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Abstract in Danish Kapitlet sætter fokus på, hvordan sygeplejestuderende kan udvikle professionelle kompetencer i den kliniske del af sygeplejerskeuddannelsen. Indledningsvis reflekteres over kompetencebegrebet knyttet til professionsbacheloruddannelsen, og begrebet læring defineres som henholdsvis erhvervelse og deltagelse. Erhvervelse som læringstilgang er den mest dominerende forståelse af læri

Discrete Methods used in Graph Theory and Linear Programming

The content of the thesis is divided into two parts; graph theory and linear programming. The main results in the first part concerns extremal graph theory. Here we want to determine the number of edges in a graph needed to ensure the existence of certain local structures. Upper and lower bounds are given for the number of edges in a graph to ensure triangles and quadrilaterals respectively, when

Balance in single-limb stance after surgically treated ankle fractures: a 14-month follow-up

Background: The maintenance of postural control is fundamental for different types of physical activity. This can be measured by having subjects stand on one leg on a force plate. Many studies assessing standing balance have previously been carried out in patients with ankle ligament injuries but not in patients with ankle fractures. The aim of this study was to evaluate whether patients operated

Flow cytometric DNA ploidy and number of cell populations in the primary breast cancer and their correlation to the prognosis.

In a prospective study on 516 breast cancer patients flow cytometry DNA ploidy and number of cell populations (defined as number of DNA stem lines) detected in the primary tumor were evaluated for prognostic purposes. the median follow-up time was about 5 years. in the 241 node negative cases, those patients with three or more cell populations had the worst prognosis, with a distant recurrence-fre

Dynamic response of a constrained axially loaded beam

A dynamic beam system loaded harmonically in the axial direction and constrained in the transverse direction is modelled using different theoretical descriptions. Results from an experimental set-up are compared to calculations using Bernoulli as well as Timoshenko beam theories. Some results from investigations of this beam system unveiling its chaotic nature have earlier been presented, but here

Linear Metal Chains in Ca2M2X (M = Pd, Pt; X = Al, Ge): Origin of the Pairwise Distortion and Its Role in the Structure Stability

A series of four new analogue phases Ca2M2X (M = Pd, Pt and X = Al, Ge) were prepared by direct combination of the respective elements in stoichiometric mixtures at high temperature in order to analyze the impact of valence electron count (vec) and electronegativity differences (Delta chi) on the structure selection and stability. Their crystal structures, as determined from single-crystal X-ray d

Smoking Predicts Incident Fractures in Elderly Men: Mr OS Sweden

The aim of this study was to investigate the association between smoking and bone mineral density (BMD) and radiographically verified prevalent vertebral fractures and incident fractures in elderly men. At baseline 3003 men aged 69 to 80 years of age from the Swedish Mr Os Study completed a standard questionnaire concerning smoking habits and had BMD of the hip and spine measured using dual-energy

Genetic factors related to racial variation in plasma levels of insulin-like growth factor-1: implications for premenopausal breast cancer risk

The oral contraceptive pill is associated with a modest increase in the risk of early-onset breast cancer in the general population, but it is possible that the risk is higher in certain subgroups of women. The relative risk of breast cancer associated with oral contraceptive use has been reported to be higher for African-American women than for white women. African-American women also have a high

Reduced training is associated with increased loss of BMD.

This 8-year controlled, follow-up study in 66 Swedish soccer women evaluated the effect of training and reduced training on BMD. The players who retired during the follow-up lost BMD in the femoral neck, whereas the controls did not. Introduction: Physical activity during adolescence increases BMD, but whether the benefits are retained with reduced activity is controversial. Materials and Method

Selective recovery of lactate dehydrogenase using affinity foam.

Selective isolation of lactate dehydrogenase (LDH) from porcine muscle extract was studied using foam generated from the vigorous stirring of a non-ionic surfactant, Triton X-114 derivatized with Cibacron blue. The cloud point of the surfactant-dye conjugate was higher than that of the native Triton X-114, and also the foam prepared from the affinity surfactant was more rigid taking a longer time

Coffee and tea consumption, genotype- based CYP1A2 and NAT2 activity and colorectal cancer risk- Results from the EPIC cohort study

Coffee and tea contain numerous antimutagenic and antioxidant components and high levels of caffeine that may protect against colorectal cancer (CRC). We investigated the association between coffee and tea consumption and CRC risk and studied potential effect modification by CYP1A2 and NAT2 genotypes, enzymes involved in the metabolization of caffeine. Data from 477,071 participants (70.2% female)

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

Background Olaparib, a novel, orally active poly(ADP-ribose) polymerase (PARP) inhibitor, induced synthetic lethality in BRCA-deficient cells. A maximum tolerated dose and initial signal of efficacy in BRCA-deficient ovarian cancers have been reported. We therefore assessed the efficacy, safety, and tolerability of olaparib alone in women with BRCA1 or BRCA2 mutations and advanced breast cancer. M

Comorbidities and Mortality in Bipolar Disorder A Swedish National Cohort Study

IMPORTANCE Bipolar disorder is associated with premature mortality, but the specific causes and underlying pathways are unclear. OBJECTIVE To examine the physical health effects of bipolar disorder using outpatient and inpatient data for a national population. DESIGN, SETTING, AND PARTICIPANTS National cohort study of 6 587 036 Swedish adults, including 6618 with bipolar disorder. MAIN OUTCOMES AN

Assessment of learning powered mobility use-Applying grounded theory to occupational performance.

Collaboration by two grounded theory researchers, who each had developed a learning continuum instrument, led to the emergence of a new tool for assessment of learning powered mobility use. We undertook a rigorous process of comparative reanalysis that included merging, modifying, and expanding our previous research findings. A new instrument together with its facilitating strategies emerged in th

Clinical Impact of Second-Generation Everolimus-Eluting Stent Compared With First-Generation Drug-Eluting Stents in Diabetes Mellitus Patients Insights From a Nationwide Coronary Intervention Register

Objectives This study sought to study the second-generation everolimus-eluting stent (EES) as compared with first-generation sirolimus-eluting (SES) and paclitaxel-eluting stents (PES) in diabetes mellitus (DM) patients. Background There are limited data available comparing clinical outcomes in this setting with EES and SES, whereas studies comparing EES with PES are not powered for low-frequency

Epileptogenesis induced by rapidly recurring seizures in genetically fast- but not slow-kindling rats

A brief period of rapidly recurring hippocampal seizures can lead to the progressive development of a permanent increase of seizure susceptibility over several weeks, so-called 'delayed kindling'. We have analyzed seizure parameters critical for the induction of delayed kindling in two strains of rats characterized by fast and slow rates of traditional kindling, respectively. Forty seizures were p

Common variants in the TCF7L2 gene help to differentiate autoimmune from non-autoimmune diabetes in young (15-34 years) but not in middle-aged (40-59 years) diabetic patients.

AIMS/HYPOTHESIS: Type 1 diabetes in children is characterised by autoimmune destruction of pancreatic beta cells and the presence of certain risk genotypes. In adults the same situation is often referred to as latent autoimmune diabetes in adults (LADA). We tested whether genetic markers associated with type 1 or type 2 diabetes could help to discriminate between autoimmune and non-autoimmune diab

Spelet runt datorn: Datoranvändande som meningsskapande praktik i förskolan.

Popular Abstract in Swedish Under senare år har datorn kommit att bli ett vanligt inslag i förskolans dagliga verksamhet. Visioner och planer har formulerats, inte minst politiskt. Det har sedan varit upp till pedagogerna att organisera och genomföra datoranvändandet i den lokala förskolevardagen. Avhandlingens övergripande syfte är att studera datoranvändandets praktik i förskolan. Avsikten är däThe purpose of this thesis is to study the computer using practice within pre-school activity, or more specifically, to study aspects of meaning-making as afforded when the computer is in use in pre-school. In the study a socio-cultural perspective is used as the point of departure combined with an Ecological approach to visual perception and Positioning theory. Data was collected in three pre-sch

Seasonal changes of mechanisms maintaining clear water in a shallow lake with abundant Chara vegetation

The study is based on monitoring data on the seasonal variation during four (1996-1999) vegetation periods, as well as long-term summer data on submerged vegetation, nutrients, light, phyto-plankton and zooplankton in Lake Krankesjon, a shallow, calcium-rich, moderately eutrophic take in southern Sweden. The lake has been in the clear water state with abundant submerged vegetation since the end of