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Accurately predicting binding affinities between ligands and macromolecules has been a much sought-after goal. A tremendous amount of resources can be saved in the pharmaceutical industry through accurate binding-affinity prediction and hence correct decision-making for the drug discovery processes. Owing to the structural complexity of macromolecules, one of the issues in binding affinity predict
BACKGROUND: The use of dietary fibre in bread products is increasing because of consumer demand for healthier products. However, an increase in dietary fibre level changes the rheological properties of the dough and also the quality properties of the final bread product. In this study, effects on dough and bread staling were followed after replacing 3% of wheat flour by fibre-rich additives (fine
Purpose – In the field of humanitarianism, cluster thinking has been suggested as a solution to the lack of coordinated disaster response. Clusters for diverse functions, including sheltering, logistics and water and sanitation, can be viewed as an effort to achieve functional coordination. The purpose of this paper is to contribute to a greater understanding of the potential of cluster concepts u
This licentiate thesis focuses on clustered parametric models for estimation of line spectra, when the spectral content of a signal source is assumed to exhibit some form of grouping. Different from previous parametric approaches, which generally require explicit knowledge of the model orders, this thesis exploits sparse modeling, where the orders are implicitly chosen. For line spectra, the non-l
The aim of this study was to investigate possible changes in quality of life (QoL) in elderly persons diagnosed with cancer (65 years and above), in relation to age, contact with the health-care system, activities of daily living, hope, social network and support. The investigation points were at time of diagnosis (baseline), and again 3 and 6 months after the diagnosis. The study also aimed to in
Climate change is the biggest challenge of our time. The climate is changing dramatically because of human activity and the construction and property sector plays a key role in reducing climate emissions and building a sustainable future. Although the development of climate-smart solutions in the construction and real estate sector has come a long way, the spread of green buildings has encountered
Kort om LTH-mallen Quick guide - FUD COURSE DATABASE FOR PHD COURSES Introduction • PhD courses shall have an established course syllabus (Dnr U 2021/896). 1) • Course syllabi are submitted through FUD at: https://fukurser.lth.se/fud/ • You log in with your LU account (Lucat-ID and password). • A user is automatically assigned a Course Coordinator role based on the organisational roles registered
Background: Loss of soil organic carbon (SOC) from agricultural land is identified as one of the major threats to soils, as it influences both fertility and the production of ecosystem services from agriculture. Losses of SOC across regions are often determined by monitoring in different land use systems. Results from agricultural field experiments can reveal increasing SOC stocks after implementa
Over the last decade, serial crystallography, a method to collect complete diffraction datasets from a large number of microcrystals delivered and exposed to an X-ray beam in random orientations at room temperature, has been successfully implemented at X-ray free-electron lasers and synchrotron radiation facility beamlines. This development relies on a growing variety of sample presentation method
Globally, freshwater ecosystems are warming at unprecedented rates and northern temperate lakes are simultaneously experiencing increased runoff of humic substances (brownification), with little known consequences for future conservation of biodiversity and ecosystem functioning. We employed an outdoor mesocosm experiment during spring and summer to investigate the combined effects of gradually in
Arctic homeotherms counter challenges at high latitudes using a combination of seasonal adjustments in pelage/plumage, fat deposition and intricate thermoregulatory adaptations. However, there are still gaps in our understanding of their thermal responses to cold, particularly in Arctic birds. Here, we have studied the potential use of local heterothermy (i.e. tissue cooling that can contribute to
Giant planets form out of a disc of gas and dust – called protoplanetary disc -- that surrounded the protosun at the time of its formation. While the cores of giant planets were growing via planetesimal and pebble accretion, they started to interact with the gas in the protoplanetary disc. These interactions can lead to inward migration of all the four giant planets in our Solar System during the
BACKGROUND: Rapid diagnostic whole-genome sequencing has been explored in critically ill newborns, hoping to improve their clinical care and replace time-consuming and/or invasive diagnostic testing. A previous retrospective study in a research setting showed promising results with diagnoses in 57%, but patients were highly selected for known and likely Mendelian disorders. The aim of our prospect
Molecularly Imprinted Polymers (MIPs) are synthetic receptors capable of selective binding to their target (template) molecules and, hence, are used as recognition elements in assays and sensors as a replacement for relatively unstable enzymes and antibodies. Herein, we describe a manufacturing-friendly protocol for integration of MIP nanoparticles (nanoMIPs) with a (label-free) capacitive sensor.
The hydration of the d(CGCGAATTCGCG) B-DNA duplex in solution was studied by nuclear magnetic relaxation dispersion (NMRD) of the water nuclei 1H, 2H, and 17O, and by nuclear Overhauser effects (NOEs) in high-resolution two-dimensional 1H NMR spectra. By comparing results from the free duplex with those from its complex with netropsin, water molecules in the 'spine of hydration' in the AATT region
Level lifetime and side-feeding time measurements were performed on the excited states of the normally deformed bands of Y83 using the Doppler-shift attenuation method (DSAM). The high spin states of Y83 were populated using the fusion-evaporation reaction Ni58(S32,α3p)Y83 at 135 MeV. Twenty-two level lifetime and side-feeding times were determined in most of the cases by comparing the line shapes
To overcome soil nutrient limitation, many plants have developed complex nutrient acquisition strategies including altering root morphology, root hair formation or colonization by arbuscular mycorrhizal fungi (AMF). The interactions of these strategies and their plasticity are, however, affected by soil nutrient status throughout plant growth. Such plasticity is decisive for plant phosphorus (P) a
