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The preservation of labile biomolecules presents a major challenge in chemistry, and deep eutectic solvents (DESs) have emerged as suitable environments for this purpose. However, how the hydration of DESs impacts the behavior of proteins is often neglected. Here, we demonstrate that the amino acid environment and secondary structure of two proteins (bovine serum albumin and lysozyme) and an antib
C4b-binding protein (C4BP) is a well-known regulator of the complement system that holds additional and important activities unrelated to complement inhibition. Recently, we have described a novel immunomodulatory activity in the minor C4BP(β-) isoform directly acting over inflammatory phagocytes. Here we show that incorporation of the β-chain to the C4BP α-chain oligomer interferes with this immu
There is a long history of avian studies investigating the impacts of urbanization. While differences in several life-history traits have been documented, either between urban and rural populations or across generalized urbanization gradients, a detailed understanding of which specific environmental variables cause these phenotypic differences is still lacking. Here, we quantified several local en
The respiratory pathogen Moraxella catarrhalis is a human-specific commensal that frequently causes acute otitis media in children and stimulates acute exacerbations in chronic obstructive pulmonary disease patients. The exact molecular mechanisms defining host-pathogen interactions promoting pathogenesis are not clearly understood. Limited knowledge hampers vaccine and immunotherapeutic developme
The non-uniform conditions and potential progression of fires in larger spaces calls for modelling methods extending outside of the traditional compartment fire framework. Even though a handful of studies in the area exist there is still little guidance available on how progressing fires in large enclosures can be modelled. Three different methods to calculate far-field gas temperature in large en
BACKGROUND: Efforts to establish the 2015 baseline and monitor early implementation of the UN Sustainable Development Goals (SDGs) highlight both great potential for and threats to improving health by 2030. To fully deliver on the SDG aim of "leaving no one behind", it is increasingly important to examine the health-related SDGs beyond national-level estimates. As part of the Global Burden of Dise
Livets minsta byggstenar är celler (från latinets cella; litet rum). Hos encelliga djur, t. ex bakterier och jäst innehåller de enskilda cellerna allt som behövs för att leva och föröka sig. Hos flercelliga organismer är cellerna specialiserade och bygger tillsammans med andra specialiserade celler upp vävnader, organ och hela organismer. Gemensamt för alla celler är att de utvändigt omsluts av etAquaporins (AQPs) are membrane-bound intrinsic water channels that allow the passive diffusion of water and small solutes across cellular membranes. There are 13 highly conserved isoforms of these channels in human, which differ in specificity, regulation and localisation in cells and tissues. The work in this thesis focuses on AQP0 and AQP2; water-specific aquaporins that are known to interact wi
PRELP is a member of the leucine-rich repeat family of extracellular matrix proteins in connective tissue. In contrast to other members of the family, the amino-terminal domain of PRELP has a high content of proline and positively charged amino acids. This domain has previously been shown to bind chondrocytes and to inhibit osteoclast differentiation. Here we show that PRELP mediates cell adhesion
All Swedish new-born infants were screened for alpha-1-antitrypsin (AAT) deficiency in 1972-74. The cohort of 127 PiZZ and 54 PiSZ individuals has been followed-up regularly.
Popular Abstract in Swedish I ett väderälskande land som Sverige finns det väl ingen som inte är bekant med den väderkarta som ger oss information om hur prognosen för den närmaste tiden ser ut? Många av oss tittar dagligen på väderrapporten och låter den hjälpa oss att bestämma om vi ska cykla eller ta bussen, sätta på grillen eller laga mat i ugnen. Genom enkla visualiseringar i form av sol, regWith the aid of modern computer technology the application of visualization and simulation technology has become increasingly important in today’s society. Through computer modelling it is possible to experience, understand and explore environments, systems or objects in two or three dimensions and to see, hear and sometimes tangibly feel them. It may be environments or objects that do not yet exi
Professor Contact details Email: erik [dot] swietlicki [at] fysik [dot] lu [dot] se Mobile: +46 70 992 45 12Organisation Combustion Physics Service point: 14 WebpageErik Swietlickis profile in Lund University research portalOther affiliations Member of Strategic Research Area NanoLund: Centre for Nanoscience Profile area member Lund Laser Centre, LLC Profile area member LTH Profile Area: Nanoscien
https://www.cec.lu.se/erik-swietlicki - 2026-07-20
We build a model to predict from first principles the properties of major mergers. We predict these from the coalescence of peaks and saddle points in the vicinity of a given larger peak, as one increases the smoothing scale in the initial linear density field as a proxy for cosmic time. To refine our results, we also ensure, using a suite of ∼400 power-law Gaussian random fields smoothed at ∼30 d
Digital healthcare services and digital health information, here called eHealth services, have the potential to reach people with diverse needs as both a complement to and a substitution for traditional healthcare. The access to and use of digital health information and digital healthcare services that are accessible and usable for people with impairments is a complex phenomenon.This potential is
This chapter introduces the research presented in the volume. It starts by highlighting the importance of an individual-level perspective to understand how long-term economic and societal changes connected with industrialization and post-industrialization have affected individuals and families during the twentieth century and into the twenty-first century as these changes pertain to social class,
We use data from the 17th data release of the Apache Point Observatory Galactic Evolution Experiment (APOGEE 2) to contrast the chemical composition of the recently discovered Gaia Enceladus/Sausage system (GE/S) to those of 10 Milky Way (MW) dwarf satellite galaxies: LMC, SMC, Boötes I, Carina, Draco, Fornax, Sagittarius, Sculptor, Sextans, and Ursa Minor. Our main focus is on the distributions o
St. Birgitta of Sweden (d. 1373) is one of the most celebrated female visionaries and authors of the Middle Ages and a central figure in the history of late-medieval religion. An aristocratic widow, Birgitta left her native country in 1349 and settled in Rome, where she established herself as an outspoken critic of the Avignon Papacy and an advocate of spiritual and ecclesiastical reform. Birgitta
Globally we are facing a complex web of grand challenges that are impacting the lived environment, our development pathways, and wider quality of life. Urban environments serve as a key context around which these grand challenges are not only experienced while also providing multiple opportunities to reduce environmental impacts and resource consumption; improve health outcomes; eradicate poverty;
We present high spectral resolution observations of the hot Jupiter WASP-94 A b using the HARPS instrument on ESO’s 3.6-m telescope in La Silla, Chile. We probed for Na absorption in its atmosphere as well as constrained the previously reported misaligned retrograde orbit using the Rossiter–McLaughlin effect. Additionally, we undertook a combined atmospheric retrieval analysis with previously publ
