Filetype
Objective: The aim of this study was to analyze the impact of reproductive factors on breast cancer risk among Swedish women by using nationwide population registers. Methods: A cohort including all Swedish women born between 1920 and 1959 was followed up to 1997 by record linkage to different population-based registers. More than 4 million children were linked to the women in the cohort and 60,32
Objective. Recent work has shown that several soluble biomarkers, detectable in peripheral blood, synovial fluid, and/or urine, reflect remodeling of joint tissues and may therefore constitute outcome measures that reflect joint damage. Consequently, it is now desirable to begin the process of developing criteria for validation of a soluble biomarker as an outcome measure reflecting structural dam
BB-Diabetes Prone (BB-DP) rats, a model for endocrine autoimmune diseases, are severely lymphopenic, especially lacking ART2+ regulatory T cells. BB-Diabetes Resistant (DR) rats are not lymphopenic and do not develop autoimmunity. BB-DP and BB-DR rats only differ at the lymphopenia (lyp) gene (iddm2) on chromosome 4. Since BB-DP rats also show aberrancies in the differentiation of dendritic cells
Popular Abstract in Swedish Förekomsten av hudcancer ökar i ljushyade befolkningsgrupper och hudcancer tillhör de cancergrupper som ökar mest i Sverige. De tre vanligaste formerna av hudcancer är basalcellscancer, skivepitelcancer och malignt melanom. Under 2013 utgjorde skivepitelcancer och malignt melanom ca 16 % av alla cancerfall som rapporterades in till Svenska Cancerregistret; över 6 000 faSkin cancer incidence is increasing in fair-skinned populations. The three most common skin cancers are basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and malignant melanoma (MM). A correct diagnosis is crucial for an efficient and tailored treatment for the skin cancer patient. The purpose of this thesis was to evaluate different aspects of the preoperative diagnosis of skin cancer. Th
Background: Pre-hospital electrocardiogram (ECG) transmission to an expert for interpretation and triage reduces time to acute percutaneous coronary intervention (PCI) in patients with ST elevation Myocardial Infarction (STEMI). In order to detect all STEMI patients, the ECG should be transmitted in all cases of suspected acute cardiac ischemia. The aim of this study was to examine the ability of
A multi-proxy palaeoecological investigation including pollen, plant macrofossil, radiocarbon and sedimentological analyses, was performed on a small mountain lake in the Eastern Pyrenees. This has allowed the reconstruction of: ( 1) the vegetation history of the area based on five pollen diagrams and eight AMS(14)C dates and ( 2) the past lake-level changes, based on plant macrofossil, lithologic
Popular Abstract in Swedish Varför ser staden ut som den gör? Vilka krafter ligger bakom bebyggelsens och transportsystemets utformning? Vad eller vilka aktörer har inflytande över hur staden utformas? Hur kan internationella olikheter i städers utformning förklaras? De krafter som formar staden är många och komplexa. Stadens struktur har under historiens gång påverkats av bland annat nya teknologWhy do cities appear the way they do? What are the underlying forces that contribute to its built environment and transport system? What/whom are the factors/actors that influence the ways in which the city is shaped? How can the international differences in the shape of cities be explained? The driving forces that shape the city are numerous and complex. City structure, has through the ages, been
Objectives. To study possible nerve regeneration of a damaged auditory nerve by the use of stem cell transplantation. Methods. We transplanted HNPCs to the rat AN trunk by the internal auditory meatus (IAM). Furthermore, we studied if addition of BDNF affects survival and phenotypic differentiation of the grafted HNPCs. A bioactive nanofiber gel (PA gel), in selected groups mixed with BDNF, was ap
Friction-related problems are frequently encountered in control systems. This thesis treats three aspects of such problems: modeling, analysis, and friction compensation. A new dynamic friction model is presented and investigated. The model is described by a first order nonlinear differential equation with a reasonable number of parameters, yet it captures most of the experimentally observed frict
Ovariectomized virginal rabbits were treated with either estrogen or progesterone for 4 to 6 months. In vitro responses of muscle strips of the bladder and circular urethra were examined. Estrogen resulted in bladder contractions in response to noradrenaline and phenylephrine, whereas these agonists were without effect or evoked weak relaxations in castrated animals (and normals). Estrogen also ca
Large transformations of technologies have occurred in the Swedish economy during the last two centuries, resulting in higher income, better quality of products and changing composition of GDP. An agrarian society has given way to an industrial society and lately to a post-industrial phase. The energy supply systems have changed, from traditional energy carriers, such as firewood and muscle energy
BACKGROUND: Childhood pre-B acute lymphoblastic leukemia (ALL) is a bone marrow (BM) derived disease, which often disseminates out of the BM cavity, where malignant cells to a variable degree can be found circulating in the peripheral blood (PB). Normal pre-B cells are absolutely dependent on BM stroma for survival and differentiation. It is not known whether transformed pre-B ALL cells retain any
Popular Abstract in Swedish Denna avhandling är en dokumentation av mina undersökningar av det rumänska ordet. Jag har som allmänlingvist undersökt några aspekter av det rumänska ordet fonologiskt, fonetiskt och semantiskt. Det finns också mycket skrivet om morfologin i rumänska. Man är väl medveten om att en del suffix tar betoning och andra inte. Men ingen har utnyttjat denna kunskap för att sysThe book is divided into three parts. All three parts dealwith the Romanian word. Part A: Word stress has not been defined in one rule before. I show how one rule can be applied to nouns, verbs and countnouns of Romanian. The principal method is taken from lexical phonology. Part B: Part A gave me the idea to investigate phonological length in the forms of infinitive, 3sg imperfect and perfect. An
The spectrum and energy levels C IV and the 3l4l' system of the Mg-like ions in the iron group elements has been investigated. This has led to several hundred identified transitions, many of them previously unknown. Using the Charge Exchange diagnostic system at JET, ion temperatures, rotation velocities and densities have been derived from visible spectroscopic measurements on fully ionised light
Popular Abstract in Swedish Bakgrund En skada i en extremitet, som innebär att en perifer nervstam blir avskuren, medför ofta ett betydande handikapp med förlust av muskelkraft och känsel för patienten och därtill stora samhällskostnader, eftersom sådana skador i stor omfattning drabbar den arbetsföra delen av befolkningen. Det bästa behandlingsalternativet vid en sådan skada är att direkt sy ihoA new method, where a tendon segment – a tendon autograft – was used as graft material for peripheral nerve reconstruction, was developed. Defects, 10-15 mm long, in rat sciatic nerves were bridged by various modifications of tendons. A piece of an intact tendon and a tendon, that had been teased into a membrane and then rolled to form a loose “collagen roll”, supported axonal regeneration over a
Popular Abstract in Swedish POPULÄRVETENSKAPLIG SAMMANFATTNING PÅ SVENSKA Neuroblastom är en barntumör i nervsystemet som drabbar ungefär 14 barn i Sverige varje år. Neuroblastom uppstår under bildandet av det sympatiska nervsystemet, som är den del av nervsystemet som ansvarar för vår reaktion på fara och stress. Det sympatiska nervsystemet bildas under fosterutvecklingen och de första åren efteNeuroblastoma is a pediatric tumor derived from cells in the sympathetic nervous system. In an attempt to explain the heterogeneous clinical behavior of neuroblastoma tumors, neuroblastomas have been characterized with regard to their degree of sympathetic differentiation. Their expression of genes and proteins that regulate normal sympathetic development and cell cycle/cell death regulators was a
Popular Abstract in Swedish Målsättningen för detta arbete var att isolera caveolae för att kunna studera deras struktur och funktion. Caveolae är omegaformade inbuktningar i cellmembranet, ungefär 50-150 nm i diameter. Caveolae finns i många typer of celler, men inte i röda och vita blodkroppar eller nervceller. Man tror att de har flera viktiga funktioner. Exempelvis kan caveolae transportera moThe intention of this work was to establish alternative purification methods to obtain highly purified caveolae from various tissues. In order to isolate caveolae, sufficiently pure plasma membranes are needed. A method is presented for the isolation of plasma membranes from lung tissue using a combination of conventional polyethylene glycol/dextran two-phase partitioning and affinity partitioning
