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BACKGROUND:: There is a large interindividual variability in thiopurine metabolism. High concentrations of methylthioinosine-5'-monophosphate (meTIMP) and low concentrations of 6-thioguanine nucleotides (6-TGNs) have been associated with a lower response rate and an increased risk of adverse events. In this study, the role of inosine-5'-monophosphate dehydrogenase (IMPDH) for differences in metabo

Background: Decades of progress in care and treatment for congenital heart disease (CHD) has gradually shifted the research focus from initial survival to long-term prognosis and the ageing of adults with CHD. Knowledge about the ageing adult with CHD will guide interventions to safeguard the quality of life across the life course. The present study compares the prevalence of frailty and cognitive

Background: Management of severe aortic stenosis (AS) has evolved over the past decade, driven by the widespread adoption of transcatheter aortic valve implantation (TAVI). This study aims to assess trends in procedural volumes, patient characteristics, and outcomes for patients undergoing TAVI or surgical aortic valve replacement (SAVR) in Sweden. Methods: This was a descriptive, non-comparative,

Fotboll och juridik är två system som under en längre tid setts som distinkt separata från varandra. Likväl, i takt med att den europeiska fotbollsindustrin fortsätter att växa gör också behovet av förutsägbar och hållbar lagstiftning det. Under de senaste trettio åren har Europeiska unionens domstol (EU-domstolen) kontinuerligt definierat idrottens särart som en undantagsprincip för sportindustriFootball and law are two systems that for a long time has been seen as distinctively separate from each other. However, as the European footballing industry continues to grow, so does the need for predictable and sustainable legislation. Throughout the last thirty years the Court of Justice of the European Union (CJEU) has been continuously defining the specificity of sport as a principle of exemp

Introduction: Most centers treating patients with anorectal malformation (ARM) will screen for anomalies of the kidneys and urinary tract by using ultrasonography. There is no consensus on whether screening for vesico-ureteral reflux (VUR) should occur. To meet the diagnostic needs of ARM patients a method was developed to include a simultaneous VUR diagnosis and pre-reconstructive fistula work-up

To meet national and international emission targets, the Swedish building sector needs to drastically reduce its carbon dioxide emissions, and to do so, a change in building techniques and materials is needed. Bio-based materials contribute to less emissions than conventional materials, like steel and concrete, but remain rather unknown to modern building sciences. This study aimed to increase kno

Kalkyl Dnr: Kalkylmall Uppdragsutbildning Total ersättning exkl omkostnader Institution: Fakultet: Indirekta kostnader % Indirekta 1 Inst 1 50% 41,979 86,936 Exkl moms Inkl moms 2 Inst 2 25% 7,601 20,504 Pris per deltagare ERROR:#DIV/0! ERROR:#DIV/0! 3 Inst 3 0% 0 0 Pris per hp/deltagare ERROR:#DIV/0! ERROR:#DIV/0! 4 Inst 4 0% 0 0 Pris per hp ERROR:#DIV/0! ERROR:#DIV/0! 5 LUCE Gem Förv 35% 32,358

https://www.staff.lu.se/sites/staff.lu.se/files/2024-01/Mall%20f%C3%B6r%20kostnadskalkyl%20uppdragsutbildning%20240119.xlsx - 2026-05-29

Aim: To compare the adherence to gluten-free diet between children with serology-based and biopsy-proven coeliac disease. Methods: Medical records were retrospectively reviewed in 257 Swedish children diagnosed with coeliac disease between 2012 and 2019 at a tertiary hospital. Adherence to a gluten-free diet was systematically assessed by trained dietitians at follow-up. Mixed models were used to

A series of quinone-based compounds were tested for their ability to act as external electron acceptors in the 1-dehydrogenation of-αmethyl-hydrocortisone-21-acetate, with polyurethane-entrapped Arthrobacter simplex cells in buffer-saturated n-decan-1-ol. This organic solvent was needed to solubilize the steroid substrate. In aqueous medium, the conversion with free cells virtually stopped after o

Previous research has focused on how governments and public authorities can limit civil society organisations’ (CSOs) autonomy by shrinking their operational civic space and their democratic functions. There has been less attention paid to how other external actors and types of pressure might restrict access to civic space and how it can induce coping responses on both an individual and organizati

We present a series of papers dedicated to modelling the accretion and differentiation of rocky planets that form by pebble accretion within the lifetime of the protoplanetary disc. In this first paper, we focus on how the accreted ice determines the distribution of iron between the mantle (oxidized FeO and FeO1.5) and the core (metallic Fe and FeS). We find that an initial primitive composition o

BACKGROUND: A prolonged QT interval plays a causal role in fatal arrhythmia and is known to be a risk factor for sudden cardiac death. Although diabetic patients with microvascular complications tend to have a longer QT interval, the therapeutic effect of diabetes on the QT interval remains unclear. Here, we assessed the changes in QT interval in patients with type 2 diabetes (T2D) who received mu

Objective: Extremes of prepregnancy maternal BMI increase neonatal mortality and morbidity at term. They also increase the risk of extremely preterm (EP, i.e., <27 weeks' gestational age) births. However, the association between maternal BMI and outcomes for EP babies is poorly understood. Methods: We used a cross-country design, bringing together the following three population-based, prospective,

Acute leukemia affects individuals of all ages and encompasses a heterogeneous group of malignancies driven by genetic alterations that give rise to leukemia stem cells (LSCs), which sustain self-renewal and drive the expansion of abnormal cells. Based on how these alterations affect maturation, acute leukemia is classified into acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).

Elisabeth Melander - SångHåkan Rydin - PianoLars Danielsson - BasTerje Sundby - Trummor & slagverkGöran Klinghagen - GitarrAnders Bergcrantz - TrumpetInge Petersson - Tenorsax"En av Sveriges stora jazzröster är tillbaka tillsammans med några av landets främsta musiker. En själfull röst, värme och känsla präglar mixen av egna kompositioner och spännande tolkningar av såväl Chick Corea, Miles Da

Background: The optimal treatment for metastatic high-grade gastroenteropancreatic (GEP) neuroendocrine neoplasms when Ki-67 ≤55% is unknown. A prospective multi-centre phase 2 study was performed to evaluate the efficacy and safety of everolimus and temozolomide as first-line treatment for these patients. Methods: Patients received everolimus 10 mg daily continuously and temozolomide 150 mg/m2 fo

Understanding the electronic structure and chemical bonding of transition metal complexes is important for improving the function of molecular photosensitizers and catalysts. We have utilized X-ray absorption spectroscopy (XAS) and resonant inelastic X-ray scattering (RIXS) at the Fe L3 edge to investigate the electronic structure of two Fe N-heterocyclic carbene complexes with similar chemical st

A search for the Higgs boson decaying into a pair of charm quarks is presented. The analysis uses proton–proton collisions to target the production of a Higgs boson in association with a leptonically decaying W or Z boson. The dataset delivered by the LHC at a centre-of-mass energy of [InlineEquation not available: see fulltext.] and recorded by the ATLAS detector corresponds to an integrated lumi

BACKGROUND/AIM: Diagnostic efficacy, defined as the percentage of rectal suction biopsy (RSB) specimens sufficient enough to determine the absence of ganglia cells in Hirschsprung's disease (HD) diagnosis, has been reported to be low, requiring repeated biopsies. The aim was to explore whether RSB diagnostic efficacy was influenced by the child's weight and to ascertain whether RSB efficacy differ