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Popular Abstract in Swedish Ett nytt och experimentellt sätt att bota eller lindra sjukdomssymptom är att, istället för att tillföra en medicin, rätta till felet på en genetisk nivå. Detta kan åstadkommas genom att överföra nya, fungerande gener, sk transgener, till celler som då börjar producera protein, som i sin tur kan ge upphov till en terapeutisk effekt. I hjärnan skulle denna typ av behandlThe use of genetically modifi ed neural stem and progenitor cells could possibly be a future strategy for repairing a brain suffering from neurodegeneration. However, so far it has proven diffi cult to maintain sufficient levels of a transferred gene in suitable cell types, after transplantation. In the present thesis I studied the silencing of transgenes induced upon differentiation of neural pro

Haemophilus influenzae type b (Hib) escapes the host immune system by recruitment of the complement regulator vitronectin that inhibits the formation of the membrane attack complex (MAC) by inhibiting C5b-C7 complex formation and C9 polymerization. We previously reported that Hib acquires vitronectin at the surface by using Haemophilus surface fibrils (Hsf). Here we studied in detail the interacti

Popular Abstract in Swedish Livet uppe på en pelare År 423 e.Kr. klättrade en man som närmade sig fyrtioårsåldern upp på en pelare, för att leva resten av sitt liv på dess topp; det skulle bli nästan fyrtio år till på knappt tjugo meters höjd. Han hette Symeon och skulle redan i sin samtid bli världsberömd för sin märkliga livsstil, som den första styliten, eller pelarhelgonet. I dagens krigsdrabThe fundamental question in this work concerns the ideal relation between asceticism and society in a 5th c. writing (C.E.), the Philotheos Historia (PH), written in elaborate Greek by the learned bishop of Cyrrhus, Theodoret. This collection of saints’ stories tells about the lives of a number of ascetics who lived in the Eastern part of the Roman Empire, many of them close to Antioch. As these n

Popular Abstract in Swedish Organiska syraanhydrider (OSA) är reaktiva kemikalier med låg molekylvikt som används industriellt vid produktion av olika plaster, främst så kallade polyestrar och epoxiplaster. Där används de bland annat för att tvärbinda polymerer, det vill säga molekyler bestående av långa kedjor där små enheter av samma struktur upprepas. Det har visat sig att personer som exponeraOrganic acid anhydrides (OAAs) are low molecular weight chemicals used in the industry for manufacturing of plastics such as epoxy resins. Exposure to these chemicals may lead to symptoms from the eyes and the respiratory tract in form of conjunctivitis, rhinitis and asthma. In many workers production of specific IgE antibodies are induced suggesting that a type-1 allergy mediated mechanism is inv

Popular Abstract in Swedish Som skydd mot infektioner och andra omgivningshot har högre organismer utvecklat olika försvarssystem, där det mest betydelsefulla brukar sammanfattas under begreppet immunsystem. I detta ingår olika typer av specialiserade celler med ursprung i kroppens blodbildande organ, benmärgen. Den av immunsystemets olika celltyper som är viktigast för att skydda mot bakterieinfeThe serine proteases cathepsin G, leukocyte elastase, proteinase 3, and the inactive protease homologue azurocidin, stored in the azurophil granules of neutrophils, belong to a hematopoietic serine protease superfamily with members in mature effector cells of bone marrow origin. Promonocytic U-937 cells were used for studying the biosynthesis of cathepsin G and leukocyte elastase by biosynthetic r

Binding properties of staphylococcal protein A (SpA) to different human immunoglobulins have been investigated. In this analysis, intact SpA as well as SpA-derived fragments containing one to five IgG-binding domains of different compositions, were used. The affinity binding constants of the different proteins to human polyclonal IgG, IgA, IgM and F(ab')2-fragments as well as their binding capacit

Using near-infrared femtosecond absorption spectroscopy, we have determined the S-1 energies of the carotenoids spheroidene and rhodopin glucoside in LH2 complexes of purple bacteria. The S-1 energies in the LH2 complexes yield values of 13400 +/- 100 cm(-1) for spheroidene and 12550 +/- 150 cm(-1) for rhodopin glucoside, which are very close to the S-1 energies obtained for both carotenoids in so

OBJECTIVES:To report the initial experience of an international group of investigators in identifying mutations in the BRCA1 breast and ovarian cancer susceptibility gene, to assess the spectrum of such mutations in samples from patients with different family histories of cancer, and to determine the frequency of recurrent mutations.DESIGN:Nine laboratories in North America and the United Kingdom

BACKGROUND: Assessments of age-specific mortality and life expectancy have been done by the UN Population Division, Department of Economics and Social Affairs (UNPOP), the United States Census Bureau, WHO, and as part of previous iterations of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD). Previous iterations of the GBD used population estimates from UNPOP, which were not d

Background: For locally advanced Siewert type II and III tumors we have performed total gastrectomy including resection of the distal 2/3 of the esophagus, through separate abdominal and right chest incisions (THX-ABD). The procedure involves wide lymphadenectomy in the abdomen/chest and a Roux-en-Y jejunostomy to the level of the azygos vein or above. The aim of the study was to investigate short

BACKGROUND: Comparable data on the global and country-specific burden of neurological disorders and their trends are crucial for health-care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study provides such information but does not routinely aggregate results that are of interest to clinicians specialising in neurological conditions. In this syst