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BACKGROUND: Treatment of diabetic foot ulcers includes a number of different regimes such as glycaemic control, re-vascularization, surgical, local wound treatment, offloading and other non-surgical treatments. Although considered the standard of care, the scientific evidence behind the various debridements used is scarce. This presentation will focus on debridement and V.A.C. Therapy, two treatme

Anaerobic bacteria dominate the human normal microbiota but strikingly little is known about these commensals. Finegoldia magna is a Gram-positive anaerobe found in the skin and at other non-sterile body surfaces, but it is also an opportunistic pathogen. This study describes a novel protein designated FAF (F. magnaAdhesion Factor) and expressed by more than ninety percent of F. magna isolates. Th

From a longitudinal prospective study, 160 women with spontaneous menopause and without steroid medication were followed during the transition from pre- to postmenopause. After 12 years 152 women were still participating in the study. Blood samples were drawn every 6 months until 1 year after the menopause and every 12 months thereafter. Measurements of bone mineral density (BMD) on the forearm we

We studied leukemic stem cells (LSCs) in a Smad4(-/-) mouse model of acute myelogenous leukemia (AML) induced either by the HOXA9 gene or by the fusion oncogene NUP98-HOXA9. While HOXA9-SMAD4 complexes accumulate in the cytoplasm of normal hematopoietic stem- and progenitor cells (HSPCs) transduced with these oncogenes, there is no cytoplasmic accumulation of HOXA9 in Smad4(-/-) HSPCs and as a con

OBJECTIVES:: Brain tumour has few established determinants. We assessed to which extent risk of brain tumour was related to metabolic syndrome factors in adults. METHODS:: In the Me-Can project, 580 000 individuals from Sweden, Austria, and Norway were followed for a median of 10 years after baseline measurement. Data on brain tumours were obtained from national cancer registries. The factors of m

Background/Objectives:To examine associations between food patterns, constructed with cluster analysis, and colorectal cancer incidence within the National Institutes of Health-AARP Diet and Health Study.Subjects/Methods:A prospective cohort, aged 50-71 years at baseline in 1995-1996, followed until the end of 2000. Food patterns were constructed, separately in men (n=293 576) and women (n=198 730

Here we present a method for high-precision drilling using an industrial robot with high-bandwidth force feedback, which is used for building up pressure to clamp up an end-effector to the work-piece surface prior to drilling. The focus is to eliminate the sliding movement (skating) of the end-effector during the clamp-up of the end-effector to the workpiece surface, an undesired effect that is du

Bone metastasis is a leading cause of morbidity and mortality in prostate cancer (PCa). While cancer stem-like cells have been implicated as a cell of origin for PCa metastases, the pathways which enable metastatic development at distal sites remain largely unknown. In this study, we illuminate pathways relevant to bone metastasis in this disease. We observed that cyclin A1 (CCNA1) protein express

In order to move towards advanced 1-D models for secondary settling a more thorough understanding of compression is necessary. The inability of the current modelling frameworks to capture the variability in the compression phenomenon indicates that there is still something missing in the expression describing compressive settling. This can potentially be attributed to phenomena such as variations

The change in the subcellular distribution of Ca2+/calmodulin-dependent protein kinase II was studied in the rat hippocampus following normothermic and hypothermic transient cerebral ischemia of 15 min duration. A decrease in immunostaining of Ca2+/calmodulin-dependent protein kinase II was observed at 1 h of reperfusion which persisted until cell death in the CA1 region. In the CA3 and dentate gy

Almost three out of four EU citizens live in urban areas. Knowledge on the city’s environmental structure and capabilities is needed as urbanization is expected to continue. In this study, eight indicators on urban ecosystems condition (ECIs) were quantified for 305 EU cities (>100.000 inhabitants). A composite indicator (CI), based on the ECIs, indicated differences between northern and southern

OBJECTIVE: This study was designed to determine whether a relationship exists between previous exposure to measles, mumps, and rubella (MMR) by natural infection or vaccination or by new immunization with MMR vaccine, and either the presence or levels of autoantibodies against thyroid cell and pancreatic beta-cell antigens. METHODS: Antibodies against MMR and autoantibodies against thyroglobulin,

Purpose: Epidemiologic evidence supports an association between high mammographic density and increased breast cancer risk yet etiologic mechanisms remain largely unknown. Mixed evidence exists as to whether circulating lipid levels influence mammographic density and breast cancer risk. Therefore, we examined these associations in the Nurses’ Health Study (NHS) and Nurses’ Health Study II (NHSII),

An uncommon non-monotonic behavior of the temperature dependence of adiabatic laminar burning velocity has been found in over-rich methane+air flames at equivalence ratio, ϕ = 1.4. To find out the universality and reasons of this turning point, methane, ethane and propane + air flames are studied both experimentally by the heat flux method and numerically using GRI-mech, USC-mech, UCSD-mech, FFCM

Growing trade deficit has been one of the major problems of the Turkish economy to date. This study aims to provide empirical insights to policy makers about whether real depreciation or devaluation of Turkish Lira is an effective way of improving the trade deficit. The data employed in this study is quarterly and covers the period of 1987:1 and 2013:3. Recently developed Bounds test to cointegrat

In the aftermath of Brexit, the clashing narratives and identities have once again flared up on Northern Ireland. When in doubt about the future, an exploration into the past might be of use in order to avoid a continued conflict. This study will thus aim to research the identities and narratives put forth by the republican and the unionist/loyalist sides during the conflict on Northern Ireland. T

Sometimes are words most familiar to us, the hardest ones to define. They seem self-explanatory. Political concepts are not just words that create ambivalence. They affect and shape people’s lives. This thesis engages with the present context of the European Union (EU) and investigates the meaning of Citizenship and Active citizenship. It poses the questions; what do we need citizenship for? The c

To investigate the association between metabolic risk factors (individually and in combination) and risk of gallbladder cancer (GBC).