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The glycosylation status of IgG has been implicated in the pathology of rheumatoid arthritis. Earlier, we reported the identification of a novel secreted endo-beta-N-acetylglucosaminidase (EndoS), secreted by Streptococcus pyogenes that specifically hydrolyzes the beta-1,4-di-N-acetylchitobiose core of the asparagine-linked glycan of human IgG. Here, we analyzed the arthritogenicity of EndoS-treat

Primary immune thrombocytopenia is an autoimmune disease associated with a reduced peripheral blood platelet count. The phenotype is variable with some patients suffering no bleeding whilst others have severe bleeding which may be fatal. Variability in clinical behaviour and treatment responses reflects its complex underlying pathophysiology. Historically the management has relied heavily on immun

Cryogels have been demonstrated to be efficient when applied for protein isolation. Owing to their macroporous structure, cryogels can also be used for treating particle-containing material, e.g. cell homogenates. Another challenging development in protein purification technology is the use of molecularly imprinted polymers (MIPs). These MIPs are robust and can be used repeatedly. The paper presen

Purpose: In patients with hemophilia B, treatment with extended half-life (EHL) recombi-nant factor IX allows for longer dosing intervals while providing equal or superior bleeding protection compared with standard half-life products. This enables flexible, individualized treatment schedules, which reduce the burden of prophylaxis and improve patient outcomes. This analysis compared the efficacy o

Schema för GEOB12 Berg- och jordartskartering, 7,5 hp, Ht2:1 2015 Kursansvariga: Per Sandgren och Anders Scherstén Lärare: MC = Mikael Calner DH = Dan Hammarlund XX = XX YY = YY AS = Anders Scherstén E-post till lärare: fornamn.efternamn@geol.lu.se Dat. Tid Moment Sal Lärare Mån 2/11 09.15-10 Introduktionsmöte Berg- och jordartskartering 206 PS, AS 10.15-12 13.15-15 15.15-16 Fö 1: Introduktion til

https://www.geologi.lu.se/sites/geologi.lu.se/files/geob12_schema_ht_2015_v3.pdf - 2026-04-27

Schema för GEOB12 Berg- och jordartskartering, 7,5 hp, Ht2:1 2015 Kursansvariga: Per Sandgren och Anders Scherstén Lärare: MC = Mikael Calner DH = Dan Hammarlund XX = XX YY = YY AS = Anders Scherstén E-post till lärare: fornamn.efternamn@geol.lu.se Dat. Tid Moment Sal Lärare Mån 2/11 09.15-10 Introduktionsmöte Berg- och jordartskartering 206 PS, AS 10.15-12 13.15-15 15.15-16 Fö 1: Introduktion til

https://www.geology.lu.se/sites/geology.lu.se/files/geob12_schema_ht_2015.pdf - 2026-04-27

Streptococcus pyogenes (group A streptococcus) causes a variety of diseases, including acute pharyngitis, impetigo, rheumatic fever and the streptococcal toxic shock syndrome. Moreover, S. pyogenes was responsible for the classical example of a nosocomial infection, the epidemics of puerperal fever (childbed fever) that caused the death of numerous women in earlier centuries. The most extensively

Disturbed haemostasis is a central finding in severe Streptococcus pyogenes infection. In particular, microthrombi are found both at the local site of infection and at distant sites. Platelets are responsible for maintaining vascular function and haemostasis. We report here that M1 protein of S. pyogenes triggers immune-mediated platelet activation and thrombus formation. M1 protein is released fr

A dry release method for fabrication of suspended nanostructures is presented. The technique has been combined with an anti-stiction treatment for fabrication of nanocantilever based nanoelectromechanical systems (NEMS). The process combines a dry release method, using a supporting layer of photoresist which is removed using oxygen ashing in a reactive ion etcher (RIE), with CHF3 plasma induced de

The nervous system is constantly infiltrated by blood-derived sentinels known as perivascular macrophages. Their immediate precursors have not yet been identified in situ and the mechanism that governs their recruitment is mostly unknown. Here, we provide evidence that CD68 (+)GR(-) monocytes can give rise to perivascular macrophages in mice suffering from endotoxemia. After adhesion to the endoth

This study demonstrates that a cytotoxic serum reactivity not requiring the presence of complement appears in the sera of patients with acute myelogenous leukemia. The reaction is detected upon short‐term incubation of sera in vitro with autochthonous mononuclear white blood cells from peripheral venous blood of patients at the acute stage of the disease. This reactivity was demonstrated in 18/18