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In the European Union the Annexes of its chemical legislation (REACH) were revised and now clarify the technical data requirements for nanomaterials (NMs). These new provisions, effective from January 1, 2020, introduce requirements for manufacturers, importers and downstream users regarding registration and safety assessment of NMs. This study aims to assess the availability and suitability of me
Background and purpose — Many countries implemented strict lockdown policies to control the COVID-19 pandemic during March 2020. The impacts of lockdown policies on joint surgeries are unknown. Therefore, we assessed the effects of COVID-19 pandemic lockdown restrictions on the number of emergency and elective hip joint surgeries, and explored whether these procedures are more/less affected by loc
Swedish measures to fight the spread of COVID-19 differ from the strategies used in other comparable countries. In contrast to the lockdown approach that has been applied in many European countries, the Swedish strategy has been based to a substantial extent on individuals taking responsibility under non-binding recommendations. This contribution explores the Swedish strategy from a constitutional
Den politiska ordningen i rymden har tidigare betraktats som en förlängning av den politiska ordningen på jorden. I den här avhandlingen hävdar jag istället att den framväxande politiska ordningen i rymden definierar internationella förhållanden på jorden. Nya insikter om den politiska dynamiken i rymden ger oss därför en bättre förståelse för den nuvarande världsordningen. Dessutom ger en fördjupPolitical order in outer space has so far been perceived as an extension of the terrestrial political order. In contrast, I argue that the political order emerging in outer space defines international relations on Earth. Therefore, with a refreshed understanding of the political dynamics of outer space, we will be better equipped to grasp the contemporary world order. Moreover, deeper knowledge ab
The tumor microenvironment plays an essential role in supporting glioma stemness and radioresistance. Following radiotherapy, recurrent gliomas form in an irradiated microenvironment. Here we report that astrocytes, when pre-irradiated, increase stemness and survival of cocultured glioma cells. Tumor-naïve brains increased reactive astrocytes in response to radiation, and mice subjected to radiati
The evolution of sex chromosomes, and patterns of sex-biased gene expression and dosage compensation, are poorly known among early winged insects such as odonates. We assembled and annotated the genome of Ischnura elegans (blue-tailed damselfly), which, like other odonates, has a male-hemigametic sex-determining system (X0 males, XX females). By identifying X-linked genes in I. elegans and their o
Discontinuous Galerkin (DG) methods offer a great potential for simulations of turbulent and wall bounded flows with complex geometries since these high-order schemes offer a great potential in handling eddies. Recently, space-time DG methods have become more popular. These discretizations result in implicit schemes of high order in both spatial and temporal directions. In particular, we consider
OBJECTIVE: We review the existing research on environmentally sustainable surgical practices to enable SAO to advocate for improved environmental sustainability in operating rooms across the country. SUMMARY OF BACKGROUND DATA: Climate change refers to the impact of greenhouse gases emitted as a byproduct of human activities, trapped within our atmosphere and resulting in hotter and more variable
Recently in Joule, Lombardi et al. developed an approach to formulating socially and politically favorable energy-system decarbonization strategies, pointing out the strong impacts of weather on the developed optimal solution. Considering climate resilience has timely importance to guarantee the climate change adaptation of energy infrastructure while improving its sustainability.
Climate modelling studies indicate that subarctic ecosystems are predicted to show some of the earliest responses to climate change. The predicted temperature and precipitation changes have implications for the carbon biogeochemical cycle with ancillary effects in permafrost soils, vegetation, and stream networks. Browning, a result of changes in dissolved organic carbon (DOC) export to river syst
As a result of the devastating health effects of the COVID-19 outbreak, the lockdown has been considered a safety measure in many countries. In Pakistan, the first case of COVID-19 was reported in February 2020. The purpose of this qualitative study was to investigate people’s risk perception and protective behavior during the lockdown. Twenty-two (22) participants from eight big cities across Pak
Cell-based models of the blood-brain barrier (BBB) are important for increasing the knowledge of BBB formation, degradation and brain exposure of drug substances. Human models are preferred over animal models because of interspecies differences in BBB structure and function. However, access to human primary BBB tissue is limited and has shown degeneration of BBB functions in vitro. Human induced p
We have obtained the X-ray crystal structure of the galectin-8 N-terminal domain (galectin-8N) with a previously reported quinoline–galactoside ligand at a resolution of 1.6 Å. Based on this X-ray structure, a collection of galactosides derivatised at O3 with triazole, benzimidazole, benzothiazole, and benzoxazole moieties were designed and synthesised. This led to the discovery of a 3-O-(N-methyl
The increase in wildfire occurrence and severity seen over the past decades in the boreal and Arctic biomes is expected to continue in the future in response to rapid climate change in this region. Recent studies documented positive trends in gross primary productivity (GPP) for Arctic boreal biomes driven by warming, but it is unclear how GPP trends are affected by wildfires. Here, we used satell
