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We present a structural analysis of halo star clusters in M31 based on deep Hubble Space Telescope (HST) Advanced Camera for Surveys (ACS) imaging. The clusters in our sample span a range in galactocentric projected distance from 13 to 100 kpc and thus reside in rather remote environments. Ten of the clusters are classical globulars, whilst four are from the Huxor et al. population of extended, ol
In this study, we investigate for the first time the efficiency of an environmentally sustainable extraction technique (pressurized liquid extraction, PIE) in conjunction with a fast separation technique (ultra-high performance liquid chromatography, UHPLC) coupled to a selective mass spectrometry (MS) detector (quadrupole time-of-flight, qTOF) to extract, separate and quantify fifteen intact-gluc
Because new modes of action for the treatment of psoriatic arthritis (PsA) are emerging, it is important to understand the use of switching to a second or third antitumor necrosis factor (anti-TNF) agent. This study investigated drug survival and treatment response rates of patients with PsA undergoing second- and third-line anti-TNF therapy.
Objective: We have previously shown the capacity of tenascin-C (TN-C) to induce inflammatory mediators and matrix degradation in vitro in human articular cartilage. The objective of the present study was to follow TN-C release into knee synovial fluid after acute joint injury or in joint disease, and to correlate TN-C levels with markers of cartilage matrix degradation and inflammation. Method: Hu
Global public-private partnerships for sustainable development have been framed as new instruments that can increase the democratic credentials and effectiveness of global governance. This article revisits 10 years of scholarship and practice of the 348 Johannesburg partnerships, adopted at the 2002 World Summit on Sustainable Development and reaffirmed at the UN Rio+20 summit in 2012. The article
BACKGROUND: Heart failure (HF) is a common complication to atrial fibrillation (AF), leading to rehospitalization and death. Early identification of patients with AF at risk for HF might improve outcomes. We aimed to derive a score to predict 1-year risk of new-onset HF after an emergency department (ED) visit with AF. METHODS AND RESULTS: The RE-LY AF (Randomized Evaluation of Long-Term Anticoagu
Through ultrarelativistic particle collisions at the LHC, it is possible to deconfine quarks and gluons. This deconfinement gives rise to a strongly interacting medium, referred to as the Quark-Gluon Plasma (QGP). One of the earliest proposed and observed signatures of the QGP was the enhanced production of strange hadrons since the medium can thermally produce strange quarks. However, recent stud
In previous years, the crisis communication literature has increasingly emphasised the need for closer examination of internal crisis communication, thereby focussing on employees during crises. Additionally, so far, no research has been conducted exploring internal crisis communication and its impact on employee well-being. The present study aimed at closing this gap by investigating whether inte
Even though language proficiency in children is strongly related to success in almost all domains, neurocognitive studies of L2 processing are typically limited to adults with several years of exposure, who may use general cognitive mechanisms to compensate for any difficulties in L2 processing. For example, whereas previous studies of adult bilinguals have reported differences in the anterior neg
The ICAO approach to risk management is essentially a technical model based on an engineering process viewpoint and is more applicable in concept to stable systems, such as chemical and nuclear industries. If airlines are to manage risk in a proactive manner they need to apply risk detection tools that provide real time and continuous systems oversight. This paper describes briefly the systems ap
We report the implantation of the Berlin Heart EXCOR (Berlin Heart, Berlin, Germany) as a pediatric biventricular assist device in a 10-month-old boy with primary graft failure after cardiac transplantation. The EXCOR was successfully used as a bridge to cardiac retransplantation. The pneumatically driven paracorporeal device supported the patient for 165 days until another suitable heart was obta
Aims: Patients with left axis deviation (LAD) and left bundle branch block (LBBB) show less benefit from cardiac resynchronization therapy (CRT) compared to other LBBB-patients. This study investigates the reasons for this. Methods: Sixty-eight patients eligible for CRT were included. Patients were divided into groups according to QRS-axis; normal axis (NA), left axis deviation (LAD) and right axi
Several yeast species, usually engineered by humans in order to produce compounds of biotechnological interests, are currently used as cellular factories. This thesis presents two main themes. In the first, Saccharomyces cerevisiae is used for bio-ethanol production from lignocellulose hydrolysates and in the second Pichia pastoris is used for the heterologous expression of human ameloblastin. Th
