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Treatment of chronic osteomyelitis by radical debridement and filling of the dead space with antibiotic containing calcium sulphate/hydroxyapatite (CaS/HA) bone substitute has shown excellent long-term outcomes. However, in extensive infections, sessile bacteria may remain in bone cells or soft tissues protected by biofilm leading to recurrences. The primary aim of this study was to evaluate if sy
Universities are increasingly being seen as a positive vehicle for territorial development and regional transformation, with an important role in enhancing Social, Economic and Sustainable Development of territories. The world’s sustainability challenges are listed in the United Nation’s Agenda 2030, that includes Higher Education Institutions (HEIs) as actors that can work in partnership with oth
The advent and popularity of shared electric scooters in many urban areas worldwide offer new opportunities and challenges to be addressed by the research community, especially as far as safety and accessibility issues are concerned. This paper proposes a methodology, based on geofencing technology (i.e., virtual geographic boundaries) to define in which urban areas the speed of shared electric sc
Background. We investigated how varying the treatment margin and applying hippocampal sparing and proton therapy impact the risk of neurocognitive impairment in pediatric medulloblastoma patients compared with current standard 3D conformal radiotherapy. Methods. We included 17 pediatric medulloblastoma patients to represent the variability in tumor location relative to the hippocampal region. Trea
This study investigated the dosimetric impact of uncompensated motion and motion compensation with dynamic multileaf collimator (DMLC) tracking for prostate intensity modulated arc therapy. Two treatment approaches were investigated; a conventional approach with a uniform radiation dose to the target volume and an intraprostatic lesion (IPL) boosted approach with an increased dose to a subvolume o
Responsible internationalization has become an increasingly used term to promote relationship building in a world which is increasingly shaped by the growing impact of global challenges and geopolitical competition. Amidst these changing global conditions researchers and universities have started to learn that they need to adhere to an expanded set of norms related to the research endeavor. Today
Globally, 500 million smallholder farmers require finance to secure a more productive, efficient, sustainable, and inclusive food system. Thus far, traditional financial services have been unsuccessful in reaching these farmers. Yet, mobile money services are proposed as a potential tool for enabling smallholder farmers access to financial services. Nonetheless, this proposed impact of mobile mone
Supply chain management (SCM) has become more challenging than ever, considering the effect of globalization on organizations as operating through transnational business networks. Conventional supply chains have been facing struggles such as lack of advanced technologies and traceability in operation, which then leads to operational inefficiencies. Blockchain (BC) technology offers a set of featur
The vehicle industry is making great strides in electric and hybrid technologies, representing a significant step towards reducing emissions from personal vehicles. In order to make the transition to new hybrid technologies as convincing as possible, well-functioning and smooth transitions between traditional combustion engines and electric motors are required. So-called mild hybrids enable a cos
The world continues to be shaped by crises in both new and familiar forms. International and non-international armed conflicts and disasters are barriers to individual wellbeing, development, stability, and in the case of the former, represent a basic challenge to peace. The aftermath of such crises, in which communities can be rebuilt and the fabric of society can be mended, can be a time for rec
Poly-3-D-hydroxybutyrate (PHB) is a biopolymer naturally produced by a range of bacterial species. PHB production both from glucose and xylose has also been enabled by engineering the robust baker’s yeast Saccharomyces cerevisiae, however yields remain low. In the present study, additional modifications were carried out in S. cerevisiae strains already expressing functional enzymatic pathways for
G protein-coupled receptor 30 (GPR30) is a ubiquitously expressed receptor reported to bind and become activated by estrogen (17β-estradiol). However, the role of GPR30 as an estrogen receptor for rapid estrogenic signaling is not completely accepted, and controversies exist regarding the identity of the cognate ligand, signaling, and subcellular localization of the receptor. Expression of GPR30 i
In this thesis the heating area of a belt furnace for annealing metal powder has been modeled. The model was extended with PI-controllers for controlling the energy added to the model. It was simulated with differently tuned controllers to test tuning principles for finding suitable control parameters for the process. The most promising tuning principles was then written as a manual with the aim f
Since the introduction of Edison’s lightbulb over one-hundred years ago, humanity has struggled to keep up with electrification for all. With global attention now aimed at sustainable energy production, the struggle becomes more complex by not only obliging energy access, but access to clean energy. The concept of microgrids has been promising for filling in the demand, but not quickly enough to m
Neonicotinoid insecticides are agonists to nicotinic acetylcholine receptors (nAChRs) in the brains of insects. At sub-lethal doses these chemicals cause behavioral abnormalities in several bee species, reducing overall fitness. nAChRs expressed in the optic lobes of insects bind neonicotinoids, thus may be involved in these behavioral changes. Here we attempted without success to visualize the pr
Tolkning och kvantifiering av strålningseffekter pga. atmosfäriska partiklar är en signifikant del av IPCC’s modellering av hur tidigare klimat förändrats och hur förändringar i framtiden kommer se ut. I den här studien vill vi strukturera och analysera observationer av huvudsakligen svavelpartiklar positionerade i stratosfären från naturliga och möjligtvis mänskliga källor, med hänvisning till va
Ethiopia is the second most populated country on the continent of Africa, with a high density of young people. Its economy remains largely based on agriculture, however, in recent years, slow structural change can be seen. Concurrently, youth education has been on the rise. Due to this phenomenon, the educated youth are now trying to match their skills with current employment opportunities. As a c
In this work a strategy for numerical simulation of punching during concurrent pressing of stainless steel sheet metal has been investigated accounting for the stress triaxiality and Lode angle parameter. Modelling of the damage evolution of a sheet metal is a useful tool within the field of engineering and materials science, and can provide useful information regarding material capabilities in a
