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Background Cell and animal experiments have shown that beta-site APP-cleaving enzyme 1 (BACE1) may be involved in myelination. Objective Here, we assess the association of cerebrospinal fluid (CSF) BACE1 activity with multiple sclerosis (MS). Methods BACE1 activity and levels of secreted amyloid precursor protein (APP) and amyloid-beta (A beta) isoforms were analyzed in CSF from 100 patients with
The human DUSP15 gene encodes an uncharacterized 235-amino acid member of the subfamily of small dual specificity protein phosphatases related to the Vaccinia virus VH1 phosphatase. Similar to VHR-related MKPX (VHX) (DUSP22), the predicted protein has an N-terminal myristoylation recognition sequence, and we show here that both are indeed modified by the attachment of a myristate to Gly-2. In reco
Lipoprotein(a) [Lp(a)], a strong independent cardiovascular risk factor, consists of the unique apolipoprotein(a) [apo(a)] covalently linked to a low-density lipoprotein particle. Apo(a) contains a widely differing number of the plasminogen-like kringle IV, a size polymorphism that is codominantly inherited. In addition to powerful genetic control, renal failure is known to influence the plasma Lp
Systemic lupus erythematosus (SLE, OMIM 152700) is a complex autoimmune disease that affects 0.05% of the Western population, predominantly women(1-4). A number of susceptibility loci for SLE have been suggested in different populations, but the nature of the susceptibility genes and mutations is yet to be identified(5-9). We previously reported a susceptibility locus (SLEB2) for Nordic multi-case
European CH4 and N2O emissions are estimated for 2006 and 2007 using four independent inverse modelling systems, based on different global and regional Eulerian and Lagrangian transport models. This ensemble approach is designed to provide more realistic estimates of the overall uncertainties in the derived emissions, which is particularly important for verifying bottom-up emission inventories. We
We used two theoretical methods to estimate reduction potentials and acidity constants in Mn superoxide dismutase (MnSOD), namely combined quantum mechanical and molecular mechanics (QM/MM) thermodynamic cycle perturbation (QTCP) and the QM/MM-PBSA approach. In the latter, QM/MM energies are combined with continuum solvation energies calculated by solving the Poisson-Boltzmann equation (PB) or by
Utbildningspremier för kvinnor och män – utveckling under 2000-talet – utveckling under 2000-talet Utbildningspremier för kvinnor och män Utbildningspremier för kvinnor och män – utveckling under 2000-talet Thomas Ljunglöf, Håkan Regnér och Linda Simonsen © Saco 2023 www.saco.se http://www.saco.se/ Innehåll Innehåll 3 Sammanfattning 5 Inledning 7 Arbetskraftens utbildningsnivå 9 Data och metod 10
H I S T O R I S K A I N S T I T U T I O N E N | C E N T R U m f ö R g E N U S v E T E N S K A p Öresundsnätverket för genushistorisk forskning 13.15-13.30 Välkommen Jens Rydström 13.30-15.00 Tema: Kön och politik 13.30-14.30 Josefin Rönnbäck: Kvinnor, kvinnor, kvinnor. Utanför riksdagen, i parlamentet och i regeringen. I Sverige under det långa 1900-talet. 14.30-15.00 Anne Brædder: Femø kvindelejr
https://www.cors.lu.se/sites/cors.lu.se/files/2012nr2.pdf - 2026-06-07
LU-template English 16:9 Faculty of Science Lund university 1 A world-class university that works to understand, explain and improve our world and the human condition. Lund University vision 2 Faculty of Science 6 departments and one centre Around 1 000 employees Approx. 4000 students (1 800 full-time equivalents) Bachelor’s programme with 12 specialisations (3 in English) The hospital physics pro
https://www.science.lu.se/internal/sites/science.lu.se.internal/files/2026-03/faculty-of-science-2026_0.pptx - 2026-06-07
Great Spotted and Syrian Woodpeckers (Dendrocopos major and D. syriacus) are known to hybridize in nature; however, the extent of this phenomenon is not known due to difficulties in hybrid detection based on plumage analyses. Here, we tested five markers (one mitochondrial and four nuclear) and a set of six microsatellite loci for the identification of these two Woodpeckers and their hybrids. Sequ
Systolic tissue Doppler measurements (s') have been used to measure the velocity in myocardial motion and are a valuable tool for evaluating the systolic function of the left and right ventricles. Digestion of food is known to significantly alter hemodynamics and may therefore affect s'. The effect of food intake on s' parameters has not yet been studied. We assessed whether s' is affected by food
The transglucosylation reaction catalyzed by wild-type β-glucosidase CelB from hyperthermophilic Pyrococcus furiosus and active site mutants (M424K, F426Y, M424K/F426Y) was studied. The conversion of pentyl-β-glucoside to hexyl-β-glucoside in hexanol was used as a model transglucosylation reaction. Hydrolysis to glucose was a side reaction. The activity (rates of hydrolysis and transglucosylation)
Substrate properties can affect the thermal balance of organisms, and the colored integument, alongside other factors, may influence heat transfer via differential absorption and reflection. Dark coloration may lead to higher heat absorption and could be advantageous when substrates are cool (and vice versa for bright coloration), but these effects are rarely investigated. Here, we examined the ef
THE LITTLE STINT Calidris minuta is an Arctic wader species that migrates through the Baltic Sea region towards wintering areas in North and West Africa and the Mediterranean region. We use a 75-year trapping series, comprising 4,791 Little Stints on autumn migration, from Ottenby Bird Observatory in Sweden to illustrate long-term trends in abundance, phenology, and morphometrics. Numbers of trapp
The most complete and realistic physiological data are derived from direct measurements during human experiments; however, they present some limitations such as ethical concerns, time and cost burden. Thermophysiological models are able to predict human thermal response in a wide range of environmental conditions, but their use is limited due to lack of validation. The aim of this work was to vali
LUNARC was formed as a collaboration between groups in Theoretical Chemistry, Physical Chemistry 2, and Structural Mechanics in 1986. The founding members were later joined by Theoretical Physics and in 1996, LUNARC was transformed into a centre for scientific and technical computing at Lund University. Together with five other centres, LUNARC became a part of the Swedish National Infrastructure f
https://www.lunarc.lu.se/about/history - 2026-06-07
This essay deals with the question to which degree the notice of a general meeting of shareholders limits the meetings powers to make decisions. According to the Companies Act (hereinafter referred to as “ABL”) chapter 7 section 24 the notice must propose, in an agenda, the items which are meant to be dealt with at the general meeting. As a general rule the meeting does not have the power to make
In this study we compare different volatility models on their ability to forecast one day ahead volatility and value-at-risk (VaR). We compare five different GARCH specifications: GARCH, IGARCH, GJR-GARCH, EGARCH and APARCH, as well as EWMA, each paired with six different conditional distributions. These models are used to forecast volatility and VaR one day ahead using daily return data from the
