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Because of the use of agricultural land for wine production and the frequent use of copper (Cu)-based fungicides, Cu concentration has been increasing in soils in many parts of the world. In vineyards with acid parent materials, low soil pH may also encourage Cu toxicity, but it is common to use lime in order to increase the soil pH and improve crop yields. Thus, vineyard soils may have large vari
With the publication of the IPCC Special Report on Carbon dioxide Capture and Storage (CCS), CCS has emerged as a focal issue in international climate diplomacy and energy collaboration. This paper has two goals. The first goal is to map CCS activities in and among various types of intergovernmental organisations; the second goal is to apply International Relations (IR) theories to explain the gro
The delta C-13(org) chemostratigraphy of the Hirnantian and lower Rhuddanian in the biostratigraphically well-controlled Rostanga-1 drillcore from west-central Scania is used for an improved integration of the Hirnantian Isotope Carbon Excursion (HICE) with the standard graptolite zonation. In this drillcore succession, the end of the HICE corresponds to the top of the range of Metabolograptus per
To conduct a survey across European cardiac centres to evaluate the methods used for cerebral protection during aortic surgery involving the aortic arch.
The key step in the reaction mechanism of multicopper oxidases (MCOs)-the cleavage of the O-O bond in O-2-has been investigated using combined quantum mechanical and molecular mechanical (QM/MM) methods. This process represents a reaction pathway from the peroxy intermediate after it accepts one electron from the nearby type-1 Cu site to the experimentally-observed native intermediate, which is th
Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone with extrapancreatic effects beyond glycemic control. Here we demonstrate unexpected effects of GIP signaling in the vasculature. GIP induces the expression of the pro-atherogenic cytokine osteopontin (OPN) in mouse arteries, via local release of endothelin-1 (ET-1) and activation of cAMP response element binding protein (CR
The amount of carbon (C) stored in soil is an important regulator for the global climate and soil fertility and is the balance between formation and decomposition of soil organic matter (SOM). Decomposition of SOM can be powerfully affected by labile carbon (C) supplements in, for example, the rhizosphere. A stimulation of SOM mineralisation induced by labile C additions is termed priming', and th
Primary headaches such as migraine are postulated to involve the activation of sensory trigeminal pain neurons that innervate intracranial blood vessels and the dura mater. It is suggested that local activation of these sensory nerves may involve dural mast cells as one factor in local inflammation, causing sensitization of meningeal nociceptors. Immunofluorescence was used to study the detailed d
Three cranidia of a conocoryphid trilobite are described from the lower Caesaraugustan Regional Stage (upper part of provisional Cambrian Stage 5 within Cambrian Series 3) in the Iberian Chains, Spain. The material is from the upper part of the Mansilla Formation and the base of the overlying Murero Formation. It closely resembles Bailiella tenuicincta (Linnarsson, 1879), which has previously been
The 40 in thick Untersberg section (Salzburg, Austria) of the Northern Calcareous Alps comprises the Palaeocene-Eocene transition and spans the upper part of calcareous nannoplankton zone NP9 and the lower part of zone NP10 (subzone NP10a). These zones are equivalent to planktonic foraminifera zone P5 and the lower part of zone P6 (sub-zone P6a). The succession was deposited in a lower bathyal slo
Chloroquine (CQ) and mefloquine (MQ) are no longer potent antimalarial drugs due to the emergence of resistant Plasmodium falciparum. Combination therapy has become the standard for many regimes in overcoming drug resistance. Roxithromycin (ROM), a known p-glycoprotein inhibitor, is reported to have antimalarial activity and it is hoped it will potentiate the effects of both CQ/MQ and reverse CQ/M
To investigate the differential short-term effects of selective estrogen receptor (ER) modulators (SERMs) on uterus, we treated adult ovariectomized rats with a novel SERM, ospemifene (Osp), two previously established SERMs (tamoxifen and raloxifene (Ral)) and estradiol. The expression of two estrogen-regulated early response genes c-fos and vascular endothelial growth factor (VEGF), and DNA synth
In the process of producing ethanol from lignocellulosic materials, compounds inhibitory to enzymatic hydrolysis and fermentation are generated during the pretreatment of the wood. In an industrial process, these compounds will accumulate due to the recirculation of process streams. The inhibitory effects of the accumulation of volatile and nonvolatile compounds released during stream pretreatment
The aim of the study was to optimize the criteria for the BRCA1 and BRCA2 gene testing and to improve oncogenetic counseling in the Stockholm region. Screening for inherited breast cancer genes is laborious and a majority of tested samples turn out to be negative. The frequencies of mutations in the BRCA1 and BRCA2 genes differ across populations. Between 1997 and 2000, 160 families with breast an
We compared the Q10 relationship for root-derived respiration (including respiration due to the root, external mycorrhizal mycelium and rhizosphere microorganisms) with that of mainly external ectomycorrhizal mycelium and that of bulk soil microorganisms without any roots present. This was studied in a microcosm consisting of an ectomycorrhizal Pinus muricata seedling growing in a sandy soil, and
Hormone-mediated maternal effects may be an important mechanism for adjusting offspring phenotype to particular requirements of the environment. We manipulated the levels of testosterone and androstenedione in the yolk of collared flycatcher Ficedula albicollis eggs to investigate the effects of pre-natal exposure to androgens on growth and immune function. Androgen treatment tended to reduce the
Today, sheet-metal-forming simulation is a powerful technique for predicting the formability of automotive parts. Compared with traditional methods such as the use of try-out tools, sheet-metal-forming simulation enables a significant increase in the number of tool designs that can be tested before hard tools are manufactured. Another advantage of sheet-metal-forming simulation is the possibility
A lithostratigraphic subdivision of the topmost Slite Beds on western Gotland is proposed, viz. the Fröjel Formation (9-11 m) including the Svarvare Mudstone Member (2-3 m) and the Gannarve Siltstone Member (7-8 m). The Fröjel Formation resulted from increased siliciclastic deposition within an intracratonic carbonate platform setting during the mid-Homerian (Wenlock, Silurian). The temporal and s
