swedish Samarbete är ett värdeladdat ord i svenskt välfärdsarbete och inom socialt arbete förespråkas samarbete ofta som något värdefullt och nödvändigt. Idag finns det en stor, om än fragmenterad, vardagskunskap om samarbete och samverkan. Vetandet präglas dock av ett okritiskt accepterande av samarbetets fördelar, samtidigt som många verksamheter visar att resultaten av samarCo-operation is highly valued in Swedish welfare work and joint efforts within and between healthcare and welfare organizations is not new in Sweden. For decades the authorities have been trying to organize and coordinate various social and medical efforts in the public sector at a central level. This thesis is focusing on the meaning of co-operation between professionals belonging to different or
Problem: Suspected, but objectively absent, rhinosinusitis constitutes a major cause of visits to the doctor, high health care costs, and the over-prescription of antibiotics, contributing to the serious problem of resistant bacteria. This situation is largely due to a lack of reliable and widely applicable diagnostic methods. Method: A novel method for the diagnosis of rhinosinusitis based on non
The aim of this work is the development of a thermodynamically consistent fully coupled thermo-viscoplastic material model for metals undergoing finite deformations. A multiplicative split of the deformation gradient into a thermal, an elastic and a plastic part is introduced, where isotropic thermal expansion and isochoric plastic deformation are assumed. The model is based on a decomposition of
Objectives: To determine predictors of renal relapse and end-stage renal failure (ESRF) in patients with ANCA-associated vasculitis. Methods: Data from four European Vasculitis Society randomized controlled trials, conducted roughly simultaneously between 15 March 1995 and 30 September 2002, was pooled to determine predictors of long-term renal outcome. The respective trial inclusion criteria cove
In the sporadic permafrost zone of North America, thaw‐induced boreal forest loss is leading to permafrost‐free wetland expansion. These land cover changes alter landscape‐scale surface properties with potentially large, however, still unknown impacts on regional climates. In this study, we combine nested eddy covariance flux tower measurements with satellite remote sensing to characterize the imp
Immunosensors made with nanostructured films are promising for detecting cancer biomarkers, even at early stages of the disease, but this requires control of film architecture to preserve the biological activity of immobilized antibodies. In this study, we used electrochemical impedance spectroscopy (EIS) to detect Prostate Specific Antigen (PSA) with immunosensors produced with layer-by-layer (L
Ultrafast photoexcitation can generate internal compressive stress in Mott insulators that lead to strain waves from free surfaces. These photoinduced elastic waves can trigger phase transitions in materials. However, a comprehensive physical picture of the phase transformation dynamics that includes acoustic-scale propagation has not yet been developed. Here we demonstrate that such a strain-wave
Biochemical differences between sexes can also be seen in non-sexual organs and may affect organ functions and susceptibility to diseases. It has been shown that there are sex-biased visual perceptions and impairments. Abundance differences of eye proteins could provide explanations for some of these. Exploration of the ocular proteome was performed to find sex-based protein abundance differences
Animal eyes typically possess specialized regions for guiding different behavioural tasks within their specific visual habitat. These specializations, and evolutionary changes to them, can be crucial for understanding an animal's ecology. Here, we explore how the visual systems of some of the smallest flying insects, fungus gnats, have adapted to different types of forest habitat over time (approx
Objective: IgG antibodies against apolipoprotein A-I (ApoA-I) have been found to be elevated in subjects from the general population with clinically manifest cardiovascular disease and in myocardial infarction patients with an adverse prognosis. Here, we investigated whether these antibodies are prospectively associated with carotid artery disease progression and with the risk for first-time cardi
Nutritional stability – a food system’s capacity to provide sufficient nutrients despite disturbance – is an important, yet challenging to measure outcome of diversified agriculture. Using 55 years of data across 184 countries, we assemble 22,000 bipartite crop-nutrient networks to quantify nutritional stability by simulating crop and nutrient loss in a country, and assess its relationship to crop
We have studied whether calculations of the binding free energy of small ligands to a protein by the MM/GBSA approach (molecular mechanics combined with generalized Born and surface area solvation) can be sped up by including only a restricted number of atoms close to the ligand. If the protein is truncated before the molecular dynamics (MD) simulations, quite large changes are observed for the ca
Objective: Needle acupuncture in small children has gained some acceptance in Western medicine. It is controversial, as infants and toddlers are unable to consent to treatment. We aimed to assess its efficacy for treating infantile colic. Design: A systematic review and a blinding-test validation based on individual patient data from randomised controlled trials. Primary end-points were crying tim
The utility of mRNA and protein determinations of G protein-coupled receptor 35, that is, GPR35a (GPR35 V1) and GPR35b (GPR35 V2/3), as indicators of outcome for colon cancer patients after curative surgery was investigated. Expression levels of V1 and V2/3 GPR35, carcinoembryonic antigen and CXCL17 mRNAs were assessed in primary tumours and regional lymph nodes of 121 colon cancer patients (stage
Phytantriol Q224 cubic phase, as a bicontinuous meso-structured material stable in contact with aqueous electrolyte, has found applications in drug delivery and cosmetics and is employed here as a free-standing film separating two aqueous compartments in order to study i) ion conductivity (at low potential bias within ±0.8 V), ii) conductivity switching effects (at high potential bias beyond ±0.8
