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Streptococcus pyogenes is one of the most common bacteria infecting humans. One of the factors contributing to the disease-causing properties is the secreted streptococcal cysteine proteinase, SpeB, which degrades several host proteins in connective tissue and circulation. SpeB activity depends on the transformation from an inactive precursor, zymogen, into a mature proteinase. We show that
Background: Ocrelizumab is a humanized anti-CD20 antibody with increased antibody-dependent cellular cytotoxicity compared with rituximab. This phase I/II study evaluated its safety and efficacy in patients with relapsed/refractory follicular lymphoma (FL) after prior rituximab therapy. Design and methods: Forty-seven patients were treated in three dose cohorts and received eight infusions every 3
Streptococcus pyogenes (Group A streptococcus; GAS) is an important human pathogen responsible for mild to severe, life-threatening infections. GAS expresses a wide range of virulence factors, including the M family proteins. The M proteins allow the bacteria to evade parts of the human immune defenses by triggering the formation of a dense coat of plasma proteins surrounding the bacteria, includi
Primary hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder associated with autosomal recessive variants in genes required for perforin-mediated lymphocyte cytotoxicity. A rapid diagnosis is crucial for successful treatment. Although defective cytotoxic T lymphocyte (CTL) function causes pathogenesis, quantification of natural killer (NK)–cell exocytosis triggered by K562 targe
Recent epidemiological data on diseases caused by beta-hemolytic streptococci belonging to Lancefield group C and G ( GCS, GGS) underline that they are an emerging threat to human health. Among various virulence factors expressed by GCS and GGS isolates from human infections, M and M-like proteins are considered important because of their anti-phagocytic activity. In addition, protein G has been i
This study explores the use of manganese ore, iron-carbon particles (Fe-C), and gravel as anode fillers in electroactive constructed wetlands (ECWs) to treat wastewater containing pharmaceuticals and personal care products (PPCPs) including ciprofloxacin (CIP), ofloxacin (OFL), and naproxen (NPX), while also assessing bioelectricity production. Although the presence of PPCPs reduced pollutant remo
INTRODUCTION: Synaptic dysfunction and loss are pathological hallmarks of neurodegenerative diseases. Neuronal pentraxin 2 (NPTX2), a presynaptic protein involved in synaptic plasticity, has been linked to cognitive decline in Alzheimer's disease (AD) and other neurodegenerative disorders. METHODS: We developed and validated a novel single molecule array (Simoa) for NPTX2 in cerebrospinal fluid, w
Memories of the transition Memories of the transition is fictive. However, it is knowledge-based speculation. Much of the story is inspired by existing proposals, emerging innovations, or research on the transformations needed to meet our climate targets. We have collected some of these imaginative seeds below so that you can understand and construct your own vision of a post-fossil society. Conte
https://www.climatefutures.lu.se/ministryofimagination - 2026-05-23
Dansk Asylpolitik 1983-2011 - The Raoul Wallenberg Institute of Human Rights and Humanitarian Law Skip to content Search for: Search Button Home About Us Who We Are Our History About Raoul Wallenberg Our Theory of Change Staff Opportunities Annual Reports Whistleblower Our work What we do Multi-Disciplinary Research Higher Education Strategic Advice and Analysis Outreach Evaluation of Programme Wo
https://rwi.lu.se/publications/dansk-asylpolitik-1983-2011/ - 2026-05-22
Facial beat gestures align with pitch accents in speech, functioning as visual prominence markers. However, it is not yet well understood whether and how gestures and pitch accents might be combined to create different types of multimodal prominence, and how specifically visual prominence cues are used in spoken communication. In this study, we explore the use and possible interaction of eyebrow (Facial beat gestures align with pitch accents in speech, functioning as visual prominence markers. However, it is not yet well understood whether and how gestures and pitch accents might be combined to create different types of multimodal prominence, and how specifically visual prominence cues are used in spoken communication. In this study, we explore the use and possible interaction of eyebrow (
This presentation focuses the emotional dilemmas of social workers who recruit and assess foster parents, in a context increasingly defined by market dynamics. Following privatization paralleled with increasing need for childcare, private and public actors today compete to contract potential foster parents in Sweden. For this paper, 43 interviews (with social workers and managers), 21 observation
Meddelanden från HT-biblioteken | september 2025 Meddelanden från HT-biblioteken | september 2025 Publicerad den 15 september 2025 Foto: Alan Levine Här kommer höstens första nyhetsbrev. Vi presenterar höstens workshops för studenter och forskare. Som vanligt innehåller brevet också information om vårt nyförvärv, nu för alla sommarmånaderna, och om månadens e-resurs. Nytt och positivt är att två s
https://www.htbibl.lu.se/article/meddelanden-fraan-ht-biblioteken-september-2025/ - 2026-05-21
This thesis attempts to show tangible ways in which commodification of experience expands into areas outside of direct commercial activity, in contemporary mind and society. The user reviews of Google Maps (URGM) regarding places that don't offer sales of goods and services are being studied empirically, through qualitative text analysis. Functional analysis is also used to study the functions
The implementation of iris scan technology in the context of humanitarian financial assistance in UNHCR-run refugee camps raises an array of legal questions. While the collection and storage of biometrical data in other contexts is often accompanied by a critical discussion about data protection and privacy concerns, the use of such data in humanitarian settings is often left uncontested. The in-d
