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Objectives: To use a population pharmacokinetic approach to define maximally effective meropenem dosing recommendations for treatment of Acinetobacter baumannii and Pseudomonas aeruginosa infections in a large cohort of patients with septic shock. Methods: Adult patients with septic shock and conserved renal function, treated with meropenem, were eligible for inclusion. Seven blood samples were co
Aims In anticoagulation treatment with warfarin, the risk of thrombo-embolic events must be weighed against the risk of bleeding. Time in therapeutic range (TTR) is an important tool to assess the quality of anticoagulation treatment, and has been shown to correlate with less bleeding and thrombo-embolic complications. AuriculA, the Swedish national quality registry for atrial fibrillation and ant
Background: Despite a modest association between tobacco smoking and breast cancer risk reported by recent epidemiological studies, it is still equivocal whether smoking is causally related to breast cancer risk. Methods: We applied Mendelian randomisation (MR) to evaluate a potential causal effect of cigarette smoking on breast cancer risk. Both individual-level data as well as summary statistics
Objectives: Rituximab (RTX) is an anti-CD20 antibody that selectively depletes B cells and has emerged as a therapy for ANCA-associated vasculitis (AAV) during the past decade. This study sought to quantify and determine potential risk factors for severe infections in AAV patients treated with RTX at rheumatology clinics in Mexico City, Mexico and Lund, Sweden. Methods: The study consisted of a re
Beliefs, expectations and values are often assumed to drive decisions about climate change adaptation. We tested hypotheses based on this assumption using survey responses from 508 European forest professionals in 10 countries. We used the survey results to identify communication needs and the decision strategies at play, and to develop guidelines on adequate communications about climate change adBeliefs, expectations and values are often assumed to drive decisions about climate change adaptation. We tested hypotheses based on this assumption using survey responses from 508 European forest professionals in 10 countries. We used the survey results to identify communication needs and the decision strategies at play, and to develop guidelines on adequate communications about climate change ad
YedY from Escherichia coli is a new member of the sulfite oxidase family of molybdenum cofactor (Moco)-containing oxidoreductases. We investigated the atomic structure of the molybdenum site in YedY by X-ray absorption spectroscopy, in comparison to human sulfite oxidase (hSO) and to a MoIV model complex. The K-edge energy was indicative of MoV in YedY, in agreement with X-and Q-band electron para
Aim: To assess available evidence on the use of rFVIIa in non-orthopaedic surgery including dental surgery in adult patients with congenital haemophilia with inhibitors (PWHI). Methods: A systematic literature search was performed according to a prespecified search string; prespecified criteria were used to select applicable studies including PWHI ≥18 years of age who underwent any non-orthopaedic
Purpose: Bilateral adrenalectomy (BA) still plays an important role in the management of Cushing's disease (CD). Nelson’s syndrome (NS) is a severe complication of BA, but conflicting data on its prevalence and predicting factors have been reported. The aim of this study was to determine the prevalence of NS, and identify factors associated with its development. Data sources: Systematic literature
Purpose: To evaluate the feasibility of oral cryotherapy (OC) in children and to investigate if OC reduces the incidence of severe oral mucositis (OM), oral pain, and opioid use in children undergoing hematopoietic stem cell transplantation (HSCT). Methods: Fifty-three children, 4–17 years old, scheduled for HSCT in Sweden were included and randomized to OC or control using a computer-generated li
Background: Many inborn errors of metabolism (IEMs) may present as sudden infant death (SID). Nowadays, increasing numbers of patients with IEMs are identified pre-symptomatically by population neonatal bloodspot screening (NBS) programmes. However, some patients escape early detection because their symptoms and signs start before NBS test results become available, they even die even before the sa
Purpose: Choline is an essential nutrient for fetal and infant growth and development. Parenteral nutrition used in neonatal care lack free choline but contain small amounts of lipid-bound choline in the form of phosphatidylcholine (PC). Here, we examined the longitudinal development of serum free choline and metabolically related compounds betaine and methionine in extremely preterm infants and h
Permafrost regions contain approximately half of the carbon stored in land ecosystems and have warmed at least twice as much as any other biome. This warming has influenced vegetation activity, leading to changes in plant composition, physiology, and biomass storage in aboveground and belowground components, ultimately impacting ecosystem carbon balance. Yet, little is known about the causes and m
Recent years have seen a rise in extreme heat event (EHE)-related deaths in India. However, the impact of specific temperature thresholds on health risks remains understudied. Using Distributed Lag Non-Linear Models (DLNM), we explored the link between EHEs, defined by various temperature thresholds, and mortality risk in Ahmedabad, India, from 2002 to 2018, considering a 21-day lag. We observed a
Background and purpose — At our institution, new-borns with Barlow or Ortolani positive hips have been treated for 12 weeks with the von Rosen abduction splint until 2012 when the treatment length was halved. We inves-tigate whether acetabular development at 12 months of age and complications differ between hips treated with the von Rosen splint for 6 compared with 12 weeks. Patients and methods —
The amyloid precursor protein intracellular domain (AICD) is an intrinsically disordered regulatory segment whose conserved YENPTY motif mediates transient interactions with multiple adaptor and signaling proteins. How sequence perturbations within this motif modulate its accessibility and interaction potential within a disordered ensemble remains poorly understood. Here, we combine small-angle X-
Background: Effectively identifying individuals exposed to drug underuse, overuse and potentially inappropriate medication (PIM) in older adults is essential for minimizing preventable drug-related harms. Methods: We analysed data from 54,296 individuals aged 60–74 years from the German National Cohort (NAKO). We assessed the frequency of PIM, untreated conditions (medication and vaccination under
Summer Elective CLINICAL TRIALS Module code MDCS42300 Duration 7 weeks Schedule Full-Time online Next intake June 2021 UCD School of Medicine UCD Clinical Research Centre HOW WILL I LEARN? To complete the Clinical Trials module you will » Participate in 7 weeks of Study » Earn 10 ECTS credits » Complete 7 different units » Successfully pass all assessments and examinations » Unit 1 - 14 June » Uni
https://www.student.med.lu.se/sites/student.med.lu.se/files/2021-05/ucd-summer-elective-clinical-trials-brochure.pdf - 2026-06-28
SGEM20_2017_Schedule – 1 – Human Geography SGEM20 GEOGRAPHICAL THOUGHT Autumn 2017 SCHEDULE Day: Time: Room: Lecturer: Title: 28 Aug. 14:15 – 16 Rio HGL 1. Making geography 1 30 Aug. 13:15 – 15 Malmö HGL 2. Making geography 2 / Regional geography 1 1 Sep. 13:15 – 15 Malmö HGL 3. Regional geography 2 / Spatial science 1 4 Sep 13:15 – 15 Malmö HGL 4. Spatial science 2 / Humanistic geography 1 6 Sep
https://www.keg.lu.se/sites/keg.lu.se/files/sgem20_schedule_ht17.pdf - 2026-06-28
Schema SGE 110:3 Näringsliv och samhälle: ett globalt perspektiv Schedule SGEM23: Urban and Regional Planning for Sustainability Spring term 2018 – Preliminary Schedule Room: 111 = Världen, 1st floor Rio = 4th floor Day Time Moment Lecturer Room Mo 15.1 13-14 Introduction to the course MG Rio Mo 15.1 14-16 Economic, Social and Territorial Cohesion – in what sense sustainable? A European perspectiv
https://www.keg.lu.se/sites/keg.lu.se/files/sgem23_schedule_spring_18.pdf - 2026-06-28
Schedule SGED12, fall-2018 Geography of African Development II Course Convenor: Yahia Mahmoud Teachers: Magnus Jirström (MJ) Yahia Mahmoud (YM) PRELIMINARY SCHEDULE Date/time Venue Topic Lecturer Nov. 5 10-11 Rio Course introduction YM Nov. 6 10-12 Rio Current research in Africa YM Nov. 8 10-12 Rio Doing research in Africa YM Nov. 9 10-12 Rio Data collection and data availability in the African co
https://www.keg.lu.se/sites/keg.lu.se/files/sged12_schedule_fall_2018.pdf - 2026-06-28
