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Lysosomal membrane permeabilization (LMP) contributes to tissue involution, degenerative diseases, and cancer therapy. Its investigation has, however, been hindered by the lack of sensitive methods. Here, we characterize and validate the detection of galectin puncta at leaky lysosomes as a highly sensitive and easily manageable assay for LMP. LGALS1/galectin-1 and LGALS3/ galectin-3 are best suite
A series of poly(arylene piperidinium)s (PAPipQs) devoid of any alkali-sensitive aryl ether bonds or benzylic sites are prepared and studied as anion exchange membranes (AEMs) for alkaline fuel cells. First, the excellent alkaline stability of the model compound 4,4-diarylpiperidinium is confirmed. Medium molecular weight poly(arylene piperidine)s are then synthesized in polycondensations of N-met
INTRODUCTION: Merkel cell carcinoma is a rare malignant cutaneous neoplasm that is locally invasive and frequently metastasizes to lymph nodes, liver, lungs, bone and brain. The incidence of Merkel cell carcinoma has increased in the past three decades.CASE PRESENTATION: A 65-year-old Caucasian man presented with a sudden onset of severe headache and a three-month history of balance disturbance. M
For the last decades, molecular imprinting is developing intensively, especially in the case of the application of new imprinting techniques. In this work, for the first time, a Pickering emulsion polymerization was used to synthesize the S-naproxen-imprinted polymer spheres following a noncovalent protocol. To enhance the knowledge about imprinting process using mentioned technique, thorough anal
Rapidly developing viral resistance to licensed human immunodeficiency virus type 1 (HIV-1) protease inhibitors is an increasing problem in the treatment of HIV-infected individuals and AIDS patients. A rational design of more effective protease inhibitors and discovery of potential biological substrates for the HIV-1 protease require accurate models for protease cleavage specificity. In this stud
There are many projects in Mozambique for poverty reduction. One of these projects is funded by Millennium Challenge Account (MCA) and is aimed to install a total of 600 rural water points in the province of Nampula and Cabo Delgado in crystalline rock zone. Each water point consists of a drilled well, a water pump and a communal washing basin. Vertical Electrical Sounding (VES) was used for asse
Outcrops of the Ordovician System in South Africa are extensive; they cover significant portions of the Northern, Western and Eastern Cape provinces as part of the Cape Fold Belt as well as the KwaZulu-Natal Province as supracrustal cover overlying the Natal sector of the Paleoproterozoic Namaqua-Natal metamorphic province. Within the Cape Fold Belt, Ordovician rocks of the Table Mountain Group (P
When assessing the moisture damage risks of different external wall designs using hygrothermal simulation software, the user of said software can choose between different inputs for the determination of the indoor climate. This paper aims to compare results from field measurements in three Swedish buildings using different standards available in a widely used commercial hygrothermal simulation sof
Today, the advances in airborne LIDAR technology provide high-resolution datasets that allow specialists to detect archaeological features hidden under wooded areas more efficiently. Still, the complexity and large scale of these datasets require automated analysis. In this respect, artificial intelligence (AI)-based analysis has recently created an alternative approach for interpreting remote sen
Uppreningsprocessen av monoklonala antikroppar (mAbs) är dyr, speciellt det kromatografisteg där antikropparna separeras från andra protein och celler i lösningen från tidigare steg i processen. Antikropparna separeras från lösningen med hjälp av affinitetskromatografi, där det endast är antikropparna som interagerar med innehåller i kolonnen och stannar kvar, medan resten passerar obehindrat. AntThe purification process of monoclonal antibodies (mAbs) for therapeutic drugs is expensive, especially the chromatography step in which the mAbs are separated from other proteins and cells present in the feed. The antibodies are separated from the feed using affinity chromatography, where only the antibodies interact with active sites within the column, whereas the rest passes through the column
Limiting climate Impact of plastics “Solutions to limit the climate impact of plastics” was the topic of the 2018 Climathon in Lund. The 24 hour hackathon gathered 54 participants and was thereby one of the larger among the 113 Climathons held simultaneous all around the world. Climathon in Lund was organised by a consortia of five very different organisations, Lunds Universitet, Lunds Kommun, Sys
https://www.climate-kic.lu.se/climathon/climathon-lund-2018 - 2026-07-21
In the broad field of biology, our researchers study everything from small cells to large ecosystems. Research projects include the forces of evolution, unsung heroes of the soil, how animals navigate and seeking answers to the mystery of ageing. Animals with unique abilitiesHow do birds, insects and some other animal groups manage to keep a straight course over long distances? The fascinating abi
https://www.science.lu.se/research/our-research-areas/biology-life-our-planet - 2026-07-21
lum_2007_06 LUM Lunds universitets magasin | Nr 6 | 2007 doktorer i autofokus Så gick det efter byggfesten Tryggare karriärer för färre LUM nr 6 | 2006 hattparad LUM nr 6 | 2006 Det doftar krut. En morfar håller för öro- nen på sitt treåriga barnbarn som inte vill riskera att skrämmas av ännu ett kanon- skott från Wendes regemente. Så smäller det för 73:e och sista gången. Treåringen brister ut
https://www.lu.se/sites/www.lu.se/files/lunds-universitets-magasin-6-2007.pdf - 2026-07-21
Kursva¨rdering_GEOM09_2021 pa°skriven.png Course evaluation 2021: GEOM09 (summary based on the replies from seven students) 1. How did you perceive the course in general (from 1-5, where 1 is poor and 5 is excellent)? (1) (2) (3) (4) 43% (5) 57% 2. How did you perceive the level of the course (from 1-5, where 1 is too simple and 5 is too difficult)? (1) (2) 14% (3) 71% (4) 14% (5) 3. How easy was
https://www.geology.lu.se/sites/geology.lu.se/files/2021-09/GEOM09_Kursvardering_2021.pdf - 2026-07-21
Beskattning av pokervinster har inte minst under 2011 varit ett ämne för många diskussioner i media. Vissa anser att det krävs stora inslag av skicklighet för att vara duktig på poker och att det inte borde anses vara ett lotteri. Denna skicklighetsaspekt var fall för prövning i HD under 2011 i den s.k. Grebbestadsdomen. Vissa ansåg att domen skulle direkt avgöra om pokervinster skulle komma att bTaxation on poker winnings have not the least in 2011 been a topic of discussion in the media. Some believe that it requires significant element of skill to be good at poker and that it should not be considered a lottery. This skill aspect was tried in the Supreme Court in 2011 in the so-called Grebbestad verdict. Some felt that the appeal would directly determine whether poker profits would be ta
The effect of plant species diversity on productivity and competitive ability was studied in an experiment carried out simultaneously in five European countries: Czech Republic (CZ), the Netherlands (NL), Sweden (SE), Spain (SP), and United Kingdom (UK). The aim was to separate the 'chance' or 'sampling effect' (increasing the number of sown species increases the probability that a species able 't
1 Plant species differ in their capacity to influence soil organic matter, soil nutrient availability and the composition of soil microbial communities. Their influences on soil properties result in net positive or negative feedback effects, which influence plant performance and plant community composition. 2 For two grassland systems, one on a sandy soil in the Netherlands and one on a chalk soi
Methods have been studied for the production of chiral alcohols, which are of importance in organic synthesis of pharmaceuticals, agro-chemicals and fragrances, etc., through the enzymatic or microbial reduction of ketones. Classical reaction engineering was combined with genetic engineering to improve the production of chiral alcohols and kinetic resolution of racemic ketones with high enantiomer
REV_ISS_WEB_jnc_6650_113-4 836..847 *MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, UK Wallenberg Neuroscience Centre, Lund University, Lund, Sweden The midbrain dopaminergic (mDA) neurons are the largest assembly of dopaminergic neurons in the central nervous system and play an important role in motor control, reward, addiction and cognition (Bjorklund and Lindvall 1
