Search results

STED Nanoscopy of Interfaces and Interactions between Nanostructure Arrays and Living Cells The specific arrangement of membrane lipids and proteins in a living cell at the interface to high-aspect ratio nanostructures (nanowires and nanostraws) is still unknown – as are the dynamic structural adaptations and molecular rearrangements of living cells in the vicinity of such nanostructures. Whether

STED Nanoscopy of Interfaces and Interactions between Nanostructure Arrays and Living Cells The specific arrangement of membrane lipids and proteins in a living cell at the interface to high-aspect ratio nanostructures (nanowires and nanostraws) is still unknown – as are the dynamic structural adaptations and molecular rearrangements of living cells in the vicinity of such nanostructures. Whether

Due to unique electronic and optical properties, semiconductor nanowires (NW) are widely used in various opto-electronic devices. Concerns have been raised about using NW since they share morphological similarities with nanofibers, such as carbon nanotubes and asbestos. However, the effects of NW exposure on humans remain unknown and there is a pressing need to assess any possible NW toxicity. Dur

Development of multiple colorectal cancers (CRCs), synchronously or metachronously, is associated with hereditary predisposition for cancer and accurate risk estimates of multiple tumour development are relevant to recommend rational surveillance programs. A cross-sectional study design was used to estimate the risks of synchronous CRC (SCRC) and metachronous CRC (MCRC) based on data from the Nati

Background: In the phase 3 TITAN study, the addition of apalutamide to androgen deprivation therapy (ADT) significantly improved the primary endpoints of overall survival and radiographic progression-free survival in patients with metastatic castration-sensitive prostate cancer. We aimed to assess health-related quality of life (HRQOL) in TITAN, including pain and fatigue. Methods: In this randomi

The self-assembly of small colloidal clusters, so-called colloidal molecules, into crystalline materials has proven extremely challenging, the outcome often being glassy, amorphous states where positions and orientations are locked. In this paper, a new type of colloidal molecule is therefore prepared, assembled from poly(N-isopropylacrylamide) (PNIPAM)-based microgels that due to their well docum

The incidence of treatment-related neuroendocrine prostate cancer (t-NEPC) is rising as more potent drugs targeting the androgen signaling axis are clinically implemented. Neuroendocrine transdifferentiation (NEtD), an putative initial step in t-NEPC development, is induced by androgen-deprivation therapy (ADT) or anti-androgens, and by activation of the β2-adrenergic receptor (ADRB2) in prostate

Hereditary cancer that has monogenic inheritance affects every tenth patient, on average, who is diagnosed with cancer, and it has been suggested, based on twin studies, that approximately 30% of all cancer patients have a genetic predisposition to developing cancer. In this article, the author posited that familial syndromes become more organ specific with increasing age at tumor presentation to

Large-scale genome-wide association studies (GWAS) have identified approximately 35 loci associated with epithelial ovarian cancer (EOC) risk. The majority of GWAS-identified disease susceptibility variants are located in noncoding regions, and causal genes underlying these associations remain largely unknown. Here, we performed a transcriptome-wide association study to search for novel genetic lo

Purpose: Carriers of CDKN2A mutations have high risks of melanoma and certain other cancers. In this study we examined the occurrence of tumors among CDKN2A wild type (wt) members of melanoma-prone families with CDKN2A mutations. Methods: Swedish and US melanoma-prone families with CDKN2A mutations were included. Data was collected on tumors diagnosed among family members. Among the CDKN2A mutated

Brevmall Konstnär l iga fakulteten i Malmö Disputation och examen inom forskarutbildning Intern arbetsordning vid Konstnärliga fakulteten, Lunds universitet. Generellt gäller att institutionen ansvarar för praktiska frågor och fakultetskansliet ansvarar för formella beslut och övergripande samordning samt som stöd i processen. För detaljer se appendix samt i förekommande fall detaljerad info för r

https://www.konstnarliga.lu.se/sites/konstnarliga.lu.se/files/disputation_och_examen_vid_konstnarliga_fakulteten.pdf - 2026-05-30

Background: Low-cost particulate matter sensors have enabled new opportunities for exposure monitoring but require evaluation before application in epidemiological studies. This study assessed the performance of the SPS30 sensor integrated into the ARMIE portable monitoring sensor-node under controlled laboratory conditions. Methods: Sensors were co-located with two comparison instruments—the opti

Traffic-related air pollution has severe implications for our health and stringent emission legislation is being enforced to traffic emissions, for example in the EU, USA, and China. With stricter emission legislation (next is EURO 7) and a rapid growth of battery electrical vehicles (BEVs) the combustion-derived pollutants emitted from the tailpipe are decreasing. However, heavier vehicles have r