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We investigate vascular changes during Photodynamic therapy (PDT) of skin tumors using optical Doppler tomography (ODT). The effect of vascular shut down on tumor destruction is currently not known, and to optimize treatment it is relevant to investigate this issue further. Optical Doppler tomography is capable of measuring blood flow in biological tissue down to 1-2 mm with sub-mm/s velocity sens

Integrated models including optics, structures, control systems, and disturbances are important design tools for Extremely Large Telescopes (ELTs). An integrated model has keen formulated for the European ELT and it includes telescope structure, main servos, primary mirror segment control system, wind, optics, wavefront sensor, deformable mirror, and an AO reconstructor and controller. There are t

Quality Control Analysis in Real-time (QC-ART): A Tool for Real-time Quality Control Assessment of Mass Spectrometry-based Proteomics Data*□S Bryan A. Stanfill‡, Ernesto S. Nakayasu§, Lisa M. Bramer‡, Allison M. Thompson¶, Charles K. Ansong§, Therese R. Clauss§, Marina A. Gritsenko§, Matthew E. Monroe§, Ronald J. Moore§, Daniel J. Orton§, Paul D. Piehowski§, Athena A. Schepmoes§, Richard D. Smith§

https://www.teddy.lu.se/sites/teddy.lu.se/files/2021-11/89%2009102019_679_089_MP172_Stanfill_Mol%20Cell%20Proteomics_2018.pdf - 2026-05-17

This essay explores the possible influence from WTO law into Community law in the area of State aid. In order to do so one needs to examine questions relating to material law as well as EC enforcement and procedure. Special attention is paid to State aid as regulated in Article 87.1 ECT. When an EC Member State thinks that another Member State is violating Article 87 ECT by administering illegal a

Uppsatsens syfte är att undersöka vilka straffrättsideologiska överväganden som kommer till uttryck i påföljdsbestämningens struktur. Av detta följer att de olika påföljdernas ideologiska grund kommer att beröras, samt frågan om vilka kriterier som är viktiga vid påföljdsvalet och straffmätningen och den än mer centrala frågan: varför är just dessa kriterier av betydelse? För att uppnå detta ändam

Due to the possibility of increased efficiency and reduced emissions, Homogeneous Charge Compression Ignition (HCCI) is a promising alternative to conventional internal combustion engines. Ignition timing in HCCI is highly sensitive to operating conditions and lacks direct actuation, making it a challenging subject for closed-loop control. This paper presents physics-based, control-oriented modeli

This paper describes preliminary results from the test-retest of the NAME 1.0. Four scales were tested: Mobility-related participation frequency; Mobility ease/difficulty; Mobility dependence; Extent of assistance in mobility. The test was conducted in the five Nordic countries. In all 147 mobility device users took part in the study, mean age 60 years (range 19 - 93). Each participant was intervi

The transcription factor interferon regulatory factor-8 (IRF8) is highly expressed in myeloid progenitors, while most myeloid leukemias show low or absent expression. Loss of IRF8 in mice leads to a myeloproliferative disorder, indicating a tumor-suppressive role of IRF8. The Wilms tumor gene 1 (WT1) protein represses the IRF8-promoter. The zinc finger protein ZNF224 can act as a transcriptional c

We address the problem of optimizing resource allocation for Perceptually based Unequal Packet Protection (PUPP) in a packet based voice carrying network. For that purpose, we design a novel real-time working Perceptually Based Classifier (PBC) optimizing the assignment of voice packets to either a Premium (Pch) or an Ordinary (Och) transmission Channel with regard to packet perceptual importance.

Background: The adoption of air conditioning (AC) is growing rapidly in developing countries across the world which puts a high burden on electricity distribution systems. This development is mostly driven by income growth and building design, but also due to increasing outdoor temperatures and to provide indoor thermal comfort. Current indoor thermal comfort standards are based on western clothin

Background: Delayed cerebral ischemia (DCI), a complication of subarachnoid hemorrhage (SAH), is linked to cerebral vasospasm and associated with poor long-term outcome. We implemented a structured cerebral microdialysis (CMD) based protocol using the lactate/pyruvate ratio (LPR) as an indicator of the cerebral energy metabolic status in the neurocritical care decision making, using an LPR ≥ 30 as

Background: Neuropsychiatric symptoms (NPS) are highly prevalent in Alzheimer's disease (AD) and are associated with negative outcomes. However, NPS are currently underrecognized at the memory clinic and non-pharmacological interventions are scarcely implemented. Objective: To evaluate the effectiveness of the Describe, Investigate, Create, Evaluate (DICE) method™ to improve the care for NPS in AD

We report a simplified, integrated and more efficient way of preparing DNA for analysis. We have developed a microfluidic platform that can purify DNA and subsequently label and stretch it on a surface. We have successfully extracted DNA from a gel-filled microfluidic channel using electrophoresis and subsequently stretched the DNA linearly by absorption to either a hydrophobic or a positively-cha

Major depressive disorder (MDD) has been linked to mitochondrial defects, which could manifest in mitochondrial DNA (mtDNA) polymorphisms or mutations. Additionally, copy number of mtDNA (mtDNA-cn) can be quantified in peripheral blood mononuclear cells (PBMC)s, indirectly reflecting cellular energetics, or in the circulating cell-free mtDNA (ccf-mtDNA) levels, which may reflect a fraction of the

In microbiology, cell analysis is an important tool for understanding influences on biotechnological production. Using current bulk methods, the secretome cannot be assigned to the corresponding cell. This contribution reports a novel method for cell separation inside microscale droplets. Cells are focused in droplets using bulk acoustic waves before the droplet is split at a bifurcation. For a wi

Objective: To determine if prior exposure to certain drugs is associated with increased risk of ANCA associated vasculitis(AAV).Patients and Method: We performed a population-based case–control study including patients with AAV diagnosed between2006 and 2019 from a defined geographic area in southern Sweden. For each case, we identified 10 controls randomly sampledfrom the background general popul

Structural Health Monitoring (SHM) plays a vital role in maintaining the integrity of structures by providing continuous information about damage or anomalies. Vibration-based SHM, which focuses on the dynamic behavior of structures, offers insights into structural conditions through changes in dynamic properties. Among SHM approaches, damage localization is crucial for pinpointing the geometric l

Objective: Inflammation is associated with major depressive disorder (MDD) and suicidal behavior. According to the ‘leaky gut hypothesis’, increased intestinal permeability may contribute to this relationship via bacterial translocation across enterocytes. We measured plasma levels of gut permeability markers, in patients with a recent suicide attempt (rSA), MDD subjects with no history of a suici

The pathogenesis of Parkinson’s disease (PD) involves the accumulation of aggregated -synuclein, which has been suggested to begin in the gastrointestinal tract. Here, we determined the capacity of the appendix to modify PD risk and influence pathogenesis. In two independent epidemiological datasets, involving more than 1.6 million individuals and over 91 million person-years, we observed that rem